DRSC/TRiP Functional Genomics Resources

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Protein Alignment alpha-Est4 and Aadacl4fm1

DIOPT Version :10

Sequence 1:NP_524266.1 Gene:alpha-Est4 / 40906 FlyBaseID:FBgn0015572 Length:541 Species:Drosophila melanogaster
Sequence 2:NP_941064.2 Gene:Aadacl4fm1 / 381572 MGIID:2685880 Length:407 Species:Mus musculus


Alignment Length:217 Identity:56/217 - (25%)
Similarity:82/217 - (37%) Gaps:54/217 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 VRGILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLK------------PWHGIRD----CSK 67
            |.|:.:..|.| .|...|     |||      ..||.:|            .|..|.:    ||.
Mouse    16 VLGVNVWVLID-HFLTID-----VPP------SIPHPVKFRILHFCFHLTTTWGHILEKMNICSM 68

  Fly    68 PLSKC-LQVSTLTKEVEG--SEDCLYLNISV-----KTLNGDPMPVMVYIH-GGAFKGGDSSRRA 123
            |...| ||.|..:||..|  .:|..:..|.|     |..:..|...:::.| |||..|...|...
Mouse    69 PQFFCFLQDSLSSKENHGVFVKDLRFGTIPVRLFRPKAASSKPRRGILFFHGGGAMIGSLDSHHN 133

  Fly   124 WGPDYFMKENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILA-LRWIRANAANFNGDPER 187
            .......:.:.|.:|:|:|..|.    .:.|.|       ..|.|.| :.::::..| :..||.|
Mouse   134 LCTFLARETDSVLVSVGYRKLPY----YHHPSL-------YHDCINASIHFLKSLKA-YGIDPSR 186

  Fly   188 ITIFGHSSGS----MTVQLLLA 205
            :.|.|.|.|.    :..|.||:
Mouse   187 VVICGESIGGAAAVVVTQTLLS 208

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-Est4NP_524266.1 alpha/beta hydrolases 8..529 CDD:473884 56/217 (26%)
Aadacl4fm1NP_941064.2 alpha/beta hydrolases 115..380 CDD:473884 27/106 (25%)
Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3 119..121 1/1 (100%)

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