DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est4 and cel.1

DIOPT Version :9

Sequence 1:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_955901.2	Gene:	cel.1 / 322481	ZFINID:	ZDB-GENE-030131-1201	Length:	550	Species:	Danio rerio

Alignment Length:	542	Identity:	154/542 - (28%)
Similarity:	233/542 - (42%)	Gaps:	97/542 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 GKVRGILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLSKCLQVSTLTKE 81
            ||.|.:.|....|    .|.|||:|.||   .||::|.....|.|:...:....:|||::.|..:
Zfish    34 GKSRSVGLFRYMD----TFKGIPFAAPP---KRFEKPVAHPGWEGVLKTTDYRKRCLQLNLLATD 91

  Fly    82 VEGSEDCLYLNISV---KTLNGDPMPVMVYIHGGAFKGGDSSRRAWGPDYFM-------KENVVY 136
            |.||||||||||.|   :|::.: :||||:|:||||..|......:..:|..       :.||:.
Zfish    92 VIGSEDCLYLNIWVPQGRTVSSN-LPVMVFIYGGAFLLGGGQGANFLDNYLYDGEEMADRGNVIV 155

  Fly   137 ISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITIFGHSSGSMTVQ 201
            ::..:|:|.|||:|..|..  :|||.||.|...|:.|:..|...|.|:|:.||:||.|:|:.:|.
Zfish   156 VTFNYRVGALGFMSTGDDG--IPGNYGLWDQHAAISWVHRNIKAFGGNPDNITLFGESAGAASVN 218

  Fly   202 LLLASPQSEGLFHRAILLAGFSM---ELNRLP-QMEYRLAKHLGYEGDNVDSQVLEFLLKADPAL 262
            ..:.:|:::|:..|||..:|.::   .::|.| |....:|..:|..   :||.:.:.|.:|||..
Zfish   219 FQIITPKNKGMIRRAISQSGVALCPWAISRNPRQFAEEIATKVGCP---IDSGMADCLKRADPKA 280

  Fly   263 IVSADFF-------TPLEKRQGHNMPFKPSIESYSTPNAVLLAEPIDLQRTTWSNR--IPIILGA 318
            :..|...       .|:.    ||:...|.|:....|:     ||    .|.:.|.  |..|.|.
Zfish   281 VTLAGKLKLTSSPDAPIV----HNLYLSPVIDGDFIPD-----EP----ETLFGNAADIDYIAGV 332

  Fly   319 NSGEGMSIFSFVKMNPSWLKEFQCNP-ERVLPWTLRNRCDPGQRRQLGQALIHHFCEAHGH---- 378
            |..:. .||:.:.: ||........| |.|.........|.||  ..|.|....:....|.
Zfish   333 NDMDA-HIFATIDI-PSINNALTTTPVEEVQALATALSRDRGQ--DAGIATFQEYTVNWGDKPNK 393

  Fly   379 --------ELTVDH-----TNGLVELFTHGFVHAMDRLIQSRLTYGQAPTYLYRFDFDS--PDFN 428
                    ||..|:     |...:.|.|       |....:|       |:.|.|...|  |.|.
Zfish   394 EKVKQTVVELETDYMFLVPTQAALYLHT-------DNAKSAR-------TFSYLFTESSRIPVFP 444

  Fly   429 FYRIRFMGKEQRGVGHVDELGYIFKLPATFKLDKSRPEFTAIRRLVAMFVQFAATSDPNAPLTKS 493
            .:         .|..|.|||.|:|..|....|..........:.::|.:..||.|.|||...:|.
Zfish   445 LW---------MGADHADELQYVFGKPFATPLGYFPRHRDVSKYMIAYWSNFAQTGDPNKGESKV 500

  Fly   494 LVDWKPVTRFGKRMVLNISEEL 515
            .|.|...:..| ...|:|:.::
Zfish   501 PVTWPEFSNPG-HQYLDINNKM 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	154/542 (28%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	44/121 (36%)
cel.1	NP_955901.2	COesterase	25..517	CDD:306613	153/536 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575565
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.750