Protein Alignment alpha-Est4 and Ces4a

DIOPT Version :10

• Sequence 1: NP_524266.1
• Gene: alpha-Est4 / 40906
• FlyBaseID: FBgn0015572
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_666325.2
• Gene: Ces4a / 234677
• MGIID: 2384581
• Length: 563
• Species: Mus musculus
• Alignment Length: 567
• Identity: 163/567 - (28%)
• Similarity: 251/567 - (44%)
• Gaps: 87/567 - (15%)

  Fly    10 PVVQTTHGKVRGILLKSLY--DEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLSKC 72
            |::.|.||.::|   |.::  |.....|.|||::.||:||.||..|....||:||||.:.....|
Mouse    34 PLLITKHGILQG---KQVHVGDTPIQVFLGIPFSKPPVGTRRFAPPEPPLPWNGIRDATTYPPSC 95

  Fly    73 LQVS------------TLTKEVEGSEDCLYLNISVKTL-NGDP-MPVMVYIHGGAFKGGDSSRRA 123
            ||.|            ...|.:..||||||||:....| .|.| :||||:..||||..|.:|...
Mouse    96 LQESWGQILSMYLNTRKQYKWLHFSEDCLYLNVYAPVLAPGAPLLPVMVWFPGGAFLAGSASTYE 160

  Fly   124 WGPDYFMKENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERI 188
             |.:...:..||.:.:.:|||.|||.|..:.  ...||.||.|.|.||||::.|...|.|||:.:
Mouse   161 -GSELAARGKVVLVFLQYRLGILGFFSTGNS--HARGNWGLLDQIAALRWVQENIEAFGGDPDSV 222

  Fly   189 TIFGHSSGSMTVQLLLASPQSEGLFHRAILLAGFSM---ELNRLPQMEYRLAKHLGYEGDNVDSQ 250
            |:||.|:|:|:|..|:.||.::||||:||..:|.::   .:...|....:...||.....|....
Mouse   223 TLFGQSAGAMSVSGLMVSPLAQGLFHQAISQSGTAVLKAFITPDPLTSAKKIAHLAGCDHNSTKV 287

  Fly   251 VLEFL--LKADPALIVS--ADFFTPLEKRQGHNMP------FKPSIESYSTPNAVLLAEPIDLQR 305
            ::|.|  |.|:...:||  ..||    :...|..|      ..|.::....|.     :|:.|..
Mouse   288 MVECLRSLSAEEVTLVSKRMSFF----QANSHKDPKEIVWFLSPVVDGVVFPE-----DPVVLLT 343

  Fly   306 TTWSNRIPIILGANSGE---GMSIFSFVKMNPSWLKEFQCNPERVLPWTL-------RNRCDPGQ 360
            ......:|.:||.|:.|   .:.....:::|...:.  |.|..::| |:.       :.:.....
Mouse   344 RGQVKPVPYLLGVNNAEFEWNLPFLMKIQLNQRMMN--QTNINKIL-WSFNVLLNITKEQVPVVA 405

  Fly   361 RRQLGQALIHHFCEAHGHELTVDHTNGLVELFTHG-FVHAMDRLIQSRLTYGQAPTYLYRFDFDS 424
            |..|..|:.:|..:.        ..|.|::|.... ||:|..:..:.....| :|.|||.|...:
Mouse   406 REYLNDAISNHDWKM--------FRNRLIDLIGDATFVYATLQAARYHRDAG-SPVYLYEFKHHA 461

  Fly   425 PDFNFYRIRFMGKEQRGVGHVDELGYIFKLPATFKLDKS---RPEFTAIRRLVAMFVQFAATSDP 486
            ..      ..:.|...|..|.|||.|:|..|  |....|   ..||:.  :::..:..||.|.:|
Mouse   462 SS------GIIIKPYNGADHGDELSYLFGSP--FSKGSSAGEEKEFSL--QMMKYWANFAHTGNP 516

  Fly   487 NAPLTKSLVDWKPVTRFGK-RMVLNISEELKFIPQPEMPKLKFFDRL 532
            |.   :.|..|   .||.| ...|.:..:.:...:.:..|:.|:.:|
Mouse   517 NG---EKLPYW---PRFDKDEKYLQLDFDTRVGVKLKEKKMAFWSQL 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	alpha/beta hydrolases	8..529	CDD:473884	161/562 (29%)
Ces4a	NP_666325.2	COesterase	33..554	CDD:395084	161/562 (29%)