Protein Alignment alpha-Est4 and CES4A

DIOPT Version :10

• Sequence 1: NP_524266.1
• Gene: alpha-Est4 / 40906
• FlyBaseID: FBgn0015572
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: XP_011521323.1
• Gene: CES4A / 283848
• HGNCID: 26741
• Length: 628
• Species: Homo sapiens
• Alignment Length: 622
• Identity: 162/622 - (26%)
• Similarity: 257/622 - (41%)
• Gaps: 150/622 - (24%)

  Fly    10 PVVQTTHGKVRGILLKSLY--DEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCS------ 66
            |.|.|.:|.::|   |.::  ......|.|:|::.||||.|||..|...:||.||||.:
Human    50 PQVVTKYGTLQG---KQMHVGKTPIQVFLGVPFSRPPLGILRFAPPEPPEPWKGIRDATTYPPGW 111

  Fly    67 ------------------------------KPLS----KCLQ----------VSTLT--KEVEGS 85
                                          :|||    :|||          |||..  |.:..|
Human   112 SLALSPGWSAVARSRLTATSASRVQASLLPQPLSIWGYRCLQESWGQLASMYVSTRERYKWLRFS 176

  Fly    86 EDCLYLNI-SVKTLNGDP-MPVMVYIHGGAFKGGDSSRRAWGPDYFMKENVVYISIGHRLGPLGF 148
            |||||||: :.....||| :||||:..||||..|.:|... |.|...:|.||.:.:.||||..||
Human   177 EDCLYLNVYAPARAPGDPQLPVMVWFPGGAFIVGAASSYE-GSDLAAREKVVLVFLQHRLGIFGF 240

  Fly   149 LSL--NDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITIFGHSSGSMTVQLLLASPQSEG 211
            |..  ...|....||.||.|.:.||||::.|.|.|.|||..:|:||.|:|:|::..|:.||.:.|
Human   241 LRWRGRTDDSHARGNWGLLDQMAALRWVQENIAAFGGDPGNVTLFGQSAGAMSISGLMMSPLASG 305

  Fly   212 LFHRAILLAG---FSMELNRLPQMEYRLAKHLGYEGDNVDS-QVLEFLLKA-------------- 258
            ||||||..:|   |.:.:...|....:...||.  |.|.:| |:|...|:|
Human   306 LFHRAISQSGTALFRLFITSNPLKVAKKVAHLA--GCNHNSTQILVNCLRALSGTKVMRVSNKMR 368

  Fly   259 --------DPALIVSADFFTPLEKRQGHNMPFKPSIESYSTPNAVLLAEPIDLQRTTWSNRIPII 315
                    ||..|:               ....|.::....|:     :|:.|......:.:|.:
Human   369 FLQLNFQRDPEEII---------------WSMSPVVDGVVIPD-----DPLVLLTQGKVSSVPYL 413

  Fly   316 LGANSGEGMSIFSFVKMNPSWLKEFQCNPERV--LPWTLRNRCDPGQRRQLGQALIHHFCEAHGH 378
            ||.|:.|...:..::...|  |.......|.:  :.|:.|...:. .:.|:...:..:....:.|
Human   414 LGVNNLEFNWLLPYIMKFP--LNRQAMRKETITKMLWSTRTLLNI-TKEQVPLVVEEYLDNVNEH 475

  Fly   379 ELTVDHTNGLVELFTHG-FVHAMDRLIQSRLTYGQA--PTYLYRFDFDSPDFNFYRIRFMGKEQR 440
            :..: ..|.::::.... ||:|   .:|:...:..|  |.|||.|:..:      |...:.....
Human   476 DWKM-LRNRMMDIVQDATFVYA---TLQTAHYHRDAGLPVYLYEFEHHA------RGIIVKPRTD 530

  Fly   441 GVGHVDELGYIFKLPATFKLDKSRPEFTAIRRLVAMFVQFAATSDPNAPLTKSLVDWKPVTR--- 502
            |..|.||:.::|..|....|...:.:..:: :::..:..||.|.:||   ..:|..|....:
Human   531 GADHGDEMYFLFGGPFATGLSMGKEKALSL-QMMKYWANFARTGNPN---DGNLPCWPRYNKDEK 591

  Fly   503 -----FGKRMVLNISEELKFIPQPEMPKLKFFDRLYE 534
                 |..|:.:.:.|:          |:.|:..||:
Human   592 YLQLDFTTRVGMKLKEK----------KMAFWMSLYQ 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	alpha/beta hydrolases	8..529	CDD:473884	159/615 (26%)
CES4A	XP_011521323.1	COesterase	50..613	CDD:395084	159/615 (26%)