DRSC/TRiP Functional Genomics Resources

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Protein Alignment alpha-Est4 and Ces2c

DIOPT Version :10

Sequence 1:NP_524266.1 Gene:alpha-Est4 / 40906 FlyBaseID:FBgn0015572 Length:541 Species:Drosophila melanogaster
Sequence 2:NP_663578.1 Gene:Ces2c / 234671 MGIID:2385905 Length:561 Species:Mus musculus


Alignment Length:555 Identity:164/555 - (29%)
Similarity:234/555 - (42%) Gaps:128/555 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 DYNEDAPVVQTTHGKVRGILLKSLYDEQ--FYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCS 66
            |..|..|:..|..|:::|.|: .:.|.:  .:.|.|||:|.||:|.|||..|...:||.|:||.:
Mouse    28 DSPEANPIRNTHTGQIQGSLI-HVKDTKAGVHTFLGIPFAKPPVGPLRFAPPEAPEPWSGVRDGT 91

  Fly    67 KPLSKCLQ------------VSTLTKEVEGSEDCLYLNI--SVKTLNGDPMPVMVYIHGGAFKGG 117
            ...:.|||            :..:......|||||||||  ......|..:||||:|||||...|
Mouse    92 AHPAMCLQNLDMLNEAGLPDMKMMLSSFPMSEDCLYLNIYTPAHAHEGSNLPVMVWIHGGALVIG 156

  Fly   118 DSSRRAWGPDYFMKENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFN 182
            .:|... |....:.|::|.::|.:|||.|||.|..|.  ...||.|..|...||||::.|.|:|.
Mouse   157 MASMFD-GSLLTVNEDLVVVTIQYRLGVLGFFSTGDQ--HARGNWGYLDQAAALRWVQQNIAHFG 218

  Fly   183 GDPERITIFGHSSGSMTVQLLLASPQSEGLFHRAILLAGFSMELNRLPQM--------EYRLAKH 239
            |:|:|:||||.|:|..:|...:.||.|:||||.||:.:|.::    ||.:        ...:||.
Mouse   219 GNPDRVTIFGESAGGTSVSSHVVSPMSQGLFHGAIMESGVAL----LPDLISETSEMVSTTVAKL 279

  Fly   240 LGYEGDNVDSQVL----------EFL-----LKADPALIVSADFFTPLEKRQGHNMPFKPSIESY 289
            .|.|.  :|||.|          |.|     .|..|| :|..:||.                   
Mouse   280 SGCEA--MDSQALVRCLRGKSEAEILAINKVFKMIPA-VVDGEFFP------------------- 322

  Fly   290 STPNAVLLAEPIDLQRTTWSNRIPIILGANSGE-GMSI---FSFVKMNPSWLKEFQCNPERVLPW 350
            ..|..:|.:|..        :.:|.|:|.|:.| |.||   ....:|.....:|   |.:.||..
Mouse   323 RHPKELLASEDF--------HPVPSIIGVNNDEFGWSIPVVMGSAQMIKGITRE---NLQAVLKD 376

  Fly   351 TLRNRCDPGQRRQL-----------GQALIHHFCEAHGHELTVDHTNGLVELFTHGFVHAMDRLI 404
            |......|.:...|           .|.|...|.|..|                 .|:..:..|.
Mouse   377 TAVQMMLPPECSDLLMEEYMGDTEDAQTLQIQFTEMMG-----------------DFMFVIPALQ 424

  Fly   405 QSRLTYGQAPTYLYRFDFDSPDFNFYRIRFMGKEQRGVGHVDELGYIFKLPATF----KLDKSRP 465
            .:......||.|.|  :|..|...|..:|   .......|.||:.::|   |:|    |||.:..
Mouse   425 VAHFQRSHAPVYFY--EFQHPPSYFKDVR---PPHVKADHADEIPFVF---ASFFWGMKLDFTEE 481

  Fly   466 EFTAIRRLVAMFVQFAATSDPNAPLTKSLVDWKPV 500
            |....||::..:..||...:||   ::.|..| ||
Mouse   482 EELLSRRMMKYWANFARHGNPN---SEGLPYW-PV 512

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-Est4NP_524266.1 alpha/beta hydrolases 8..529 CDD:473884 162/551 (29%)
Ces2cNP_663578.1 COesterase 32..540 CDD:395084 162/551 (29%)
Prevents secretion from ER. /evidence=ECO:0000255 558..561
Blue background indicates that the domain is not in the aligned region.

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