DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est4 and Ces3a

DIOPT Version :9

Sequence 1:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_941074.1	Gene:	Ces3a / 382053	MGIID:	102773	Length:	571	Species:	Mus musculus

Alignment Length:	565	Identity:	166/565 - (29%)
Similarity:	242/565 - (42%)	Gaps:	133/565 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PVVQTTHGKVRG--ILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLSKC 72
            |.|.|..|:|||  :.:|.. |.....|.|||:|..|||.|||..|...:||.|:||.|.....|
Mouse    37 PEVDTPLGRVRGRQVGVKDT-DRMVNVFLGIPFAQAPLGPLRFSAPLPPQPWEGVRDASINPPMC 100

  Fly    73 LQ----VS----TLTKEVE---GSEDCLYLNISVKT--LNGDPMPVMVYIHGGAFKGGDSSRR-- 122
            ||    :|    ||.::::   .|||||.|||...|  ..||..||||:||||:...|.|:..
Mouse   101 LQDVERMSNSRFTLNEKMKIFPISEDCLTLNIYSPTEITAGDKRPVMVWIHGGSLLVGSSTSHDG 165

  Fly   123 ----AWGPDYFMKENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNG 183
                |:|       :||.:::.:|||..||||..|.  .:|||.|..||:.||||::.|.|.|.|
Mouse   166 SALAAYG-------DVVVVTVQYRLGIFGFLSTGDK--HMPGNRGFLDVVAALRWVQGNIAPFGG 221

  Fly   184 DPERITIFGHSSGSMTVQLLLASPQSEGLFHRAILLAGFSMELNRLPQMEYRLAKHLGYEGDNVD 248
            ||..:||||:|:|.:.|..||.||.|.|||||||..:|.                        |.
Mouse   222 DPNCVTIFGNSAGGIIVSSLLLSPMSAGLFHRAISQSGV------------------------VI 262

  Fly   249 SQVLEFLL---------------KADPALIVSADFFTPLEKRQGHNMPFKPSIE-SYSTPNAVLL 297
            |::||.|.               .|.||.:|..     |.:::|.::..|.::. ||:..::...
Mouse   263 SKILEDLNAWSEAQNFANSVACGSASPAELVQC-----LLQKEGKDLITKKNVNISYTVNDSFFP 322

  Fly   298 AEPIDLQRTTWSNRIPIILGANSGE-GMSIFSF---------------VKMNPSWLKEFQCNPER 346
            ..|..|........:|.:||..:.| |..:..|               ::.:...|...|..||
Mouse   323 QRPQKLLANKQFPTVPYLLGVTNHEFGWLLLKFWNILDKMEHLSQEDLLENSRPLLAHMQLPPE- 386

  Fly   347 VLPWTLRNRCDPGQRRQLGQALIHHFCEAHGHELTVDHTNGLVELFTHGFVHAMDRLIQSR-LTY 410
            ::|..:....|.|......:..:        .||..|.|  ||          :..||.|: |..
Mouse   387 IMPTVIDEYLDNGSDESATRYAL--------QELLGDIT--LV----------IPTLIFSKYLQD 431

  Fly   411 GQAPTYLYRFDFDSPDFNFYRIRFMGKEQRGVGHVDELGYIFKLPATFKLDKSR----PEFTAIR 471
            ...|.:||.|......|..::..::..:     |..|..::|..|  |..|:|.    ||.|...
Mouse   432 AGCPVFLYEFQHTPSSFAKFKPAWVKAD-----HSSENAFVFGGP--FLTDESSLLAFPEATEEE 489

  Fly   472 R-----LVAMFVQFAATSDPNAPLTKSLVDWKPVTRFGKRMVLNI 511
            :     ::|.:.|||.|.:||.   |.|..|..:.:..:.:.:.:
Mouse   490 KQLSLTMMAQWSQFARTGNPNG---KGLPPWPQLNQLEQYLEIGL 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	166/565 (29%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	57/120 (48%)
Ces3a	NP_941074.1	COesterase	36..547	CDD:278561	166/565 (29%)
		Aes	75..>245	CDD:223730	74/178 (42%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832511
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.740