Protein Alignment alpha-Est4 and AADACL2

DIOPT Version :10

• Sequence 1: NP_524266.1
• Gene: alpha-Est4 / 40906
• FlyBaseID: FBgn0015572
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_997248.2
• Gene: AADACL2 / 344752
• HGNCID: 24427
• Length: 401
• Species: Homo sapiens
• Alignment Length: 385
• Identity: 83/385 - (21%)
• Similarity: 136/385 - (35%)
• Gaps: 124/385 - (32%)

  Fly    64 DCSKPLSKCLQVSTLTKEVEGSEDCLYLNISVKTLNGDPMP---------VMVYIHGGAFKGGDS 119
            |.::|||.  :..|:|       |..:::|.|:..    :|         .::|.|||.|..|.|
Human    69 DYTQPLSD--EYITVT-------DTTFVDIPVRLY----LPKRKSETRRRAVIYFHGGGFCFGSS 120

  Fly   120 SRRAWGPDYFMK-----ENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAA 179
            .:||:  |:..:     .:.|.:.:.:||.|.........|    |.|.:|..:|     .....
Human   121 KQRAF--DFLNRWTANTLDAVVVGVDYRLAPQHHFPAQFED----GLAAVKFFLL-----EKILT 174

  Fly   180 NFNGDPERITIFGHSSGSMTVQLLLASPQSEG-LFHR----AILLAGFSMELNRLPQMEYRLAKH 239
            .:..||.||.|.|.|||......:....|::. :.|:    .:|..|..:..:.||  .:|..:|
Human   175 KYGVDPTRICIAGDSSGGNLATAVTQQVQNDAEIKHKIKMQVLLYPGLQITDSYLP--SHRENEH 237

  Fly   240 LGYEGDNVDSQVLEFLLKADPALIVSADFFT-----PLEKRQGHNMPFKPSIESYSTPN-AVLL- 297
                         ..:|..|.|:.:.:.:||     |...|:..:||.: |...:...| ::||
Human   238 -------------GIVLTRDVAIKLVSLYFTKDEALPWAMRRNQHMPLE-SRHLFKFVNWSILLP 288

  Fly   298 ---------AEPI------DLQRTTWSNRIPIILGANSGEGMSIFSFVKMNPSWLKEFQCNPERV 347
                     .|||      .|...|.|..:|::                .|.|.|:.
Human   289 EKYRKDYVYTEPILGGLSYSLPGLTDSRALPLL----------------ANDSQLQN-------- 329

  Fly   348 LPWTLRNRC------DPG-----QRRQLGQALIHHFCEAHGHELTVDHTNGLVELFTHGF 396
            ||.|....|      |.|     :.|.:|..::|...|        |..:|.:...|..|
Human   330 LPLTYILTCQHDLLRDDGLMYVTRLRNVGVQVVHEHIE--------DGIHGALSFMTSPF 381

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	alpha/beta hydrolases	8..529	CDD:473884	83/385 (22%)
AADACL2	NP_997248.2	Abhydrolase_3	107..372	CDD:400284	70/323 (22%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	111..113		1/1 (100%)