Protein Alignment alpha-Est4 and Ces1b

DIOPT Version :10

• Sequence 1: NP_524266.1
• Gene: alpha-Est4 / 40906
• FlyBaseID: FBgn0015572
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_001074841.1
• Gene: Ces1b / 382044
• MGIID: 3779470
• Length: 567
• Species: Mus musculus
• Alignment Length: 556
• Identity: 154/556 - (27%)
• Similarity: 230/556 - (41%)
• Gaps: 120/556 - (21%)

  Fly     5 YNEDAPVVQTTHGKVRGILLKSL--YDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSK 67
            ::..:|||.||.||:.| ...||  ::.....|.|:|:|.||||:|||..|...:||..:::.:.
Mouse    19 HSPSSPVVDTTQGKILG-KYTSLEGFEHPVAVFLGVPFAKPPLGSLRFAPPEPAEPWSFVKNATS 82

  Fly    68 PLSKCLQ-----------VSTLTKEVEG--SEDCLYLNI--SVKTLNGDPMPVMVYIHGGAFKGG 117
            ....|.|           :||..:.:..  |||||||||  .........:||||:||||....|
Mouse    83 YPPMCSQDAVAVQLLSDMLSTKKESIPPLFSEDCLYLNIYSPADLTKSSLLPVMVWIHGGGLMTG 147

  Fly   118 DSSRRAWGPDYFMKENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFN 182
            .:|... |......||||.::|.:|||..|..|..|....  ||....|.:.||||::.|.|||.
Mouse   148 GASLYN-GLALSAHENVVVVTIQYRLGIWGLFSTGDEHSR--GNWAHLDQLAALRWVQDNIANFG 209

  Fly   183 GDPERITIFGHSSGSMTVQLLLASPQSEGLFHRAI-----LLAGFSMELN----RLPQMEYRLAK 238
            |:|:.:|:||.|:|.::|.:|:.||.::.||||||     :|....:.|:    .|.||   :|.
Mouse   210 GNPDSVTVFGSSAGGVSVSVLVLSPLAKNLFHRAISESSVVLENIVITLDLVACDLSQM---IAT 271

  Fly   239 HLGYEG-----------DNVDSQVLEFLLKADPALIVSADFFTPLEKRQGHNMPFKPSIESYSTP 292
            ..|...           ...::::||..:|.:...:..|      ...:..|......|:....|
Mouse   272 VSGCNDTSSTAMVQCLRQKTENELLEITVKLEVTKVGGA------ASAKKDNTSMSTVIDGVVLP 330

  Fly   293 NA--VLLAEP----------IDLQRTTWSNRIPIILGANSGEGMSIFSFVKMNPS----WLKEFQ 341
            .|  .:|||.          .:.|...|.  ||.:||....||       |||..    .|:.|.
Mouse   331 KAPEEILAEKSFSTVPYIVGFNKQEFGWI--IPTMLGDLLSEG-------KMNEETASLLLRRFH 386

  Fly   342 CN---PERVLPWT----LRNRCDPGQRRQLGQALIHHFCEAHGHELTVDHTNGLVELFTHGFVHA 399
            .:   .|.::|..    ||...||.::|.|                       |:::|:..|...
Mouse   387 SDLNISESLIPAVIEKYLRGTDDPAKKRDL-----------------------LLDMFSDVFFGI 428

  Fly   400 MDRLIQSRLTYGQAPTYLYRFDFDSPDFNFYRIRFMG-KEQRGV--GHVDELGYIFKLPATFKLD 461
            ...|:...|......||:|.|.        ||..|:. |..:.|  .|.||:..:|.:| ..|..
Mouse   429 PAVLLSRSLRDAGVSTYMYEFR--------YRPSFVSDKRPQTVEGDHGDEIFSVFGIP-LLKEG 484

  Fly   462 KSRPEFTAIRRLVAMFVQFAATSDPNAPLTKSLVDW 497
            .|..|....:.::..:..||...:||.   :.|..|
Mouse   485 TSEEETNLSKMVMKFWANFARNGNPNG---EGLPHW 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	alpha/beta hydrolases	8..529	CDD:473884	154/553 (28%)
Ces1b	NP_001074841.1	COesterase	22..547	CDD:395084	154/553 (28%)