DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est4 and Ces1c

DIOPT Version :9

Sequence 1:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	XP_006255234.2	Gene:	Ces1c / 24346	RGDID:	2571	Length:	551	Species:	Rattus norvegicus

Alignment Length:	548	Identity:	158/548 - (28%)
Similarity:	236/548 - (43%)	Gaps:	129/548 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PVVQTTHGKVRG--ILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRD-------C 65
            |||.||.|||.|  :.|:. :.:....|.|:|:|.||||:|||..|...:||..:::       |
  Rat    26 PVVDTTKGKVLGKYVSLEG-FTQPVAVFLGVPFAKPPLGSLRFAPPEPAEPWSFVKNTTTYPPMC 89

  Fly    66 S------KPLSKCLQVSTLTKEVEGSEDCLYLNI--SVKTLNGDPMPVMVYIHGGAFKGGDSSRR 122
            |      |.|:..|........:|.|||||||||  .........:||||:||||....|.:|..
  Rat    90 SQDGVVGKLLADMLSTGKENIPLEFSEDCLYLNIYSPADLTKNSRLPVMVWIHGGGLIIGGASPY 154

  Fly   123 AWGPDYFMKENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPER 187
            : |......||||.::|.:|||..|..|..|....  ||....|.:.||||::.|.|||.|:|:.
  Rat   155 S-GLALSAHENVVVVTIQYRLGIWGLFSTGDEHSR--GNWAHLDQLAALRWVQDNIANFGGNPDS 216

  Fly   188 ITIFGHSSGSMTVQLLLASPQSEGLFHRAILLAGFSMELNRLPQMEYRLAKHLG-YEGDN----- 246
            :||||.|:|.::|.:|:.||.::.||||||..:|..:..|...:....:|:.:. ..|.|
  Rat   217 VTIFGESAGGVSVSVLVLSPLAKNLFHRAISESGVVLTTNLDKKNTQAVAQMIATLSGCNNTSSA 281

  Fly   247 ---------VDSQVLEFLLKADPALIVSADFFTPLEKRQGHNMPFKPSIESYSTPNAVLLAEPID 302
                     .::::||..:|.|     :....|.::   |..:|        .||..:|..:..
  Rat   282 AMVQCLRQKTEAELLELTVKLD-----NTSMSTVID---GVVLP--------KTPEEILTEKSF- 329

  Fly   303 LQRTTWSNRIPIILGANSGEGMSIFSFV----------------KMNPSWLKEFQCN---PERVL 348
                   |.:|.|:|.|..|    |.::                ||..|.|:.|..|   .|.|:
  Rat   330 -------NTVPYIVGFNKQE----FGWIIPTMMGNLLSEGRMNEKMASSLLRRFSPNLNISESVI 383

  Fly   349 PWT----LRNRCDPGQRRQLGQALIHHFCEAHGHELTVDHTNGLVELFTHGFVHAMDRLIQSRLT 409
            |..    ||...||.::::|                       |:::|:..|......|:...|.
  Rat   384 PAIIEKYLRGTDDPAKKKEL-----------------------LLDMFSDVFFGIPAVLMSRSLR 425

  Fly   410 YGQAPTYLYRFDFDSPDFNFYRIRFMGKEQ----RGVGHVDELGYIFKLPATFKLDKSRPEFTAI 470
            ...||||:|.|.        ||..|:..::    :| .|.||:..:|..|  |..:.:..|.|.:
  Rat   426 DAGAPTYMYEFQ--------YRPSFVSDQRPQTVQG-DHGDEIFSVFGTP--FLKEGASEEETNL 479

  Fly   471 RRLVAMF-VQFAATSDPNAPLTKSLVDW 497
            .:||..| ..||...:||.   :.|..|
  Rat   480 SKLVMKFWANFARNGNPNG---EGLPHW 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	158/548 (29%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	51/114 (45%)
Ces1c	XP_006255234.2	COesterase	24..534	CDD:395084	158/548 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820