Protein Alignment alpha-Est4 and Ces2b

DIOPT Version :10

• Sequence 1: NP_524266.1
• Gene: alpha-Est4 / 40906
• FlyBaseID: FBgn0015572
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_937814.1
• Gene: Ces2b / 234669
• MGIID: 2448547
• Length: 556
• Species: Mus musculus
• Alignment Length: 551
• Identity: 161/551 - (29%)
• Similarity: 232/551 - (42%)
• Gaps: 125/551 - (22%)

  Fly     4 DYNEDAPVVQTTHGKVRGILLKSLYDEQ--FYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCS 66
            |..|.:|:..|..|:|||.|: .:.|.:  .:.|.|||:|.||:|.|||..|...:||.|:||.:
Mouse    28 DSPEASPIRNTHTGQVRGSLV-HVKDTKAGVHTFLGIPFAKPPVGPLRFAPPEAPEPWSGVRDGT 91

  Fly    67 KPLSKCLQVSTLTKE-------VEGSEDCLYLNI--SVKTLNGDPMPVMVYIHGGAFKGG----- 117
            ...:.|||...:.||       |..|||||||||  ......|..:||||:||||....|
Mouse    92 AHPAMCLQNLGVMKEIKLKLPPVSTSEDCLYLNIYTPAHAHEGSNLPVMVWIHGGGLVAGMASMY 156

  Fly   118 DSSRRAWGPDYFMKENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFN 182
            |.|..|      ..|::|.::|.:|||.|||.|..|.  ...||.|..|.:.|||||:.|.|:|.
Mouse   157 DGSLLA------AIEDLVVVTIQYRLGVLGFFSTGDQ--HARGNWGFLDQVAALRWIQQNIAHFG 213

  Fly   183 GDPERITIFGHSSGSMTVQLLLASPQSEGLFHRAILLAGFSMELNRLP--------QMEYRLAKH 239
            |.|:|:||||.|:|..:|...:.||.|:||||.||:.:|.::    ||        .:...:||.
Mouse   214 GKPDRVTIFGESAGGTSVSSHVVSPMSKGLFHGAIMESGVAL----LPYLITDTSEMVSTTVAKL 274

  Fly   240 LGYEGDNVDSQVL---------------EFLLKADPALIVSADFFTPLEKRQGHNMPFKPSIESY 289
            .|.|.  :||:.|               ..|::..|| :|..:||.
Mouse   275 SGCEA--MDSEALVRCLRGKSEAEILAINKLVQMIPA-VVDGEFFP------------------- 317

  Fly   290 STPNAVLLAEPIDLQRTTWSNRIPIILGANSGEGMSIFSFVKMNPSWLKEF-QCNPERVLPWTLR 353
            ..|..:|.:|..        :.:|.|:|.|:.|.......|..:...:||. :.|.:.||
Mouse   318 RHPKELLASEDF--------HPVPSIIGVNNDEFGWTIPVVMGSAQTIKEITRENLQAVL----- 369

  Fly   354 NRCDPGQRRQLGQALIHHFCEAHGHELTVDHTNGLVE-------LFT---HGFVHAMDRLIQSRL 408
                   :....|.::...|.    :|.::...|..|       .||   ..|:..:..|..:..
Mouse   370 -------KNTTAQLMLPPECS----DLLMEEYMGDTEDAQTLQIQFTEMMEDFMFVIPALQVAYF 423

  Fly   409 TYGQAPTYLYRFDFDSPDFNFYRIRFMGKEQRGVGHVDEL----GYIFKLPATFKLDKSRPEFTA 469
            ....|..|.|.|..........|...:..:     |.||:    ||.|   ...|||.:..|...
Mouse   424 QRSHASVYFYEFQHQIASLKDVRPTHVKAD-----HADEIPFVFGYFF---WDMKLDFTEGEKLL 480

  Fly   470 IRRLVAMFVQFAATSDPNAPLTKSLVDWKPV 500
            .||::..:..||...:||   ::.|..| ||
Mouse   481 SRRMMKYWANFARHGNPN---SEGLPYW-PV 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	alpha/beta hydrolases	8..529	CDD:473884	159/547 (29%)
Ces2b	NP_937814.1	COesterase	32..535	CDD:395084	159/547 (29%)