DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est4 and CG3841

DIOPT Version :9

Sequence 1:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_001188759.1	Gene:	CG3841 / 34278	FlyBaseID:	FBgn0032131	Length:	564	Species:	Drosophila melanogaster

Alignment Length:	532	Identity:	166/532 - (31%)
Similarity:	252/532 - (47%)	Gaps:	77/532 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DAPVVQTTHGKVRGILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPW-HGIRDCSKPLSK 71
            |.|||:.:.|:::|..::|..::..|||.||.||..|:|.|||..|.....| ..:.:.:.....
  Fly    27 DDPVVELSLGRIQGDTMQSFGNKTIYAFRGIRYAQSPVGQLRFANPVPETSWGDEVFNATSDSLV 91

  Fly    72 CLQ---VSTLTKEVEGSEDCLYLNISVKTLNGDPMPVMVYIHGGA--FKGGDSSRRAWGPDYFMK 131
            |.|   ||.:      |||||.:|:..|:.. |..||||||||||  ...|.||..| ||.|.:.
  Fly    92 CPQPGVVSLM------SEDCLKINVFTKSFE-DKFPVMVYIHGGANVLGSGHSSYEA-GPQYLLD 148

  Fly   132 ENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITIFGHSSG 196
            ::||:::..:|||.|||||.|..  |..||.|..|.::||.|:|.:.::|.||||.:||.|.|:|
  Fly   149 QDVVFVAFNYRLGALGFLSTNSS--ETKGNFGFLDQVMALEWVRDHISHFGGDPELVTIIGISAG 211

  Fly   197 SMTVQLLLASPQSEGLFHRAILLAGFSMELNRLPQMEY--RLAKHLG---YEGDNVDSQVLEFLL 256
            ||.|.|.||||.|.||||||||::|.:.....:..:.:  :||:.||   |:    .:.|:|.|.
  Fly   212 SMAVSLHLASPLSAGLFHRAILMSGSATNHFDIDNLFWTRKLARELGCPMYD----PTDVVECLR 272

  Fly   257 KADPALIVSADFFTPLEKRQGHNMPFKPSIESYSTPNAVLLAEPIDLQRTTWSNRIPIILGANSG 321
            ......||  :.....|..|..||.:...|:.:...|     .|.:|.:....|::|:::...:.
  Fly   273 NETWTRIV--EVCKAWETYQLVNMKWNYEIDGHFLHN-----HPTELIKEGNFNKVPLLISFTAN 330

  Fly   322 EGMSIFSF---VKM-NPSWLKEFQCNPERVLPWTLRNRCDPGQRRQLGQALIHHFCEAHGHELTV 382
            |    |.:   |.: |...|.:|..|.....|.....|.|    .|:|:.|...:...:..|:..
  Fly   331 E----FDYNANVHLENQHLLHDFASNFVDYAPELFLYRHD----AQIGEKLKDFYLGDNTTEINS 387

  Fly   383 DHTNGLVELFTHGFV-HAMDRLIQ--SRLTYGQAPTYLYRFDF------DSPDFNFYRIRFMGKE 438
            ::.....::|:..:: |.:.||:|  |..|    |.|..|.|:      .:|         :..|
  Fly   388 ENIENFGQIFSDAYIGHGVHRLVQLASHFT----PVYYTRMDYVGDQSLSAP---------LNGE 439

  Fly   439 QR--GVGHVDELGYIFKLPATF---KLDKSRPEFTAIRRLVAMFVQFAATSDPNAPLTKSLVDWK 498
            .:  ||||.|:|.|:  ||..:   .:..:..:...:.||.:.|..||.|..|    ..|...|.
  Fly   440 NKPVGVGHADDLHYV--LPGYWYGPLMAANDSDVFMMERLTSWFTHFAKTGTP----LNSTDIWP 498

  Fly   499 PVTRFGKRMVLN 510
            |......:|:.|
  Fly   499 PCNSTVLKMLYN 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	166/532 (31%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	63/116 (54%)
CG3841	NP_001188759.1	COesterase	27..528	CDD:278561	166/532 (31%)
CG3841	NP_001188759.1	Aes	<116..>235	CDD:223730	65/122 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467414
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	9	8.890