Protein Alignment alpha-Est4 and cest-3

DIOPT Version :9

• Sequence 1: NP_524266.1
• Gene: alpha-Est4 / 40906
• FlyBaseID: FBgn0015572
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_510042.2
• Gene: cest-3 / 181385
• WormBaseID: WBGene00008451
• Length: 588
• Species: Caenorhabditis elegans
• Alignment Length: 558
• Identity: 135/558 - (24%)
• Similarity: 213/558 - (38%)
• Gaps: 141/558 - (25%)

  Fly    11 VVQTTHGKVRGILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLSKCLQV 75
            ::.||:||:.|   |::..:| :.|..:|:|.||||.|||..|....||..||:.::....|...
 Worm    23 IISTTYGKLEG---KTVNVDQ-HMFKNVPFAKPPLGKLRFSLPEWTNPWKNIRNATEYSPSCFSN 83

  Fly    76 STLTKE---VEGSEDCLYLNISVK--TLNGDPMPVMVYIHGGAFKGGDSS---RRAWGPDYFMKE 132
            |::..:   ...||||||||:...  .|.......:||.|||.. ..||:   ...:..:.::||
 Worm    84 SSMRTDSNFFPMSEDCLYLNVFTNEYCLKSKNCSTVVYYHGGGI-NMDSAVQFNDTFILERYVKE 147

  Fly   133 NVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITIFGHSSGS 197
            |||:|...:|||..|.|.....:| ||.|..:.|..||||:|....:||.|..:.|.:.|||:|:
 Worm   148 NVVFIIPAYRLGIFGLLYFGSNNL-VPQNLAIHDCELALRFIHQEISNFGGHKDDINLMGHSAGA 211

  Fly   198 MTVQLLLA-----SPQSEGLFHRAILLA---GFSM-ELNRLPQMEYRLAKHLGYEGDNV---DSQ 250
             .:.|:..     .|..: |.:|.|:|:   .:.| ||  |.:..|..|:.:|....||   |::
 Worm   212 -HISLIFGFSRHIDPDHK-LINRIIVLSPVPSYDMPEL--LIKNCYDFAERVGCYKRNVTARDTE 272

  Fly   251 VLEFLLKADPALIVSADFFTPLEKRQGHNM----PFKPSIES------YSTPNAVLLAEPIDLQR 305
            :::.|.|.|...::|.......::....|.    ||....||      |:....:|:...:|  .
 Worm   273 IVKCLRKKDARGLMSMQRLMENDRLYFWNFLAGEPFMYRDESIADFKEYAVKRDMLIGNTVD--E 335

  Fly   306 TTWSNRIPIILGANSGEGMSIFSFVKMNPSWLKEFQC--NPERVLPWTLRNRCDPGQRRQLGQAL 368
            ..|..                  ..|.||:....|..  ||..|
 Worm   336 VKWKR------------------LKKENPAIAGSFMDWENPYEV--------------------- 361

  Fly   369 IHHFCEAHGHELTVDH----TNGLVELFTHGFVHAMDRLIQSRLTYGQA------PTYLYRFDFD 423
                    .|:....|    .|...|.||.|       :..|..||.:|      ..||::
 Worm   362 --------AHKFNFYHDSAPVNSTYESFTQG-------IFVSTATYAEAQANAGGTVYLFQ---- 407

  Fly   424 SPDFNFYRIRFMGKEQRGVGHVDELGYIFKLPATFKLDKSRPEF----TAIRRLVAMFVQFAATS 484
                         ..|:...||.::.|..   .|.:.|....:.    |...:::..|.:|.:.|
 Worm   408 -------------SNQQPSSHVSDMQYFV---GTHREDYHTSDMDIMDTFYSKMIVNFTKFGSPS 456

  Fly   485 DPNAPLTKSLVDWKPVTRFGKRMVLNISEELKFIPQPE 522
            ....||..|.:::         ..|.::.|....|:.|
 Worm   457 PVWEPLVPSRMNY---------YALEVNTEKGIWPRME 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	135/558 (24%)
		Aes	<104..>219	CDD:223730	41/122 (34%)
cest-3	NP_510042.2	Abhydrolase	23..496	CDD:304388	135/558 (24%)
		Aes	<118..>254	CDD:223730	46/141 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157132
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740