Protein Alignment alpha-Est4 and Nlgn3

DIOPT Version :9

• Sequence 1: NP_524266.1
• Gene: alpha-Est4 / 40906
• FlyBaseID: FBgn0015572
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_766520.2
• Gene: Nlgn3 / 245537
• MGIID: 2444609
• Length: 825
• Species: Mus musculus
• Alignment Length: 606
• Identity: 174/606 - (28%)
• Similarity: 247/606 - (40%)
• Gaps: 134/606 - (22%)

  Fly     9 APVVQTTHGKVRGILLKSLYDEQFYAFD---GIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLS 70
            ||.|.|..||:||..: .|..|.....|   |:|||.||:|..||..|.....|.|||:.:....
Mouse    38 APTVNTHFGKLRGARV-PLPSEILGPVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPP 101

  Fly    71 KCLQ-VSTLTKEV------------------EGSEDCLYLNISVKTLNGD--------------- 101
            .|.| :.|...||                  |.:|||||||:.|.|.:|.
Mouse   102 VCPQNIHTAVPEVMLPVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDGSGAKKQGEDLADNDGD 166

  Fly   102 ---------PMPVMVYIHGGAFKGG-----DSSRRA-WGPDYFMKENVVYISIGHRLGPLGFLSL 151
                     ..|||||||||::..|     |.|..| :|       ||:.|::.:|:|.|||||.
Mouse   167 EDEDIRDSGAKPVMVYIHGGSYMEGTGNMIDGSVLASYG-------NVIVITLNYRVGVLGFLST 224

  Fly   152 NDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITIFGHSSGSMTVQLLLASPQSEGLFHRA 216
            .|.  ...||.||.|.|.||||:..|.|.|.|||.|||:||...|:..|.||..|..|||||.||
Mouse   225 GDQ--AAKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSLLTLSHHSEGLFQRA 287

  Fly   217 ILLAGFSME---LNRLPQMEYRLAKHLGYEGDNVDSQVLEFLLKADPALIVSADFFTPLEKRQG- 277
            |:.:|.::.   :|      |:..|:.....|.|...||:.:...|.....||......:.:..
Mouse   288 IIQSGSALSSWAVN------YQPVKYTSLLADKVGCNVLDTVDMVDCLRQKSAKELVEQDIQPAR 346

  Fly   278 HNMPFKPSIESYSTPNAVLLAEPIDLQRTTWSNRIPIILGANSGEGMSIFSFVKMNPSWLKEFQC 342
            :::.|.|.|:....|:     :|..|..........|:||.|.|||:   .||        |...
Mouse   347 YHVAFGPVIDGDVIPD-----DPEILMEQGEFLNYDIMLGVNQGEGL---KFV--------EGVV 395

  Fly   343 NPE-----RVLPWTLRNRCD-----PGQRRQLGQALIHHFCEAHGHELTVDHTNGLVELFT-HGF 396
            :||     ....:::.|..|     |..:..|.:.:...:.:....:........||.||| |.:
Mouse   396 DPEDGVSGTDFDYSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADRDNPETRRKTLVALFTDHQW 460

  Fly   397 VHAMDRLIQSRLTYGQAPTYLYRFDFDSPDFNFYRIRFMGKEQ-RGVGHVDELGYIFKLPAT--- 457
            |............|| :|||.|.|        ::..:.:.|.. ....|.||:.|:|.:|..
Mouse   461 VEPSVVTADLHARYG-SPTYFYAF--------YHHCQSLMKPAWSDAAHGDEVPYVFGVPMVGPT 516

  Fly   458 --FKLDKSRPEFTAIRRLVAMFVQFAATSDPNAPLTKSLVDWKPVTRFGKRMVLNISEEL---KF 517
              |..:.|:.:......::..:..||.|.|||.|:.:.       |:| .....|..||:   |:
Mouse   517 DLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNKPVPQD-------TKF-IHTKANRFEEVAWSKY 573

  Fly   518 IPQPEMPKLKFFDRLYEMAGV 538
            .|:         |:||...|:
Mouse   574 NPR---------DQLYLHIGL 585

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	170/595 (29%)
		Aes	<104..>219	CDD:223730	59/120 (49%)
Nlgn3	NP_766520.2	COesterase	39..601	CDD:365897	173/605 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	151..172		0/20 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	622..668

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832447
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740