DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est4 and CG6414

DIOPT Version :9

Sequence 1:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster

Alignment Length:	569	Identity:	183/569 - (32%)
Similarity:	266/569 - (46%)	Gaps:	86/569 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SDDYNEDAPVVQTTHGK-VRGILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDC 65
            ||..|.....|:.:||. :.|..|.:.......||.|:|||.|||..|||:.|....||.|.|..
  Fly    22 SDGRNSQCLHVRLSHGGWLIGRHLTTHNGRHMRAFMGVPYAEPPLDDLRFRPPVPKAPWEGERLA 86

  Fly    66 SKPLSKCLQVSTLTKE--VEGSEDCLYLNISV---KTLNGDPMPVMVYIHGGAFKGGDSSRRAWG 125
            .|....|||.....::  :||||||||||:..   ...||. :||||:.|||.::.|......:|
  Fly    87 IKDAPICLQRDPFRRDMILEGSEDCLYLNVYTPERPRTNGS-LPVMVWFHGGGWQCGSGISSFYG 150

  Fly   126 PDYFMKENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITI 190
            ||:.:..::|.:|...|||||||||..  .|:.|||.||||.:..|.|:|||.|:|.|||..:|:
  Fly   151 PDFLLDHDIVLVSANFRLGPLGFLSTE--TLDCPGNNGLKDQLEVLHWVRANIASFGGDPNSVTV 213

  Fly   191 FGHSSGSMTVQLLLASPQSEGLFHRAILLAGFSMELNRLPQMEY---------RLAKHLGYEGDN 246
            ||.|:|..:|...:.|.:|.||.||.|..:|  ...|...|..:         :||:.:|.....
  Fly   214 FGESAGGASVTYHMLSEKSRGLLHRGIAQSG--TYFNPWAQPAHKGVAAGRATKLAQIVGCGNAG 276

  Fly   247 VDSQVLEFLLKADPALIVSADF------FTPLEKRQGHNMPFKPSIE-----SYSTPNAVLLAEP 300
            ...:.||.|.|.....||::.:      |.|:       :||.|.:|     ::.|......|:|
  Fly   277 EWPEKLECLRKKPAEDIVASLYDMFVWDFDPM-------IPFPPVVEPEHDGAFLTVAPRQAAKP 334

  Fly   301 IDLQRTTWSNRIPIILGANSGEGMSIFSFVKMNPSWLKEFQCNPERVLPWTLR-NRCDPGQRRQL 364
            ..||       :|:::||.:.||:...:.:...|..|.||:...|:|||..|. :..|...|:.:
  Fly   335 HGLQ-------LPLMVGATAEEGLLKTAALLNLPQLLAEFKSQFEQVLPVVLNYDHHDDSVRQTI 392

  Fly   365 GQALIHHFCEAHGHELTVDHTNGLVELFTHG-FVHAMDRLIQSRLTYGQ-APTYLYRFDFDSPDF 427
            .|. |..|....||:....:...|.:|.:.| ||..:|..::.|::... ||||:|.||.... .
  Fly   393 TQR-IESFYFKSGHDYDKANHQNLTDLISDGWFVAGIDEYLRLRMSQEDVAPTYVYLFDHKGA-A 455

  Fly   428 NFYRIRFMG--KEQRGVGHVDELGYIFKLPATFKLDKSRPEFTA---------IRRLVA-MFVQF 480
            :|..| |.|  .|..|..|.:||.|:|.:        .|..|.:         :|.|:. ::|.|
  Fly   456 SFTEI-FKGGRNEFYGACHAEELQYLFPI--------GRELFVSAVPTQKDLELRELMLHLWVSF 511

  Fly   481 AATSDPNAPLTKS--LVDWKPVT-------RFGKRM-----VLNISEEL 515
            |.|.:|| |...|  |.:|.|.:       |.|.:|     :..:..||
  Fly   512 AKTGNPN-PTNVSFHLPNWSPASSYPVEFARLGTKMEDSASIFRLENEL 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	180/564 (32%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	53/114 (46%)
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	179/555 (32%)
CG6414	NP_001303565.1	Aes	<116..>254	CDD:223730	58/142 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	7	6.860