DRSC/TRiP Functional Genomics Resources

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Protein Alignment alpha-Est4 and Nceh1

DIOPT Version :10

Sequence 1:NP_524266.1 Gene:alpha-Est4 / 40906 FlyBaseID:FBgn0015572 Length:541 Species:Drosophila melanogaster
Sequence 2:NP_848887.1 Gene:Nceh1 / 320024 MGIID:2443191 Length:408 Species:Mus musculus


Alignment Length:350 Identity:71/350 - (20%)
Similarity:115/350 - (32%) Gaps:108/350 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    93 ISVKTLNGDPMP------VMVYIHGGAFKGGDSSRRAWGPDYF------MKE--NVVYISIGHRL 143
            :.|:...|.|.|      .::|||||.:....:.     ..|:      |.|  |.|.:||.:||
Mouse    90 VEVRVFEGSPKPEEPLRRSVIYIHGGGWALASAK-----ISYYDQLCTTMAEELNAVIVSIEYRL 149

  Fly   144 GPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAA--NFNGDPERITIFGHSSGSMTVQLLLAS 206
            .|..:.    |:       .:.|||.|.::......  .:..||.|:.|.|.|:|.         
Mouse   150 VPQVYF----PE-------QIHDVIRATKYFLQPEVLDKYKVDPGRVGISGDSAGG--------- 194

  Fly   207 PQSEGLFHRAILLAGFSMELNRLPQMEYRLAKHLGYEGDNVDSQVLEFLLKADPALIVSA-DFFT 270
                                        .||..||.:...|.|...:..|:|....::.| ||.|
Mouse   195 ----------------------------NLAAALGQQFTYVASLKNKLKLQALVYPVLQALDFNT 231

  Fly   271 PLEKRQGHNMPFKPS-----------IESYSTPNAVLLAE--PIDLQRTT-------WSNRIPII 315
            | ..:|..|.|..|.           ..:|....|:::..  .:|::|..       |::.:|..
Mouse   232 P-SYQQSMNTPILPRHVMVRYWLDYFKGNYDFVEAMIVNNHTSLDVERAAALRARLDWTSLLPSS 295

  Fly   316 LGAN-------SGEGMSIFSFVKMNPSWLKEFQCNPE--RVLPWTLRNRCDPGQRRQLGQALIHH 371
            :..|       :|....:....::..:.........|  ..||.|....|:....|..| .:...
Mouse   296 IKKNYKPIMQTTGNARIVQEIPQLLDAAASPLIAEQEVLEALPKTYILTCEHDVLRDDG-IMYAK 359

  Fly   372 FCEAHGHELTVDHTNGLVELFTHGF 396
            ..|:.|..:|:||       |..||
Mouse   360 RLESAGVNVTLDH-------FEDGF 377

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-Est4NP_524266.1 alpha/beta hydrolases 8..529 CDD:473884 70/349 (20%)
Nceh1NP_848887.1 Abhydrolase_3 109..381 CDD:400284 66/330 (20%)
Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3 113..115 1/1 (100%)

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