Protein Alignment alpha-Est4 and Nceh1

DIOPT Version :10

• Sequence 1: NP_524266.1
• Gene: alpha-Est4 / 40906
• FlyBaseID: FBgn0015572
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_001120996.1
• Gene: Nceh1 / 294930
• RGDID: 1311104
• Length: 408
• Species: Rattus norvegicus
• Alignment Length: 441
• Identity: 90/441 - (20%)
• Similarity: 140/441 - (31%)
• Gaps: 156/441 - (35%)

  Fly    32 FYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLSKCLQVSTLTKEVEGSEDCLYLN---- 92
            :|.:..:|.||.             .||. :...........|||.|...:..|...:.||
  Rat    17 YYVYIPLPSAVS-------------DPWK-LMLLDATFRGAQQVSNLIHSLGLSHHLITLNFIII 67

  Fly    93 ----------------------ISVKTLNGDPMP------VMVYIHGGAFKGGDSSRRAWGPDYF 129
                                  :.|:...|.|.|      .:||||||.:....:.     ..|:
  Rat    68 SFGKKSARSSPRVKVTDTDFDGVEVRVFEGPPKPDEPLRRSVVYIHGGGWALASAK-----ISYY 127

  Fly   130 ------MKE--NVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAA--NFNGD 184
                  |.|  |.|.:||.:||.|..:.    |:       .:.|||.|.::......  .:..|
  Rat   128 DQLCTAMAEELNAVIVSIEYRLVPQVYF----PE-------QIHDVIRATKYFLQPEVLDKYKVD 181

  Fly   185 PERITIFGHSSGSMTVQLLLASPQSEGLFHRAILLAGFSMELNRLPQMEYRLAKHLGYEGDNVDS 249
            |.|:.:.|.|:|.                                     .||..||.:...|:|
  Rat   182 PGRVGVSGDSAGG-------------------------------------NLAAALGQQFTYVES 209

  Fly   250 QVLEFLLKADPALIV----SADFFTPLEKRQGHNMPFKPS-------IE----SYSTPNAVLLAE 299
              |:..||.. |||.    :.||.|| ..:|..|.|..|.       ::    :|....|:::..
  Rat   210 --LKNKLKLQ-ALIYPVLQALDFNTP-SYQQSMNTPILPRHVMVRYWVDYFKGNYDFVEAMIVNN 270

  Fly   300 --PIDLQRTT-------WSNRIPIILGANSGEGMSIFS---FVKMNPSWLKEFQCNP-------E 345
              .:|::|..       |::.:|..:..|....:....   .||..|. |.:...:|       .
  Rat   271 HTSLDVERAAALRARLDWTSLLPSSIKKNYKPVLQTIGDARIVKEIPQ-LLDAAASPLIAEQEVL 334

  Fly   346 RVLPWTLRNRCDPGQRRQLGQALIHHFCEAHGHELTVDHTNGLVELFTHGF 396
            :.||.|....|:....|..| .:.....|:.|..:|:||       |..||
  Rat   335 QALPKTYILTCEHDVLRDDG-IMYAKRLESAGVNVTLDH-------FEDGF 377

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	alpha/beta hydrolases	8..529	CDD:473884	90/441 (20%)
Nceh1	NP_001120996.1	Abhydrolase_3	109..381	CDD:400284	73/335 (22%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	113..115		1/1 (100%)