DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment alpha-Est4 and CES5A

DIOPT Version :9

Sequence 1:NP_524266.1 Gene:alpha-Est4 / 40906 FlyBaseID:FBgn0015572 Length:541 Species:Drosophila melanogaster
Sequence 2:NP_001177087.1 Gene:CES5A / 221223 HGNCID:26459 Length:604 Species:Homo sapiens


Alignment Length:546 Identity:156/546 - (28%)
Similarity:237/546 - (43%) Gaps:114/546 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 FDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLSKCLQVST-------LTK----EVEGSEDC 88
            |.|:|:|.||||:|||..|....||..:|:.:...:.|||.|.       :.|    :...||||
Human    86 FLGVPFAAPPLGSLRFTNPQPASPWDNLREATSYPNLCLQNSEWLLLDQHMLKVHYPKFGVSEDC 150

  Fly    89 LYLNI--SVKTLNGDPMPVMVYIHGGAFKGGDSSRRAWGPDYFMKENVVYISIGHRLGPLGFLSL 151
            |||||  ......|..:||:|:..|||||.|.:|... |......|:|:.:.:.:|||..||.:.
Human   151 LYLNIYAPAHADTGSKLPVLVWFPGGAFKTGSASIFD-GSALAAYEDVLVVVVQYRLGIFGFFTT 214

  Fly   152 NDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITIFGHSSGSMTVQLLLASPQSEGLFHRA 216
            .|.  ..|||...||.:.||.|::.|...|.|||..:||||.|:|:::|..|:.||.::||||:|
Human   215 WDQ--HAPGNWAFKDQVAALSWVQKNIEFFGGDPSSVTIFGESAGAISVSSLILSPMAKGLFHKA 277

  Fly   217 ILLAGFSMELNRLPQME---YRLAKHL----GYEGDNV-DSQVLEFLLKADPALIVSADFFTPLE 273
            |:.:|.::    :|.:|   |..::.|    .:.|:|. ||:.|...|:..|    |.:..|..:
Human   278 IMESGVAI----IPYLEAHDYEKSEDLQVVAHFCGNNASDSEALLRCLRTKP----SKELLTLSQ 334

  Fly   274 KRQGHNMPFKPSIESYSTPNAVLLAEPIDLQRTTWSNRIPIILGANSGEGMSIFSFVKMNPSWLK 338
            |.:.    |...::....||     ||:||........||.|:|.|:.|                
Human   335 KTKS----FTRVVDGAFFPN-----EPLDLLSQKAFKAIPSIIGVNNHE---------------- 374

  Fly   339 EFQCN---PERVLPWTLRNRCDPGQRRQLGQALIHHFCEA-------------HG-HELTVDHTN 386
               |.   |.:..|..|     .|..:.|...||.:....             |. |.|| :..:
Human   375 ---CGFLLPMKEAPEIL-----SGSNKSLALHLIQNILHIPPQYLHLVANEYFHDKHSLT-EIRD 430

  Fly   387 GLVELFTHGFVHAMDRLIQSRLTYGQ---APTYLYRFDFDSPDFNFYRIRFMGKEQRGVGHVDEL 448
            .|::|....| ..:..||.:|  |.:   ||.|.|.|......|...:..|:..:     |.||:
Human   431 SLLDLLGDVF-FVVPALITAR--YHRDAGAPVYFYEFRHRPQCFEDTKPAFVKAD-----HADEV 487

  Fly   449 GYIFKLPATFKLD------KSRPEFTAIRRLVAMFVQFAATSDPNAPLTKSLVDWKP--VTRFGK 505
            .::|. .|..|.|      .:..|....|:::..:..||.|.:||.   ..|..|..  :|....
Human   488 RFVFG-GAFLKGDIVMFEGATEEEKLLSRKMMKYWATFARTGNPNG---NDLSLWPAYNLTEQYL 548

  Fly   506 RMVLNIS--EELKFIPQPEMPKLKFF 529
            ::.||:|  :.||      .|::.|:
Human   549 QLDLNMSLGQRLK------EPRVDFW 568

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-Est4NP_524266.1 Abhydrolase 7..529 CDD:304388 155/544 (28%)
Aes <104..>219 CDD:223730 48/114 (42%)
CES5ANP_001177087.1 COesterase 56..568 CDD:278561 155/544 (28%)
Aes <155..>258 CDD:223730 39/105 (37%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142608
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1516
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 216 1.000 Inparanoid score I3612
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000017
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.790

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