Protein Alignment alpha-Est4 and cest-26

DIOPT Version :10

• Sequence 1: NP_524266.1
• Gene: alpha-Est4 / 40906
• FlyBaseID: FBgn0015572
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_001368609.1
• Gene: cest-26 / 180715
• WormBaseID: WBGene00017478
• Length: 585
• Species: Caenorhabditis elegans
• Alignment Length: 550
• Identity: 156/550 - (28%)
• Similarity: 235/550 - (42%)
• Gaps: 81/550 - (14%)

  Fly    12 VQTTHGKVRGILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLSKCLQV- 75
            |:|.:|.|.|..:|...|.:...|.|||:|..|:|.||||.|...:.|.|::.|.:...:..|.
 Worm    44 VRTRNGLVEGFRIKIDDDREVDMFLGIPFAKAPVGDLRFKNPEHTEDWDGVKKCVRFGPRAPQAD 108

  Fly    76 ---STLTKEVEGSEDCLYLNISVKTLNGDPM-----PVMVYIHGGAF------KGGDSSRRAWGP 126
               ...|..|..||||||||:...|...:.:     |||||:|||.|      |.||...    .
 Worm   109 FFWERFTLGVGKSEDCLYLNVFSPTWKAEEVSNGLHPVMVYVHGGGFLIDSAVKYGDEGI----A 169

  Fly   127 DYFMKENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITIF 191
            .|..:..||.::|.:|||.|||.|..|.  ..|||.||.|:.:||:|:|.|...|.|||.::|:|
 Worm   170 KYLCRHGVVVVTIQYRLGLLGFFSTGDQ--VCPGNLGLWDMTMALQWVRDNVHAFGGDPRKVTVF 232

  Fly   192 GHSSGSMTVQLLLASPQSEGLFHRAILLAG------FSMELNRLPQMEYRLAKHLGY-------- 242
            |.|:|.::|.||..||.|..|||:.:.:||      .::..|||    ....:...|
 Worm   233 GQSAGGVSVDLLSLSPHSRDLFHQVVPMAGNGECEWSTVGKNRL----VNACREFAYRKCWDEKQ 293

  Fly   243 -EGDNVDSQVLEFLLKADPALIVSADFFTPLEKRQGHN-----MPFKPSIESYSTPNAVLLAEPI 301
             ..:|....:||||....     ..:|...|..|:|.:     :...|.|.  |.|:..|.....
 Worm   294 ARDENASESMLEFLRTRK-----EREFEKRLLTRKGVDVSKIGLDLAPVIG--SKPSDFLPKSIE 351

  Fly   302 DLQRTTWSNRIPIILGANSGEGMSIFSFVKMNPSWLKEFQCNPERVLPWTLRNRCDPGQRRQLGQ 366
            :|::.  :.:..|::|....||:   .|..:.||...|...:....|..|..|..|       .:
 Worm   352 ELRKE--APKKNIMVGTCEHEGL---LFASLGPSNFDEKGIDKLLALLITEENHED-------FE 404

  Fly   367 ALIHHFCEAHGHELTVDHTNGLVELFTHGFVHAMDRLIQSRLTYGQA--------PTYLYRFDFD 423
            ||.....:.:..:|:.|..:  .|:...|::.....|..:..||..|        ..::|.||:.
 Worm   405 ALREEAKKMYLKKLSDDEDD--KEVAARGYIQLYSDLFVNNGTYNYAEKMTKLGNKVFMYSFDYC 467

  Fly   424 SP-DFNFYRIRFMGKEQRGVGHVDELGYIFKLPATFKLDKSRPEFTAIRRLVAMFVQFAATSDPN 487
            :| .|....:|   ...|...|..||.|||.:...|....:..:...:..:..|:..||...:||
 Worm   468 NPRSFGILSLR---APFRAATHCTELAYIFGVSIVFNYRYNESDRAMLDLMTKMWTNFAKYGNPN 529

  Fly   488 APLTKSLV---DWKPVTRFGKRMVLNISEE 514
            .....|.|   .|:|.::......|.|:|:
 Worm   530 GQYEDSTVFDFKWEPTSKEEPTNFLAINEK 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	alpha/beta hydrolases	8..529	CDD:473884	156/549 (28%)
cest-26	NP_001368609.1	COesterase	40..575	CDD:395084	156/549 (28%)