Protein Alignment alpha-Est4 and Nlgn1

DIOPT Version :9

• Sequence 1: NP_524266.1
• Gene: alpha-Est4 / 40906
• FlyBaseID: FBgn0015572
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: XP_006535478.1
• Gene: Nlgn1 / 192167
• MGIID: 2179435
• Length: 863
• Species: Mus musculus
• Alignment Length: 661
• Identity: 178/661 - (26%)
• Similarity: 255/661 - (38%)
• Gaps: 203/661 - (30%)

  Fly     1 MSDDYNEDAPVVQTTHGKVRGILLKSLYDE---QFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGI 62
            :|...::..|:|.|..||:||| .|.|.:|   ....|.|:|||.||.|..||:.|....||..|
Mouse    44 LSQKLDDVDPLVTTNFGKIRGI-KKELNNEILGPVIQFLGVPYAAPPTGEHRFQPPEPPSPWSDI 107

  Fly    63 RDCSKPLSKCLQ----------------------VSTLTKEVEGSEDCLYLNISVKTL------- 98
            |:.::....|.|                      ||:..:  :.|||||||||.|.|.
Mouse   108 RNATQFAPVCPQNIIDGRLPEVMLPVWFTNNLDVVSSYVQ--DQSEDCLYLNIYVPTEDVKRISK 170

  Fly    99 --------------------------------------NGDPMPVMVYIHGGAFKGG-----DSS 120
                                                  :|.|.|||||||||::..|     |.|
Mouse   171 ECARKPGKKICRKGGPLTKKHTDDLGDNDGAEDEDIRDSGGPKPVMVYIHGGSYMEGTGNLYDGS 235

  Fly   121 RRA-WGPDYFMKENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGD 184
            ..| :|       ||:.|::.:|||.|||||..|.  ...||.||.|:|.||||...|...|.||
Mouse   236 VLASYG-------NVIVITVNYRLGVLGFLSTGDQ--AAKGNYGLLDLIQALRWTSENIGFFGGD 291

  Fly   185 PERITIFGHSSGSMTVQLLLASPQSE---------GLFHRAILLAGFSMELNRLPQMEYRLAKHL 240
            |.|||:||..:|...|.||..|..||         |||.|||..:|.::....:.....:.|:.|
Mouse   292 PLRITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYARIL 356

  Fly   241 GYE-GDNVDS--QVLEFLLKADPALIVSADFFTPLEKRQGHNMPFKPSIESYSTPNAVLLAEPID 302
            ..: |.||..  :::|.|.|.....:|..|.     :...:::.|.|.|:....|:     :|..
Mouse   357 ATKVGCNVSDTVELVECLQKKPYKELVDQDV-----QPARYHIAFGPVIDGDVIPD-----DPQI 411

  Fly   303 LQRTTWSNRIPIILGANSGEGM---------------SIFSFVKMNPSWLKEFQCNPE--RVLPW 350
            |..........|:||.|.|||:               |.|.|...|  ::......||  .||..
Mouse   412 LMEQGEFLNYDIMLGVNQGEGLKFVENIVDSDDGVSASDFDFAVSN--FVDNLYGYPEGKDVLRE 474

  Fly   351 TLR-------NRCDPGQRRQLGQALIHHFCEAHGHELTVDHTNGLVELFT-HGFVHAMDRLIQSR 407
            |::       :|.:|..||:.                       |:.||| |.:|..........
Mouse   475 TIKFMYTDWADRHNPETRRKT-----------------------LLALFTDHQWVAPAVATADLH 516

  Fly   408 LTYGQAPTYLYRFDFDSPDFNFYRIRFMGKEQ----RGVGHVDELGYIFKLP-----ATFKLDKS 463
            ..:| :|||.|.|        ::..:   .:|    ....|.||:.|:..:|     ..|..:.|
Mouse   517 SNFG-SPTYFYAF--------YHHCQ---TDQVPAWADAAHGDEVPYVLGIPMIGPTELFPCNFS 569

  Fly   464 RPEFTAIRRLVAMFVQFAATSDPNAPL---TKSL---------VDWKPVTRFGKRMVLNISEELK 516
            :.:......::..:..||.|.|||.|:   ||.:         |.|   ||:.::..|.:...||
Mouse   570 KNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAW---TRYSQKDQLYLHIGLK 631

  Fly   517 FIPQPEMPKLK 527
                   |::|
Mouse   632 -------PRVK 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	177/655 (27%)
		Aes	<104..>219	CDD:223730	59/129 (46%)
Nlgn1	XP_006535478.1	COesterase	53..646	CDD:365897	177/652 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832532
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740