DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est4 and Ces2a

DIOPT Version :9

Sequence 1:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_653344.1	Gene:	Ces2a / 246252	RGDID:	708353	Length:	558	Species:	Rattus norvegicus

Alignment Length:	590	Identity:	171/590 - (28%)
Similarity:	257/590 - (43%)	Gaps:	126/590 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 EDAPVVQTTH-GKVRGILL-----KSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDC 65
            :.|..::.|| |:|||..:     ||    ..:.|.|||:|.||:|.|||..|.|.:||.|:||.
  Rat    28 DSASPIRNTHTGQVRGSFVHVKDTKS----GIHTFLGIPFAKPPVGPLRFAPPEDPEPWSGVRDA 88

  Fly    66 SKPLSKCLQVSTLT----KEVE-------GSEDCLYLNI--SVKTLNGDPMPVMVYIHGGAFKGG 117
            :...:.|||...:.    ||::       .|||||||||  ......|..:||||:||||....|
  Rat    89 TSQPAMCLQTDIMNLDGIKEMKLTVHPTPMSEDCLYLNIYTPAHAREGSNLPVMVWIHGGGLVLG 153

  Fly   118 -----DSSRRAWGPDYFMKENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRAN 177
                 |:|..|      ..|.:|.:||.:|||.|||.|..|.:..  ||.|..|.:.||||::.|
  Rat   154 SASMNDASTLA------ATEEIVIVSIQYRLGVLGFFSTGDQNAR--GNWGYLDQVAALRWVQQN 210

  Fly   178 AANFNGDPERITIFGHSSGSMTVQLLLASPQSEGLFHRAILLAGFSMELNRLP-------QMEYR 235
            .|.|.|:..::||||.|:|..:|...:.||.|:||||.||:.:|.::    ||       ::.|:
  Rat   211 IAYFGGNHGKVTIFGGSAGGTSVSSHVVSPMSKGLFHGAIMQSGVAL----LPDLISDKSEVVYK 271

  Fly   236 LAKHL-GYEGDNVDSQVLEFLLKADPALIVSADFFTPLEKRQGHNMPFK--PSIESYSTPNAVLL 297
            ...:| |.|..  ||:.|...|:|.....:.|           .|..||  |.:    .....|.
  Rat   272 TVANLSGCEAP--DSEALIRCLRAKSKQEILA-----------INQVFKMIPGV----VDGKFLP 319

  Fly   298 AEPIDLQRTTWSNRIPIILGANSGE-GMSIFSFVKMNPSWLKEFQCNPERVLPWTLRNRCDPGQR 361
            ..|.:|..:...:.:|.|:|.|:.| |..|..|:.:: ..:|:.   ....||..|::..
  Rat   320 KHPQELLASGDFHPVPSIIGINTDECGWGIPVFLGLD-HIIKKI---TRETLPTVLKSTA----- 375

  Fly   362 RQLGQALIHHFC------EAHGHELTVDHTNGLVELFTH---GFVHAMDRLIQSRLTYGQAPTYL 417
               .|.::...|      |..|   ..::...|.|.|.|   .|:..:..|..:.....|||.|.
  Rat   376 ---AQMMLPPECIDLIMEEYMG---DTENPETLQEQFRHMLGDFMFVIPALQVAHFQRSQAPVYF 434

  Fly   418 YRFDFDSPDFNFYRIRFMGKEQRGVGHVDELGYIF---KLPATFKLDKSRPEFTAIRRLVAMFVQ 479
            |.|. ..|.|    |:.:........|.|::.::|   ....||  |.:..|....||::..:..
  Rat   435 YEFQ-HLPSF----IKQVRPSHVKADHGDDILFVFGSYLWGMTF--DLTEEEELLKRRVMKYWAN 492

  Fly   480 FAATSDPNAPLTKSLVDWKPVTRFGKRMVLNISEE-LKFIPQP------EMPKLKFF-----DRL 532
            ||.|.:||.   :.|..|.         ||:..|: |:...||      :..:|:|:     .::
  Rat   493 FARTGNPNG---EDLPHWP---------VLDHDEQYLQLNTQPAVGRALKARRLQFWTKTLPQKI 545

  Fly   533 YEMAG 537
            .|:.|
  Rat   546 QELKG 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	168/575 (29%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	52/119 (44%)
Ces2a	NP_653344.1	COesterase	30..537	CDD:395084	168/573 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336225
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.840