DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est4 and Ces1e

DIOPT Version :9

Sequence 1:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_113753.2	Gene:	Ces1e / 29225	RGDID:	621508	Length:	561	Species:	Rattus norvegicus

Alignment Length:	547	Identity:	163/547 - (29%)
Similarity:	239/547 - (43%)	Gaps:	114/547 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PVVQTTHGKVRG--ILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRD-------C 65
            |||.|..|||.|  :.|:. :.:....|.|:|:|.||||:|||..|...:||..:::       |
  Rat    24 PVVDTLQGKVLGKYVSLEG-FTQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTSYPPMC 87

  Fly    66 SK-PLSKCLQVSTLTKEVEG-----SEDCLYLNI--SVKTLNGDPMPVMVYIHGGAFKGGDSSRR 122
            |: |::..:....||...|.     |||||||||  .......|.:||||:||||....|.:|..
  Rat    88 SQDPVAGQIVNDLLTNREENISLQFSEDCLYLNIYTPADLTKRDRLPVMVWIHGGGLVLGGASTY 152

  Fly   123 AWGPDYFMKENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPER 187
            . |......||||.:.|.:|||..||.|..|....  ||.|..|.:.||.|::.|..||.|||..
  Rat   153 D-GLALSTHENVVVVVIQYRLGIWGFFSTGDEHSR--GNWGHLDQVAALHWVQDNIDNFGGDPGS 214

  Fly   188 ITIFGHSSGSMTVQLLLASPQSEGLFHRAILLAGFSM-----ELNRLPQMEYRLAKHLGYEG--- 244
            :||||.|:|..:|.:|:.||.::.|||:||..:|.::     :.|..|..| ::|...|.:.
  Rat   215 VTIFGESAGGESVSVLVLSPLAKNLFHKAISESGVALTAGLVKKNTRPLAE-KIAVVSGCKSTTS 278

  Fly   245 --------DNVDSQVLEFLLKADPALIVSADFFTPLEKRQGHNMPFKPSIESYSTPNAVLLAEPI 301
                    ...:.::||..||.:   :.|.|...  :.||.:  ||.|::    ....||...|.
  Rat   279 AAMVHCLRQKTEEELLETTLKLN---LFSLDLHG--DSRQSY--PFVPTV----LDGVVLPKMPE 332

  Fly   302 DLQRTTWSNRIPIILGANSGEGMSIF--------SFVKMNP----SWLKE--FQCN-PERVLPWT 351
            ::......|.:|.|:|.|..|...|.        |.:|::|    |.||:  |..| ||..:|..
  Rat   333 EILAEKDFNTVPYIVGINKQEFGWILPTMMNYPPSDMKLDPMTATSLLKKSSFLLNLPEEAIPVA 397

  Fly   352 ----LRNRCDPGQRRQLGQALIHHFCEAHGHELTVDHTNGLVELFTHGFVHAMDRLIQSRLTYGQ 412
                ||:..||.:.:                       :.|:||. ...:..:..:|.||   |.
  Rat   398 VEKYLRHTDDPDRNK-----------------------DQLLELI-GDVIFGVPSVIVSR---GH 435

  Fly   413 ----APTYLYRFDFDSPDFNFYRIRFMGKEQRG--VG-HVDELGYIFKLPATFKLDKSRPEFTAI 470
                |.||:|.|.        ||..|..|.:..  || |.||:..:|..| ..:...|:.|....
  Rat   436 RDAGARTYMYEFQ--------YRPSFSSKMKPSTVVGDHGDEIYSVFGAP-ILRGGTSKEEINLS 491

  Fly   471 RRLVAMFVQFAATSDPNAPLTKSLVDW 497
            :.::..:..||...:||.   :.|..|
  Rat   492 KMMMKFWANFARNGNPNG---QGLPHW 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	163/547 (30%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	51/114 (45%)
Ces1e	NP_113753.2	COesterase	24..545	CDD:278561	163/547 (30%)
		Aes	43..>239	CDD:223730	76/198 (38%)
		Prevents secretion from ER (Potential)	558..561
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910