DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est4 and Est-Q

DIOPT Version :9

Sequence 1:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_649321.1	Gene:	Est-Q / 40381	FlyBaseID:	FBgn0037090	Length:	559	Species:	Drosophila melanogaster

Alignment Length:	541	Identity:	145/541 - (26%)
Similarity:	243/541 - (44%)	Gaps:	107/541 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DYNEDAPVVQTTHGKVRGILLKSLY----DEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRD 64
            |.:|.|.|....:.....:|....|    |..|..|.|||:|.||:..|||:.|....||.|..:
  Fly    35 DASETATVTVELYNGQGTVLGNYAYTAWTDRAFMQFRGIPFAEPPIEELRFRPPVARSPWTGTLN 99

  Fly    65 CSKPLSKCLQVSTLTKEVEGS--EDCLYLNISVKTLNGDPMPVMVYIHGGAFKGGDSSRRAWGPD 127
            ......:|..::.|..::..:  ||||.|::..|.|:.. .|||.||:||.|..|.|....  |:
  Fly   100 ALNFGQRCPVITNLDSQMSDAELEDCLTLSVYTKNLSAS-QPVMFYIYGGGFYNGSSEDHP--PN 161

  Fly   128 YFMKENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITIFG 192
            |.::::||.:...:|:|.||:||....  |:||||.:.|:::||.|::.:.::|.|||:::||||
  Fly   162 YLLEKDVVLVVPQYRVGALGWLSTYTE--ELPGNAPIADILMALDWVQMHISSFGGDPQKVTIFG 224

  Fly   193 HSSGSMTVQLLLASPQS-EGLFHRAILLAG---FSMELNRLPQME-YRLAKHLGYEGDNVDSQVL 252
            .|:|:.....||.||:: :.:|.|||:.:|   .|..:|:.|:.: .|:...||..|.....|::
  Fly   225 QSAGAGVASSLLLSPKTGDNMFKRAIVQSGSIFASWAINKDPKAQSRRICIQLGCSGCEQHDQLV 289

  Fly   253 EFLLKA---DPALIVSADFFTPLEKRQGHNMPFKPS--IESYSTPNAVLLAEPIDLQRTTWSNRI 312
            :.:.||   |.....:::.|:|:.......:|.:||  ::||                   ..:|
  Fly   290 KCIQKAKVIDILKATASESFSPIVGDLHGILPQQPSELVKSY-------------------RRQI 335

  Fly   313 PIILGANSGEGMSIFSFV-------------KMNPSWLKEFQ------CNPERVLPWTLRNRC-- 356
            ||:.|....:|    |||             .::...:::|.      .|....|...:.||.
  Fly   336 PILTGFTQHDG----SFVLASYYDALAAKVANVSSLSVRQFSQGINDLVNDTSGLTDNILNRLLF 396

  Fly   357 DPGQRRQLGQALIHHFCEAHGHELTVDHTNGLVELFTHGFVH------AMDRLIQSRLTYGQAPT 415
            .|       |||     .:|.|...|   :...:|.|:.|:.      |.....|.|.|    |.
  Fly   397 KP-------QAL-----NSHDHSAAV---SSYFDLTTNIFMKSPVITLATKMYTQQRST----PV 442

  Fly   416 YLYRFDFDSP------DFNFYRIRFMGKEQRGVGHVDELGYIFKLPATFKLDKSRPEFTAIRRLV 474
            |:|.|:::..      :|......|.|    ||.|.::..|:|   ||..|:....:.:  :::|
  Fly   443 YVYSFEYEGTYTRFGYEFGNSHYPFNG----GVHHSNDNIYLF---ATHPLEGQDTQMS--QKMV 498

  Fly   475 AMFVQFAATSDPN--APLTKS 493
            .::..||....|.  :||:.:
  Fly   499 DVWTSFAIEGVPRNLSPLSSA 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	144/538 (27%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	47/115 (41%)
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	143/537 (27%)
Est-Q	NP_649321.1	Aes	<137..>240	CDD:223730	42/107 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	9	8.970