Protein Alignment alpha-Est4 and NLGN1

DIOPT Version :9

• Sequence 1: NP_524266.1
• Gene: alpha-Est4 / 40906
• FlyBaseID: FBgn0015572
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Alignment Length: 641
• Identity: 178/641 - (27%)
• Similarity: 255/641 - (39%)
• Gaps: 183/641 - (28%)

  Fly     1 MSDDYNEDAPVVQTTHGKVRGILLKSLYDE---QFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGI 62
            :|...::..|:|.|..||:||| .|.|.:|   ....|.|:|||.||.|..||:.|....||..|
Human    44 LSQKLDDVDPLVATNFGKIRGI-KKELNNEILGPVIQFLGVPYAAPPTGERRFQPPEPPSPWSDI 107

  Fly    63 RDCSKPLSKCLQ----------------------VSTLTKEVEGSEDCLYLNISVKTL------- 98
            |:.::....|.|                      ||:..:  :.|||||||||.|.|.
Human   108 RNATQFAPVCPQNIIDGRLPEVMLPVWFTNNLDVVSSYVQ--DQSEDCLYLNIYVPTEDGPLTKK 170

  Fly    99 ------------------NGDPMPVMVYIHGGAFKGG-----DSSRRA-WGPDYFMKENVVYISI 139
                              :|.|.|||||||||::..|     |.|..| :|       ||:.|::
Human   171 QTDDLGDNDGAEDEDIRDSGGPKPVMVYIHGGSYMEGTGNLYDGSVLASYG-------NVIVITV 228

  Fly   140 GHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITIFGHSSGSMTVQLLL 204
            .:|||.|||||..|.  ...||.||.|:|.||||...|...|.|||.|||:||..:|...|.||.
Human   229 NYRLGVLGFLSTGDQ--AAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLT 291

  Fly   205 ASPQSE---------GLFHRAILLAGFSMELNRLPQMEYRLAKHLGYE-GDNVDS--QVLEFLLK 257
            .|..||         |||.|||..:|.::....:.....:.|:.|..: |.||..  :::|.|.|
Human   292 LSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYARMLATKVGCNVSDTVELVECLQK 356

  Fly   258 ADPALIVSADFFTPLEKRQGHNMPFKPSIESYSTPNAVLLAEPIDLQRTTWSNRIPIILGANSGE 322
            .....:|..|.     :...:::.|.|.|:....|:     :|..|..........|:||.|.||
Human   357 KPYKELVDQDI-----QPARYHIAFGPVIDGDVIPD-----DPQILMEQGEFLNYDIMLGVNQGE 411

  Fly   323 GM---------------SIFSFVKMNPSWLKEFQCNPE--RVLPWTLR-------NRCDPGQRRQ 363
            |:               |.|.|...|  ::......||  .||..|::       :|.:|..||:
Human   412 GLKFVENIVDSDDGISASDFDFAVSN--FVDNLYGYPEGKDVLRETIKFMYTDWADRHNPETRRK 474

  Fly   364 LGQALIHHFCEAHGHELTVDHTNGLVELFT-HGFVHAMDRLIQSRLTYGQAPTYLYRFDFDSPDF 427
            .                       |:.||| |.:|............:| :|||.|.|
Human   475 T-----------------------LLALFTDHQWVAPAVATADLHSNFG-SPTYFYAF------- 508

  Fly   428 NFYRIRFMGKEQ----RGVGHVDELGYIFKLP-----ATFKLDKSRPEFTAIRRLVAMFVQFAAT 483
             ::..:   .:|    ....|.||:.|:..:|     ..|..:.|:.:......::..:..||.|
Human   509 -YHHCQ---TDQVPAWADAAHGDEVPYVLGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKT 569

  Fly   484 SDPNAPL---TKSL---------VDWKPVTRFGKRMVLNISEELKFIPQPEMPKLK 527
            .|||.|:   ||.:         |.|   ||:.::..|.:...||       |::|
Human   570 GDPNQPVPQDTKFIHTKPNRFEEVAW---TRYSQKDQLYLHIGLK-------PRVK 615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	177/635 (28%)
		Aes	<104..>219	CDD:223730	59/129 (46%)
NLGN1	NP_001352852.1	COesterase	53..626	CDD:365897	177/632 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142650
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740