DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est4 and Ces1f

DIOPT Version :9

Sequence 1:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_659179.1	Gene:	Ces1f / 234564	MGIID:	2142687	Length:	561	Species:	Mus musculus

Alignment Length:	568	Identity:	160/568 - (28%)
Similarity:	237/568 - (41%)	Gaps:	156/568 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PVVQTTHGKVRGILLKSLYDEQF----YAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRD------ 64
            |||.|.||||.|   |.:..|.|    ..|.|||:|.||||:|||..|...:||..:::
Mouse    24 PVVDTAHGKVLG---KHVNVEGFSQPVAVFLGIPFAKPPLGSLRFAPPQPAEPWSSVKNATTYPP 85

  Fly    65 -CSKPLSKCLQVSTL---TKE---VEGSEDCLYLNISVKT--LNGDPMPVMVYIHGGAFK-GGDS 119
             ||:..::...|:.|   .||   :|.|||||||||....  .....:||||:||||..| ||.|
Mouse    86 MCSQDAARGQAVNDLITNRKEKIHLEFSEDCLYLNIYTPADFSKNSRLPVMVWIHGGGLKLGGAS 150

  Fly   120 SRRAWGPDYFMKENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGD 184
            |..  |......||||.::|.:||...||.|..|....  ||.|..|.:.||.|::.|.|||.||
Mouse   151 SFD--GRALSAYENVVVVAIQYRLSIWGFFSTGDEHSR--GNWGHLDQVAALHWVQDNIANFGGD 211

  Fly   185 PERITIFGHSSGSMTVQLLLASPQSEGLFHRAILLAG-------FSMELNRLPQMEYRLAKHLGY 242
            |..:||||.|:|..:|.:|:.||.|:.||||||..:|       |:.::..:.:   ::|...|.
Mouse   212 PGSVTIFGESAGGYSVSILILSPLSKNLFHRAISESGVAFIPGMFTKDVRPITE---QIAVTAGC 273

  Fly   243 E-----------GDNVDSQVLEFLLKADPALIVSADFFTPLEKRQGHNMPFKPSIESYSTPNA-- 294
            :           ....:.::||.:.|.                    |: :|.|::. .|.|:
Mouse   274 KTTTSAVIVHCMRQKTEEELLEIMHKL--------------------NL-YKLSLQG-DTKNSDQ 316

  Fly   295 ---------VLLAEPIDLQRTTWSNRIPIILGANSGE------GMSIF--SFVKMNP----SWLK 338
                     ||..:|.::......|.:|.|:|.|..|      .|:.|  :.||::.    :.|:
Mouse   317 FVTSVLDGVVLPKDPKEILAEKNFNTVPYIVGINKQECGWLLPTMTGFLPADVKLDKKKAIALLE 381

  Fly   339 EFQCN---PERVLPWTL----RNRCDPGQRRQ-----LGQAL--IHHFCEAHGHELTVDHTNGLV 389
            :|...   ||.::|..:    :...||.|.|:     :|...  :.....:.||..|
Mouse   382 QFASMTGIPEDIIPVAVEKYTKGSDDPDQIREGVLDAMGDVAFGVPSVIVSRGHRDT-------- 438

  Fly   390 ELFTHGFVHAMDRLIQSRLTYGQAPTYLYRF----DFDSPDFNFYRIRFMGKEQRGVG-HVDELG 449
                                  .||||:|.:    .|.||.          :.:..|| |.|::.
Mouse   439 ----------------------GAPTYMYEYQYYPSFSSPQ----------RPKNVVGDHADDVY 471

  Fly   450 YIFKLPATFKLDKSRPEFTAIRRLVAMFVQFAATSDPNAPLTKSLVDW 497
            .:|..| ..:...|..|....:.::..:..||...:||.   |.|..|
Mouse   472 SVFGAP-ILREGASEEEINLSKMVMKFWANFARNGNPNG---KGLPHW 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	160/568 (28%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	56/115 (49%)
Ces1f	NP_659179.1	COesterase	24..545	CDD:278561	160/568 (28%)
		Aes	<121..>225	CDD:223730	46/107 (43%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	558..561
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832960
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750