Protein Alignment alpha-Est4 and CES5A

DIOPT Version :10

• Sequence 1: NP_524266.1
• Gene: alpha-Est4 / 40906
• FlyBaseID: FBgn0015572
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_001177087.1
• Gene: CES5A / 221223
• HGNCID: 26459
• Length: 604
• Species: Homo sapiens
• Alignment Length: 546
• Identity: 156/546 - (28%)
• Similarity: 237/546 - (43%)
• Gaps: 114/546 - (20%)

  Fly    35 FDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLSKCLQVST-------LTK----EVEGSEDC 88
            |.|:|:|.||||:|||..|....||..:|:.:...:.|||.|.       :.|    :...||||
Human    86 FLGVPFAAPPLGSLRFTNPQPASPWDNLREATSYPNLCLQNSEWLLLDQHMLKVHYPKFGVSEDC 150

  Fly    89 LYLNI--SVKTLNGDPMPVMVYIHGGAFKGGDSSRRAWGPDYFMKENVVYISIGHRLGPLGFLSL 151
            |||||  ......|..:||:|:..|||||.|.:|... |......|:|:.:.:.:|||..||.:.
Human   151 LYLNIYAPAHADTGSKLPVLVWFPGGAFKTGSASIFD-GSALAAYEDVLVVVVQYRLGIFGFFTT 214

  Fly   152 NDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITIFGHSSGSMTVQLLLASPQSEGLFHRA 216
            .|.  ..|||...||.:.||.|::.|...|.|||..:||||.|:|:::|..|:.||.::||||:|
Human   215 WDQ--HAPGNWAFKDQVAALSWVQKNIEFFGGDPSSVTIFGESAGAISVSSLILSPMAKGLFHKA 277

  Fly   217 ILLAGFSMELNRLPQME---YRLAKHL----GYEGDNV-DSQVLEFLLKADPALIVSADFFTPLE 273
            |:.:|.::    :|.:|   |..::.|    .:.|:|. ||:.|...|:..|    |.:..|..:
Human   278 IMESGVAI----IPYLEAHDYEKSEDLQVVAHFCGNNASDSEALLRCLRTKP----SKELLTLSQ 334

  Fly   274 KRQGHNMPFKPSIESYSTPNAVLLAEPIDLQRTTWSNRIPIILGANSGEGMSIFSFVKMNPSWLK 338
            |.:.    |...::....||     ||:||........||.|:|.|:.|
Human   335 KTKS----FTRVVDGAFFPN-----EPLDLLSQKAFKAIPSIIGVNNHE---------------- 374

  Fly   339 EFQCN---PERVLPWTLRNRCDPGQRRQLGQALIHHFCEA-------------HG-HELTVDHTN 386
               |.   |.:..|..|     .|..:.|...||.:....             |. |.|| :..:
Human   375 ---CGFLLPMKEAPEIL-----SGSNKSLALHLIQNILHIPPQYLHLVANEYFHDKHSLT-EIRD 430

  Fly   387 GLVELFTHGFVHAMDRLIQSRLTYGQ---APTYLYRFDFDSPDFNFYRIRFMGKEQRGVGHVDEL 448
            .|::|....| ..:..||.:|  |.:   ||.|.|.|......|...:..|:..:     |.||:
Human   431 SLLDLLGDVF-FVVPALITAR--YHRDAGAPVYFYEFRHRPQCFEDTKPAFVKAD-----HADEV 487

  Fly   449 GYIFKLPATFKLD------KSRPEFTAIRRLVAMFVQFAATSDPNAPLTKSLVDWKP--VTRFGK 505
            .::|. .|..|.|      .:..|....|:::..:..||.|.:||.   ..|..|..  :|....
Human   488 RFVFG-GAFLKGDIVMFEGATEEEKLLSRKMMKYWATFARTGNPNG---NDLSLWPAYNLTEQYL 548

  Fly   506 RMVLNIS--EELKFIPQPEMPKLKFF 529
            ::.||:|  :.||      .|::.|:
Human   549 QLDLNMSLGQRLK------EPRVDFW 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	alpha/beta hydrolases	8..529	CDD:473884	155/544 (28%)
CES5A	NP_001177087.1	COesterase	58..568	CDD:395084	155/544 (28%)