Protein Alignment alpha-Est4 and cest-16

DIOPT Version :10

• Sequence 1: NP_524266.1
• Gene: alpha-Est4 / 40906
• FlyBaseID: FBgn0015572
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_741812.2
• Gene: cest-16 / 180905
• WormBaseID: WBGene00020330
• Length: 697
• Species: Caenorhabditis elegans
• Alignment Length: 634
• Identity: 159/634 - (25%)
• Similarity: 256/634 - (40%)
• Gaps: 139/634 - (21%)

  Fly     7 EDAPVVQTTHGKVRGILLKSLYD---EQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKP 68
            |.:..|....|.|||    ::|:   :....|.|:|||.||:|.||||.|.....||......:.
 Worm    21 EKSRSVWVEQGLVRG----NIYNIDGKHIQIFRGVPYAEPPIGELRFKPPVKKTRWHQELPAVEY 81

  Fly    69 LSKCLQVSTLTKEVE--------GSEDCLYLNI--------SVKTLNGDPMPVMVYIHGGAFKGG 117
            ...|||.....|..:        .||||||||:        ..||     .|::|:||||:|..|
 Worm    82 GPPCLQFMDFHKNDKFAKTNMDRQSEDCLYLNVFSPYDTDDESKT-----YPILVWIHGGSFLAG 141

  Fly   118 DSSRRAWGPDY------FMKENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRA 176
            .:..   |.|.      .:.:.:.::||.:|||||||::..:.| ::.||.|:.|:::||:||::
 Worm   142 SADT---GIDMEVIAANIVSKGIAFVSINYRLGPLGFMNYQNGD-KLEGNFGIWDMVMALQWIQS 202

  Fly   177 NAANFNGDPERITIFGHSSGSMTVQLLLASPQSEGLFHRAILLAGFSM---ELNRLPQMEYRLAK 238
            |...|||||.::|:.|.|:|.....||..||::.||.|:||:::|.||   .::|..|..|.:..
 Worm   203 NIKQFNGDPTKVTVMGESAGGAASSLLALSPKTSGLLHQAIIMSGSSMAGWAIHRHSQPAYSVDN 267

  Fly   239 HLGY-------EGDNVDSQVLEFLLKADPALIVSA-------------DFFTPLEK----RQGHN 279
            .:.|       ..|:....|.:.......::|.||             |..|.::|    |:..|
 Worm   268 LVAYFRCEKWINEDDTKEVVGDEYQHLTHSVIRSALCNYQNVKINCLTDDMTQMDKMNCLRKELN 332

  Fly   280 MPFKPSIESYSTP--NAVLLAE----------------PIDLQRTTWSNRIPIILGANSGE-GMS 325
                     :|:|  ...|.||                .:.|.|.  :.||||:.|....| |..
 Worm   333 ---------FSSPLFRKALAAELGVSKMVVDGDLVPSSGVSLVRN--NARIPIMTGVARKEWGHK 386

  Fly   326 IFSFVKMNP-SWLKEFQCNPE--RVLP----WTLRNRCDPGQRRQLGQALIHHFCEAHGHELTVD 383
            ...|..|:. ..||......:  |::.    .|...:......:.:..|.|..:.|...:|...|
 Worm   387 KAMFYNMHQRDGLKRSDVEEQVYRIIDNSFHETASEKLANSTVQLIANATIVRYLETPNNEFIAD 451

  Fly   384 HTNGLVELFTHG--FVHAMDRLIQSRLTYGQAPTYLYRFDF--DSPDFNFYR----------IRF 434
            ...|.::.....  ||...:|.:.:.:..| .|.|||.||:  .||.....|          :..
 Worm   452 QVVGALQKLESDIEFVAPCEREVAAYVDKG-VPVYLYSFDYVPKSPILESERKIYSLFGTKPVEM 515

  Fly   435 MGKEQ---------RGVGHVDELGYIFK--LPATFKLDK-SRPEFTAIRRLVAMFVQFAATSDPN 487
            ...|:         .|:.|    .:||.  ..:.|::.. ::.|.|..:.|..|...|....||:
 Worm   516 KRTEKSEILEKAAFHGLDH----AFIFSKGYSSNFEISPYTKREETMSKILCTMLTNFVKNGDPS 576

  Fly   488 APLTKSLVDWKPVTRFGKRMVLNISEELKFIP-QPEMPKLKFFDRLYEM 535
            .    :...| |:........:::...||.:. :...|..:|::...|:
 Worm   577 T----TRFSW-PIFSGNSSQYVSLDVPLKLLEGEIHFPDAQFWNTEAEL 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	alpha/beta hydrolases	8..529	CDD:473884	156/625 (25%)
cest-16	NP_741812.2	alpha/beta hydrolases	23..608	CDD:473884	155/618 (25%)