Protein Alignment alpha-Est4 and Nlgn2

DIOPT Version :10

• Sequence 1: NP_524266.1
• Gene: alpha-Est4 / 40906
• FlyBaseID: FBgn0015572
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_942562.2
• Gene: Nlgn2 / 216856
• MGIID: 2681835
• Length: 836
• Species: Mus musculus
• Alignment Length: 586
• Identity: 173/586 - (29%)
• Similarity: 258/586 - (44%)
• Gaps: 148/586 - (25%)

  Fly     7 EDAPVVQTTHGKVRGILLKSLYDE---QFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRD---- 64
            |..|||.|.:|:|||: .:.|.:|   ....|.|:|||.||||..||:.|.....|.|:|:
Mouse    39 ERFPVVNTAYGRVRGV-RRELNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTL 102

  Fly    65 ---CSKPLSKCLQVSTL----TKEVEG--------SEDCLYLNISVKTLNGDPM----------- 103
               |.:.|...|....|    |..:|.        ||||||||:.|.|.:| |:
Mouse   103 PPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDG-PLTKKRDEATLNP 166

  Fly   104 -----------PVMVYIHGGAFKGG------DSSRRAWGPDYFMKENVVYISIGHRLGPLGFLSL 151
                       |||:::|||::..|      .|...|:|       ||:.:::.:|||.|||||.
Mouse   167 PDTDIRDSGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYG-------NVIVVTLNYRLGVLGFLST 224

  Fly   152 NDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITIFGHSSGSMTVQLLLASPQSEGLFHRA 216
            .|.  ...||.||.|.|.||||:..|.|:|.||||||||||..:|:..|.||:.|..|||||.:|
Mouse   225 GDQ--AAKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKA 287

  Fly   217 ILLAG---FSMELNRLPQMEYR--LAKHLGYEGDNVDSQVLEFLLKADPALIVSADFFTPLEKRQ 276
            |..:|   .|..:|..| ::|.  ||..:|.:.:: .::.:|.|.:.....:|..|.     :..
Mouse   288 IAQSGTAISSWSVNYQP-LKYTRLLAAKVGCDRED-STEAVECLRRKSSRELVDQDV-----QPA 345

  Fly   277 GHNMPFKPSIESYSTPNAVLLAEP-IDLQRTTWSNRIPIILGANSGEGM---------------S 325
            .:::.|.|.::....|:     :| |.:|:..:.| ..:::|.|.|||:               |
Mouse   346 RYHIAFGPVVDGDVVPD-----DPEILMQQGEFLN-YDMLIGVNQGEGLKFVEDSAESEDGVSAS 404

  Fly   326 IFSFVKMNPSWLKEFQCNPE--RVLPWTLR-------NRCDPGQRRQLGQALIHHFCEAHGHELT 381
            .|.|...|  ::......||  .||..|::       :| |.|:.|:
Mouse   405 AFDFTVSN--FVDNLYGYPEGKDVLRETIKFMYTDWADR-DNGEMRR------------------ 448

  Fly   382 VDHTNGLVELFT-HGFVHAMDRLIQSRLTYGQAPTYLYRFDFDSPDFNFYRIRFMGK-EQRGVGH 444
                ..|:.||| |.:|.......:....| |:|.|.|.|        ::..:..|: |.....|
Mouse   449 ----KTLLALFTDHQWVAPAVATAKLHADY-QSPVYFYTF--------YHHCQAEGRPEWADAAH 500

  Fly   445 VDELGYIFKLP---AT--FKLDKSRPEFTAIRRLVAMFVQFAATSDPNAPLTK--SLVDWKPVTR 502
            .|||.|:|.:|   ||  |..:.|:.:......::..:..||.|.|||.|:.:  ..:..|| .|
Mouse   501 GDELPYVFGVPMVGATDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKP-NR 564

  Fly   503 F 503
            |
Mouse   565 F 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	alpha/beta hydrolases	8..529	CDD:473884	172/585 (29%)
Nlgn2	NP_942562.2	COesterase	42..601	CDD:395084	172/583 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	623..661
		Required for interaction with LHFPL4. /evidence=ECO:0000269|PubMed:28279354	679..699
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	711..735
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	791..836