DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est4 and Ces4a

DIOPT Version :9

Sequence 1:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_001099646.1	Gene:	Ces4a / 291955	RGDID:	1307418	Length:	563	Species:	Rattus norvegicus

Alignment Length:	580	Identity:	173/580 - (29%)
Similarity:	258/580 - (44%)	Gaps:	115/580 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PVVQTTHGKVRGILLKSLY--DEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLSKC 72
            |::.|.||.::|   |.::  |.....|.|:|::.||:||.||..|....||:||||.:.....|
  Rat    34 PLLITKHGILQG---KQVHVGDTPIRVFLGVPFSQPPVGTRRFAPPEPPLPWNGIRDATTYPPSC 95

  Fly    73 LQVS---------TLTKEVEG---SEDCLYLNISVKTL-NGDP-MPVMVYIHGGAFKGGDSSRRA 123
            ||.|         ...|:.|.   ||||||||:....| .||| :||||:..||||..|.:|...
  Rat    96 LQESWGQITSMYLNTRKQYEWLHFSEDCLYLNVYAPVLAPGDPLLPVMVWFPGGAFLVGSASTYE 160

  Fly   124 WGPDYFMKENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERI 188
             |.:...:..||.:.:.:|||.|||.|..:.  ...||.||.|.|.||||::.|...|.|||:.:
  Rat   161 -GSELAARGKVVLVFLQYRLGILGFFSTGNS--HARGNWGLLDQIAALRWVQENIEAFGGDPDSV 222

  Fly   189 TIFGHSSGSMTVQLLLASPQSEGLFHRAILLAGFSMELNRLPQMEYRLAKHLGYEG--DNVDSQV 251
            |:||.|:|:|:|..||.||.::||||:||..:|.::....:.....:.||.:.:..  |:..:::
  Rat   223 TLFGQSAGAMSVSGLLMSPLAQGLFHQAISQSGTAVLKTFITHDPLKSAKKIAHLAGCDHNSTKI 287

  Fly   252 LEFLLKADPA---LIVS--ADFFTPLEKRQGHNMP------FKPSIESYSTPNAVLLAEPIDLQR 305
            :...|||.||   ::||  ..||    :...|..|      ..|.::....|.     :|:.|..
  Rat   288 MVKCLKALPAEKVMLVSKKMTFF----RANSHKDPKDIVWFLSPVVDGLVFPE-----DPVVLLT 343

  Fly   306 TTWSNRIPIILGANSGEGMSIFSFVK--------MNPSWLKE--FQCN-----PERVLPWTLRNR 355
            ......:|.:||.||.|......|:.        ||.:::.:  :.|:     .|..:|..
  Rat   344 RGQVKPVPYLLGVNSAEFEWSLPFLMKLQLNQRIMNKNYITKLLWSCSILLNITEEQIPLV---- 404

  Fly   356 CDPGQRRQLGQALIHH---FCEAHGHELTVDHTNGLVELFTHGFVHAMDRLIQSRLTYGQAPTYL 417
                .|..|..|:.||   ....|..:|..|.|          ||:|..:..:.....| :|.||
  Rat   405 ----AREYLSDAISHHDWKMFRNHLIDLVGDAT----------FVYATLQAARYHRDAG-SPVYL 454

  Fly   418 YRFDFDSPDFNFYRIRFMGKEQRGVGHVDELGYIFKLPATFKLDKSR---PEFTAIRRLVAMFVQ 479
            |.|...:|..      .:.....|..|.|||.|:|..|  |....||   .||:.  :::..:..
  Rat   455 YEFKHHAPGI------IVKPRSDGADHGDELSYLFGSP--FSKGSSRGEEKEFSL--QMMKYWAN 509

  Fly   480 FAATSDPNAPLTKSLVDWKPVTRFGK-----------RMVLNISE-ELKF---IPQPEMP 524
            ||.|.|||   .:.|..|   .||.|           |:.:.:.| ::.|   :.||:.|
  Rat   510 FAHTGDPN---DRELPYW---PRFDKEEKYLQLDFDTRVGVKLREKQMTFWRRLRQPQKP 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	173/580 (30%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	52/114 (46%)
Ces4a	NP_001099646.1	COesterase	33..554	CDD:395084	169/569 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336427
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750