DRSC/TRiP Functional Genomics Resources

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Protein Alignment alpha-Est4 and CES3

DIOPT Version :10

Sequence 1:NP_524266.1 Gene:alpha-Est4 / 40906 FlyBaseID:FBgn0015572 Length:541 Species:Drosophila melanogaster
Sequence 2:NP_079198.2 Gene:CES3 / 23491 HGNCID:1865 Length:571 Species:Homo sapiens


Alignment Length:568 Identity:155/568 - (27%)
Similarity:233/568 - (41%) Gaps:134/568 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 PVVQTTHGKVRG--ILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLSKC 72
            |.|.||.|:|||  :.:|.. |.....|.|||:|.||||..||..||..:||.|:||.|.....|
Human    34 PEVDTTLGRVRGRQVGVKGT-DRLVNVFLGIPFAQPPLGPDRFSAPHPAQPWEGVRDASTAPPMC 97

  Fly    73 LQVSTLTKEVEG-----------------SEDCLYLNI--SVKTLNGDPMPVMVYIHGGAFKGG- 117
            ||      :||.                 |||||.||:  ..:...|...||||::||||...| 
Human    98 LQ------DVESMNSSRFVLNGKQQIFSVSEDCLVLNVYSPAEVPAGSGRPVMVWVHGGALITGA 156

  Fly   118 -----DSSRRAWGPDYFMKENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRAN 177
                 .|:..|:|       :||.:::.:|||.|||.|..|.  ..|||.|..||:.||||::.|
Human   157 ATSYDGSALAAYG-------DVVVVTVQYRLGVLGFFSTGDE--HAPGNQGFLDVVAALRWVQEN 212

  Fly   178 AANFNGDPERITIFGHSSGSMTVQLLLASPQSEGLFHRAILLAGFSMELNRLPQMEYRLAKHLGY 242
            .|.|.||...:|:||.|:|...:..|:.||.:.|||||||..:|.......:....:.||:.:  
Human   213 IAPFGGDLNCVTVFGGSAGGSIISGLVLSPVAAGLFHRAITQSGVITTPGIIDSHPWPLAQKI-- 275

  Fly   243 EGDNVDSQVLEFLLKADPALIVSADFFTPLEKRQGHNM----PFKPSIESYSTPNAVLLAEPIDL 303
                  :..|. ...:.||.:|..     |::::|..:    ..|.:|...:....|....|.:|
Human   276 ------ANTLA-CSSSSPAEMVQC-----LQQKEGEELVLSKKLKNTIYPLTVDGTVFPKSPKEL 328

  Fly   304 QRTTWSNRIPIILGANSG----------------EGMSIFSFVKMNPSWLKEFQCNPE---RVLP 349
            .:....:.:|.::|.|:.                |.||....:.::...|......||   .|:.
Human   329 LKEKPFHSVPFLMGVNNHEFSWLIPRGWGLLDTMEQMSREDMLAISTPVLTSLDVPPEMMPTVID 393

  Fly   350 WTLRNRCDPGQRRQLGQALIHHFCEAHGHELTVDHTNGLVELFTHGFVHAMDRLIQSRLTYGQAP 414
            ..|.:..|       .||....|.|..|            ::|.:....:..|.::.    ..:|
Human   394 EYLGSNSD-------AQAKCQAFQEFMG------------DVFINVPTVSFSRYLRD----SGSP 435

  Fly   415 TYLYRFDFDSPDFNFYRIRFMGKEQRGVGHVDELGYIFKLPATFKLDKSR----PEFTAIRR--- 472
            .:.|.|......|...:..::..:     |..|..::|..|  |.:|:|.    ||.|...:   
Human   436 VFFYEFQHRPSSFAKIKPAWVKAD-----HGAEGAFVFGGP--FLMDESSRLAFPEATEEEKQLS 493

  Fly   473 --LVAMFVQFAATSDPNAPLTKSLVDW------------KPVTRFGKR 506
              ::|.:..||.|.|||   :|:|..|            .||.|.|::
Human   494 LTMMAQWTHFARTGDPN---SKALPPWPQFNQAEQYLEINPVPRAGQK 538

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-Est4NP_524266.1 alpha/beta hydrolases 8..529 CDD:473884 155/568 (27%)
CES3NP_079198.2 COesterase 32..547 CDD:395084 155/568 (27%)
Prevents secretion from ER. /evidence=ECO:0000255 568..571
Blue background indicates that the domain is not in the aligned region.

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