DRSC/TRiP Functional Genomics Resources

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Protein Alignment alpha-Est4 and Nlgn2

DIOPT Version :9

Sequence 1:NP_524266.1 Gene:alpha-Est4 / 40906 FlyBaseID:FBgn0015572 Length:541 Species:Drosophila melanogaster
Sequence 2:NP_001351066.1 Gene:Nlgn2 / 216856 MGIID:2681835 Length:836 Species:Mus musculus


Alignment Length:586 Identity:173/586 - (29%)
Similarity:258/586 - (44%) Gaps:148/586 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 EDAPVVQTTHGKVRGILLKSLYDE---QFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRD---- 64
            |..|||.|.:|:|||: .:.|.:|   ....|.|:|||.||||..||:.|.....|.|:|:    
Mouse    39 ERFPVVNTAYGRVRGV-RRELNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTL 102

  Fly    65 ---CSKPLSKCLQVSTL----TKEVEG--------SEDCLYLNISVKTLNGDPM----------- 103
               |.:.|...|....|    |..:|.        ||||||||:.|.|.:| |:           
Mouse   103 PPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDG-PLTKKRDEATLNP 166

  Fly   104 -----------PVMVYIHGGAFKGG------DSSRRAWGPDYFMKENVVYISIGHRLGPLGFLSL 151
                       |||:::|||::..|      .|...|:|       ||:.:::.:|||.|||||.
Mouse   167 PDTDIRDSGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYG-------NVIVVTLNYRLGVLGFLST 224

  Fly   152 NDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITIFGHSSGSMTVQLLLASPQSEGLFHRA 216
            .|.  ...||.||.|.|.||||:..|.|:|.||||||||||..:|:..|.||:.|..|||||.:|
Mouse   225 GDQ--AAKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKA 287

  Fly   217 ILLAG---FSMELNRLPQMEYR--LAKHLGYEGDNVDSQVLEFLLKADPALIVSADFFTPLEKRQ 276
            |..:|   .|..:|..| ::|.  ||..:|.:.:: .::.:|.|.:.....:|..|.     :..
Mouse   288 IAQSGTAISSWSVNYQP-LKYTRLLAAKVGCDRED-STEAVECLRRKSSRELVDQDV-----QPA 345

  Fly   277 GHNMPFKPSIESYSTPNAVLLAEP-IDLQRTTWSNRIPIILGANSGEGM---------------S 325
            .:::.|.|.::....|:     :| |.:|:..:.| ..:::|.|.|||:               |
Mouse   346 RYHIAFGPVVDGDVVPD-----DPEILMQQGEFLN-YDMLIGVNQGEGLKFVEDSAESEDGVSAS 404

  Fly   326 IFSFVKMNPSWLKEFQCNPE--RVLPWTLR-------NRCDPGQRRQLGQALIHHFCEAHGHELT 381
            .|.|...|  ::......||  .||..|::       :| |.|:.|:                  
Mouse   405 AFDFTVSN--FVDNLYGYPEGKDVLRETIKFMYTDWADR-DNGEMRR------------------ 448

  Fly   382 VDHTNGLVELFT-HGFVHAMDRLIQSRLTYGQAPTYLYRFDFDSPDFNFYRIRFMGK-EQRGVGH 444
                ..|:.||| |.:|.......:....| |:|.|.|.|        ::..:..|: |.....|
Mouse   449 ----KTLLALFTDHQWVAPAVATAKLHADY-QSPVYFYTF--------YHHCQAEGRPEWADAAH 500

  Fly   445 VDELGYIFKLP---AT--FKLDKSRPEFTAIRRLVAMFVQFAATSDPNAPLTK--SLVDWKPVTR 502
            .|||.|:|.:|   ||  |..:.|:.:......::..:..||.|.|||.|:.:  ..:..|| .|
Mouse   501 GDELPYVFGVPMVGATDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKP-NR 564

  Fly   503 F 503
            |
Mouse   565 F 565

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-Est4NP_524266.1 Abhydrolase 7..529 CDD:304388 173/586 (30%)
Aes <104..>219 CDD:223730 56/120 (47%)
Nlgn2NP_001351066.1 COesterase 42..601 CDD:306613 172/583 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 623..661
Required for interaction with LHFPL4. /evidence=ECO:0000269|PubMed:28279354 679..699
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 711..735
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 791..836
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167832896
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1516
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.740

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