Protein Alignment alpha-Est4 and Aadacl3

DIOPT Version :10

• Sequence 1: NP_524266.1
• Gene: alpha-Est4 / 40906
• FlyBaseID: FBgn0015572
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_001078972.1
• Gene: Aadacl3 / 230883
• MGIID: 2685281
• Length: 408
• Species: Mus musculus
• Alignment Length: 265
• Identity: 50/265 - (18%)
• Similarity: 87/265 - (32%)
• Gaps: 120/265 - (45%)

  Fly    21 GILLKSL---YDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLSKCLQVSTLTKEV 82
            |::.:.|   |..||.:|                 .|||||                   |.::.
Mouse    58 GMIFEKLGLCYAPQFASF-----------------LHDLKP-------------------LKRDP 86

  Fly    83 EGSEDCLYLNISVKTLNGDPMPV---------------MVYIHGGA----------------FKG 116
            :         :.||.|:...:||               :::.|||.                .|.
Mouse    87 D---------VVVKDLHFGTIPVKLYKPKKPSSIPRLGIIFFHGGGTIIGSLRTHNSICLRLSKE 142

  Fly   117 GDSSRRAWGPDYFMKENVVYISIGHRLGPL-GFLSLNDPDLEVPGNAGLKDVILALRWIRANAAN 180
            .||               |.:|:|:|..|: .:..:.|            |.::|......:...
Mouse   143 CDS---------------VVVSVGYRKSPMYKYPVMKD------------DCVVATTHFLESLDV 180

  Fly   181 FNGDPERITIFGHSSG----SMTVQLLLASP-----QSEGLFHRAILLAGF---SMELNR-LPQM 232
            :..||.|:...|.|.|    ::|.|:|:..|     :::.|.:..:.|..|   |.:.|| :|.:
Mouse   181 YGVDPARVVTCGDSVGGTAATVTSQMLVHRPDLPRIKAQILIYPLLQLIDFGSPSYQQNRNIPLL 245

  Fly   233 EYRLA 237
            .:.||
Mouse   246 SWDLA 250

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	alpha/beta hydrolases	8..529	CDD:473884	50/265 (19%)
Aadacl3	NP_001078972.1	Abhydrolase_3	116..379	CDD:400284	33/162 (20%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	120..122		1/1 (100%)