DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est4 and alpha-Est9

DIOPT Version :9

Sequence 1:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_731165.2	Gene:	alpha-Est9 / 40897	FlyBaseID:	FBgn0015577	Length:	587	Species:	Drosophila melanogaster

Alignment Length:	575	Identity:	228/575 - (39%)
Similarity:	312/575 - (54%)	Gaps:	78/575 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VVQTTHGKVRGILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLSKCLQV 75
            ||.||:|.::|:..||:|.:.:::|:.||:|.||:|.||:|.|...:.|..:|.|:....|.||.
  Fly    33 VVSTTYGPIKGVKRKSIYGQSYFSFERIPFAKPPVGELRYKAPQPPEVWTEVRSCTSQGPKPLQK 97

  Fly    76 STLTKEVEGSEDCLYLNISVKTL-NGDPMPVMVYIHGGAFKGGDSSRRAWGPDYFMKENVVYISI 139
            ..:.:..:|||||||||:..|.| ...||||||:|:||.|:.|::||..:.|||.::|:||.|||
  Fly    98 HFVFEMTDGSEDCLYLNVYTKNLYPTKPMPVMVWIYGGGFQFGEASRECYSPDYLLREDVVVISI 162

  Fly   140 GHRLGPL------------------GFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPE 186
            .:|||||                  |||.|:||:|:|||||||||.:|||||::||.:.|.||..
  Fly   163 NYRLGPLGTNDDTWKKKHIFNISLPGFLCLDDPELDVPGNAGLKDQVLALRWVKANCSRFGGDSA 227

  Fly   187 RITIFGHSSGSMTVQLLLASPQSEGLFHRAILLAGFSMELNRL------PQME--YRLAKHLGYE 243
            .|||||.|:||.:|..::.:.|:.||||:||.::|     |.|      ||..  ||||...||.
  Fly   228 NITIFGDSAGSASVHYMMITEQTHGLFHKAICMSG-----NTLSPWAVTPQRNWPYRLAVQAGYA 287

  Fly   244 GDNVDSQVLEFLLKADPALIVSA--DFFTPLEKRQGHNMPFKPSIESYSTPNAVLLAEPIDLQRT 306
            |:|....|.|||..|..:.|:.|  :.....||::.....|.|.||.|.|.:.|:..:||::.||
  Fly   288 GENNTRDVWEFLKNAKGSEIIKANGELCIDEEKKERIGFSFGPVIEPYVTSHCVVPKKPIEMMRT 352

  Fly   307 TWSNRIPIILGANSGEGMSIFSFVKMNPSWLKEF-QCNPERVLPWTLRNRCDPGQRRQLGQAL-- 368
            .|||.||:|:|..|.||:.::|..|.||..|.|. .|  ..|:|..|....:....|:.|..|
  Fly   353 AWSNNIPLIIGGVSNEGLLLYSETKTNPKCLNELDDC--RFVVPIELNMDRESALCREYGDQLRQ 415

  Fly   369 ------------IHHFCEAHGHELTVDHTNGLVELFTHGFVHAMDRLIQSRLTYGQ-APTYLYRF 420
                        :|.:.:...||.               |...:.|.:.|||.|.: ||||||||
  Fly   416 CYYGDKTPSLDTLHEYLQMVSHEY---------------FWFPIYRTVLSRLQYARSAPTYLYRF 465

  Fly   421 DFDSPDFNFYRIRFMGKEQRGVGHVDELGYIFKLPATFKLDKSRPEFTAIRRLVAMFVQFAATSD 485
            ||||..||..||...||:.||..|.|:|.|:|......||.....|:..|.|||.::..|||..:
  Fly   466 DFDSKHFNHLRILSCGKKVRGTCHGDDLSYLFYNSLARKLKNHTREYKCIERLVGLWTHFAACGN 530

  Fly   486 PN-APLTKSLVDWKPV--TRFGKRMV--LNISEELKFIPQPEMPKL----KFFDR 531
            || .|..:.|  |:||  ....|..:  ||||:|||.|..|::.||    .||.|
  Fly   531 PNFDPEQEDL--WQPVDPAAVEKHQLKCLNISDELKVIDVPDLKKLMVWESFFRR 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	225/571 (39%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	67/132 (51%)
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	214/545 (39%)
alpha-Est9	NP_731165.2	Aes	<115..>237	CDD:223730	61/121 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467387
Domainoid	1	1.000	222	1.000	Domainoid score	I1478
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	226	1.000	Inparanoid score	I2231
Isobase	1	0.950	-	0	Normalized mean entropy	S4412
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	10	9.840