DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est4 and CG9287

DIOPT Version :9

Sequence 1:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_609244.1	Gene:	CG9287 / 34194	FlyBaseID:	FBgn0032057	Length:	625	Species:	Drosophila melanogaster

Alignment Length:	566	Identity:	152/566 - (26%)
Similarity:	233/566 - (41%)	Gaps:	126/566 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DYNEDAPVVQTTHGKVRGILLKSLYDE-QFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSK 67
            |..:|..|...|.|.::|.:|::.:.: :...|..:.||.||.|..|||.|..::||..:.|.:.
  Fly    29 DEEKDTIVELPTLGSIQGKILETAWTKREVLQFVDVRYAEPPTGLHRFKAPRPIEPWEDVMDATA 93

  Fly    68 PLSKCLQVSTLTK-----EVEGSEDCLYLNISVKTLNGDPMPVMVYIHGGAFKGGDSSRRAWGPD 127
            ....|..|.::..     :|...||||.:.|:...:. ..:||:|||||.....|.:|...  ||
  Fly    94 EKIGCPSVVSMDSLRRLDDVLDVEDCLTMTITTPNVT-SRLPVLVYIHGEYLYEGSNSEAP--PD 155

  Fly   128 YFMKENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITIFG 192
            |.::::||.::..:||||.||||....  |:|||||..|:.|||::::.....|.|||.|:|:.|
  Fly   156 YLLEKDVVLVTPQYRLGPFGFLSTKTD--EIPGNAGFLDIFLALQFVKHFIKYFGGDPSRVTVAG 218

  Fly   193 HSSGSMTVQLLLASP-QSEGLFHRAILLAGFSMELNRLP-QMEYRLAKHLGYEGDNVDSQVLEFL 255
            ...|:....||..|| ...||||:.|..:|.::    :| .:|....||           ..|..
  Fly   219 QVGGAAIAHLLTLSPVVQRGLFHQVIYHSGSAI----MPIFLEEDPRKH-----------AQEIA 268

  Fly   256 LKADPALIVSADFFT-----------------PLEKRQ---GHNMPFKPSIESYSTPNAVLLAEP 300
            .|||..::...|..|                 .|||..   ||....:.:|   ..|:.||...|
  Fly   269 KKADCKMVTVRDLNTCLMELTALELLTAFMEHALEKSDLGIGHTGGIQFTI---GGPSGVLPKHP 330

  Fly   301 IDLQ-RTTWSNRIPIILGANSGEGMSIFSFVKMNPSWLKEFQCNPERVLP---WTLRNRCDPGQR 361
            .||. .|.:|  .|.:.|.....|..:.:.:..|     :|    |..:|   :...|..|...|
  Fly   331 YDLMLETNFS--YPAMGGCPKNAGSRVLNEIVDN-----DF----EGKIPDDEYNTYNYIDHVIR 384

  Fly   362 RQLGQALIHHFCEAHGHELTVDHTNGLVELFTHGFV-------------------------HAMD 401
            :.:|                .|.|..|....||.|.                         |.:.
  Fly   385 QTVG----------------TDKTMLLTSFVTHDFFNRNLMENGTFDTLIPRLIDVAGTLNHKLP 433

  Fly   402 RLIQSRLTYGQAP--TYLYRFDFDSPDFNFYRIRFMGKE-------QRGVGHVDELGYIFKLPA- 456
            .|:...:.....|  |:||.||: :.:||  |.:.|.:|       :.||...||..|:|..|.
  Fly   434 VLLALNMNNKHNPDNTFLYSFDY-AGEFN--RYKEMDEETNLQSPFKAGVSLTDEALYLFPYPEH 495

  Fly   457 TFKLDKSRPEFTAIRRLVAMFVQFAATSDPNAPLTKSLVD-WKPVT 501
            ..:|  |||:.:...|:|.::..|..:.:   ||..:.|. |.|:|
  Fly   496 VTRL--SRPDQSMAHRMVELWTNFVISGN---PLGSARVGYWPPMT 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	151/563 (27%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	49/115 (43%)
CG9287	NP_609244.1	COesterase	31..558	CDD:278561	151/564 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467463
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.900