Protein Alignment alpha-Est4 and CES4A

DIOPT Version :9

• Sequence 1: NP_524266.1
• Gene: alpha-Est4 / 40906
• FlyBaseID: FBgn0015572
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: XP_011521323.1
• Gene: CES4A / 283848
• HGNCID: 26741
• Length: 628
• Species: Homo sapiens
• Alignment Length: 622
• Identity: 162/622 - (26%)
• Similarity: 257/622 - (41%)
• Gaps: 150/622 - (24%)

  Fly    10 PVVQTTHGKVRGILLKSLY--DEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCS------ 66
            |.|.|.:|.::|   |.::  ......|.|:|::.||||.|||..|...:||.||||.:
Human    50 PQVVTKYGTLQG---KQMHVGKTPIQVFLGVPFSRPPLGILRFAPPEPPEPWKGIRDATTYPPGW 111

  Fly    67 ------------------------------KPLS----KCLQ----------VSTLT--KEVEGS 85
                                          :|||    :|||          |||..  |.:..|
Human   112 SLALSPGWSAVARSRLTATSASRVQASLLPQPLSIWGYRCLQESWGQLASMYVSTRERYKWLRFS 176

  Fly    86 EDCLYLNI-SVKTLNGDP-MPVMVYIHGGAFKGGDSSRRAWGPDYFMKENVVYISIGHRLGPLGF 148
            |||||||: :.....||| :||||:..||||..|.:|... |.|...:|.||.:.:.||||..||
Human   177 EDCLYLNVYAPARAPGDPQLPVMVWFPGGAFIVGAASSYE-GSDLAAREKVVLVFLQHRLGIFGF 240

  Fly   149 LSL--NDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITIFGHSSGSMTVQLLLASPQSEG 211
            |..  ...|....||.||.|.:.||||::.|.|.|.|||..:|:||.|:|:|::..|:.||.:.|
Human   241 LRWRGRTDDSHARGNWGLLDQMAALRWVQENIAAFGGDPGNVTLFGQSAGAMSISGLMMSPLASG 305

  Fly   212 LFHRAILLAG---FSMELNRLPQMEYRLAKHLGYEGDNVDS-QVLEFLLKA-------------- 258
            ||||||..:|   |.:.:...|....:...||.  |.|.:| |:|...|:|
Human   306 LFHRAISQSGTALFRLFITSNPLKVAKKVAHLA--GCNHNSTQILVNCLRALSGTKVMRVSNKMR 368

  Fly   259 --------DPALIVSADFFTPLEKRQGHNMPFKPSIESYSTPNAVLLAEPIDLQRTTWSNRIPII 315
                    ||..|:               ....|.::....|:     :|:.|......:.:|.:
Human   369 FLQLNFQRDPEEII---------------WSMSPVVDGVVIPD-----DPLVLLTQGKVSSVPYL 413

  Fly   316 LGANSGEGMSIFSFVKMNPSWLKEFQCNPERV--LPWTLRNRCDPGQRRQLGQALIHHFCEAHGH 378
            ||.|:.|...:..::...|  |.......|.:  :.|:.|...:. .:.|:...:..:....:.|
Human   414 LGVNNLEFNWLLPYIMKFP--LNRQAMRKETITKMLWSTRTLLNI-TKEQVPLVVEEYLDNVNEH 475

  Fly   379 ELTVDHTNGLVELFTHG-FVHAMDRLIQSRLTYGQA--PTYLYRFDFDSPDFNFYRIRFMGKEQR 440
            :..: ..|.::::.... ||:|   .:|:...:..|  |.|||.|:..:      |...:.....
Human   476 DWKM-LRNRMMDIVQDATFVYA---TLQTAHYHRDAGLPVYLYEFEHHA------RGIIVKPRTD 530

  Fly   441 GVGHVDELGYIFKLPATFKLDKSRPEFTAIRRLVAMFVQFAATSDPNAPLTKSLVDWKPVTR--- 502
            |..|.||:.::|..|....|...:.:..:: :::..:..||.|.:||   ..:|..|....:
Human   531 GADHGDEMYFLFGGPFATGLSMGKEKALSL-QMMKYWANFARTGNPN---DGNLPCWPRYNKDEK 591

  Fly   503 -----FGKRMVLNISEELKFIPQPEMPKLKFFDRLYE 534
                 |..|:.:.:.|:          |:.|:..||:
Human   592 YLQLDFTTRVGMKLKEK----------KMAFWMSLYQ 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	159/615 (26%)
		Aes	<104..>219	CDD:223730	54/116 (47%)
CES4A	XP_011521323.1	COesterase	46..613	CDD:278561	159/615 (26%)
		Aes	<184..>291	CDD:223730	45/107 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142756
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3612
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.800