DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est4 and Cel

DIOPT Version :9

Sequence 1:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_058693.2	Gene:	Cel / 24254	RGDID:	2331	Length:	612	Species:	Rattus norvegicus

Alignment Length:	563	Identity:	163/563 - (28%)
Similarity:	250/563 - (44%)	Gaps:	79/563 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VQTTHGKVRGI--LLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLSKCLQ 74
            |.|..|.|.|:  .|..|..:....|.|||:|...  ||...:.|  ..|.|....:....:|||
  Rat    26 VYTEGGFVEGVNKKLSLLGGDSVDIFKGIPFATAK--TLENPQRH--PGWQGTLKATDFKKRCLQ 86

  Fly    75 VSTLTKEVEGSEDCLYLNISV----KTLNGDPMPVMVYIHGGAFKGGDSSRRAW-------GPDY 128
            .:....:..|.||||||||.|    |.::.| :||||:|:||||..|......:       |.:.
  Rat    87 ATITQDDTYGQEDCLYLNIWVPQGRKQVSHD-LPVMVWIYGGAFLMGSGQGANFLKNYLYDGEEI 150

  Fly   129 FMKENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITIFGH 193
            ..:.||:.::..:|:|||||||..|.:|  |||.||:|..:|:.|::.|.|.|.|||:.|||||.
  Rat   151 ATRGNVIVVTFNYRVGPLGFLSTGDANL--PGNFGLRDQHMAIAWVKRNIAAFGGDPDNITIFGE 213

  Fly   194 SSGSMTVQLLLASPQSEGLFHRAILLAGFSME---LNRLPQMEYR-LAKHLGYEGDNVDSQVLEF 254
            |:|:.:|.|...||.::||..|||..:|.::.   :...|....: :||.:|...:  |:..:..
  Rat   214 SAGAASVSLQTLSPYNKGLIRRAISQSGVALSPWAIQENPLFWAKTIAKKVGCPTE--DTAKMAG 276

  Fly   255 LLK-ADPALIVSADFFTPLEKRQ---GHNMPFKPSIESYSTPNAVLLAEPIDLQRTTWSNR--IP 313
            .|| .||..:..| :..||:.::   .|.:.|.|.::....|:     :||:|    :.|.  |.
  Rat   277 CLKITDPRALTLA-YRLPLKSQEYPIVHYLAFIPVVDGDFIPD-----DPINL----YDNAADID 331

  Fly   314 IILGANSGEGMSIFSFVKMNPSWLKEFQCNPERVLPWTLRNRCDPGQRRQLG----QALIHHFCE 374
            .:.|.|..:| .:|:.|.: |:..|..|...|...     .|...|.....|    ||....:.|
  Rat   332 YLAGINDMDG-HLFATVDV-PAIDKAKQDVTEEDF-----YRLVSGHTVAKGLKGTQATFDIYTE 389

  Fly   375 AHGHELTVDHTNGLVELFTHGFVHAMD---RLIQSRLTYGQAPTYLYRFDFDS--PDFNFYRIRF 434
            :...:.:.::....|..|....:..:.   .|.|.|.....|.||.|.|...|  |.:.    ::
  Rat   390 SWAQDPSQENMKKTVVAFETDILFLIPTEMALAQHRAHAKSAKTYSYLFSHPSRMPIYP----KW 450

  Fly   435 MGKEQRGVGHVDELGYIFKLPATFKLDKSRPEFTAIRRLVAMFVQFAATSDPNAPLTKSLVDWKP 499
            ||.:     |.|:|.|:|..|....|.....:.|..:.::|.:..||.:.|||...:.....|.|
  Rat   451 MGAD-----HADDLQYVFGKPFATPLGYRAQDRTVSKAMIAYWTNFAKSGDPNMGNSPVPTHWYP 510

  Fly   500 -VTRFGKRMVLNISEELKFIPQPEMPK------LKFFDRLYEM 535
             .|..|..:.:|     |.|....|.:      |||:...:||
  Rat   511 YTTENGNYLDIN-----KKITSTSMKEHLREKFLKFWAVTFEM 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	160/555 (29%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	53/121 (44%)
Cel	NP_058693.2	COesterase	26..542	CDD:278561	160/555 (29%)
		Aes	<118..>247	CDD:223730	54/130 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	553..612
		4 X 11 AA tandem repeats, O-glycosylated region	556..599
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336396
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740