DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est4 and SPCC417.12

DIOPT Version :9

Sequence 1:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_588289.2	Gene:	SPCC417.12 / 2539430	PomBaseID:	SPCC417.12	Length:	539	Species:	Schizosaccharomyces pombe

Alignment Length:	489	Identity:	121/489 - (24%)
Similarity:	190/489 - (38%)	Gaps:	125/489 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 EQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRD--------CSKPLSKCLQVSTLTKEVEGSE 86
            |:.:.|.||.||.||:|.||::.|..|:..:....        |.:|.....:......:.:..|
pombe    35 EKCHRFTGIRYAKPPVGKLRWRRPVTLEDGYDYSGDYNQFKTICPQPFYNNRKNQVRNPDFKYDE 99

  Fly    87 DCLYLNISV----KTLNGDPMPVMVYIHGGAFKGGDSSR-RAWGPDYFMKE----NVVYISIGHR 142
            |||:|||.|    |...|  .||:.:||||..:.|:... |...|.....:    ..:.:|.|||
pombe   100 DCLFLNIWVPAGEKPAEG--WPVLYFIHGGWLQVGNPLHYRQCDPQDLQADGSPAKFILVSPGHR 162

  Fly   143 LGPLGFLSLNDPDLEVP--GNAGLKDVILALRWIRANAANFNGDPERITIFGHSSGSMTV--QLL 203
            |...|||:..:...|.|  .|.|..|..|.|.|...:..:|.|:.|.|.:.|.|:||.:.  ||:
pombe   163 LNLFGFLAGKELLEEDPKSSNFGFWDQRLGLEWTYKHIESFGGNKENIAVGGISAGSYSALFQLI 227

  Fly   204 LAS--PQSEGLFHRAILLA-GFSMELNRLPQMEYR---LAKHLGYEGDNVDSQVLEFLLKADP-- 260
            ..:  |::..:..||:||: |.|::...:.:.:.:   ||:..|...:...::.|| .|:|.|
pombe   228 YETYHPEANQIIKRALLLSNGLSVQPKSVEESQIQFNELAQKFGIPLELSSAEKLE-KLRAIPFQ 291

  Fly   261 --------------ALIVSADFFTPLEKRQGHNMPFKPSIESYSTPNAVLLAEPIDLQRTTWSNR 311
                          ..:...||..|        ..||                  |:...|:..|
pombe   292 DLADNILNLRLHTFRAVTDGDFVNP--------NTFK------------------DIYDGTFGKR 330

  Fly   312 I-----PIILGANSGEGMSIFSFVKMNPSWLKEFQCN------PERVLPWTLRNRCDPGQRRQLG 365
            |     .:|:|..:.| .||::  ..||...||...|      ||:|.
pombe   331 IRDSGRELIIGEVNNE-HSIYA--NTNPPKSKEDLFNQVNNYYPEKVT----------------- 375

  Fly   366 QALIHHFCEAHGHELTVDHTNGLVELF----THGFVHAMDRLIQSRLTYGQAP-TYLYRFDFDSP 425
            :||:..:.:....|...::...:..||    :...|:|..|::.:.|..|..| ..:||
pombe   376 KALLELYPKVPDMEDEKEYLAAIKALFGSIVSDMQVYASTRVLINGLVKGGVPLEKIYR------ 434

  Fly   426 DFNFYRIRFMGK-------EQRGVGHVDELGYIF 452
                |||.|.||       .:..|.|..:||..|
pombe   435 ----YRIAFRGKFFDKYEPPESLVPHAGDLGLWF 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	121/489 (25%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	38/125 (30%)
SPCC417.12	NP_588289.2	PnbA	20..534	CDD:225181	121/489 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43142
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.050