Protein Alignment alpha-Est4 and cest-2.3

DIOPT Version :10

• Sequence 1: NP_524266.1
• Gene: alpha-Est4 / 40906
• FlyBaseID: FBgn0015572
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_506510.2
• Gene: cest-2.3 / 179918
• WormBaseID: WBGene00013873
• Length: 665
• Species: Caenorhabditis elegans
• Alignment Length: 571
• Identity: 137/571 - (23%)
• Similarity: 226/571 - (39%)
• Gaps: 108/571 - (18%)

  Fly    12 VQTTHGKVRGILLKSLY----DEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCS--KPLS 70
            :|.:.|.:.|.:|.:.|    ::....|.||||..||:|.|||::|..||.|.|:.:..  ||..
 Worm    20 IQLSTGTIEGKILNATYSPFGNQTATVFLGIPYVEPPIGELRFRKPRLLKSWEGVLETKDYKPAC 84

  Fly    71 KCLQVSTLTKEVEG--SEDCLYLNISVK--TLNGDPMPVMVYIHGGAFKGGDSSRRAWGPDYFMK 131
            ......|......|  ||||||.|:...  .|......||:.:|||.......|  |:.|:.|:.
 Worm    85 MSYWRKTFKNGFVGEISEDCLYANVFTNQYCLQNKNCSVMIVVHGGRLVCESGS--AFKPEIFIN 147

  Fly   132 ------ENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITI 190
                  .|:|.::..:|||..||...|....:.  |..:.|::.|::|:|.....|.|:.:|||:
 Worm   148 NFVGQDRNIVVVTFNYRLGVFGFGVFNGETGDT--NVAMYDMLEAVKWVRKEIDQFGGNKDRITM 210

  Fly   191 FGHSSGSMTVQLLLASPQSEGLFHRAILLAGFSMELNRLPQMEYRLAKHLGYEGDNVDSQVLEFL 255
            .|||:|:..:....:|..|:||.|:.|:::.        |..:  ::|...::|..:.:|
 Worm   211 AGHSAGAGLIVDFTSSTLSKGLLHQQIVMSA--------PLQD--ISKSANFKGMTIVAQ----- 260

  Fly   256 LKADPALIVSADFFTPLEKRQGHNMPFKPSIESYSTPNAVLLAEPIDLQRTTWSNRIPIILGANS 320
               :...|.....|..|.|.|.:....  .:::.|..:  ||...:.:|:.:     ....|:..
 Worm   261 ---NVGCIPKEYGFRKLSKTQINKTYL--CLQNKSAQD--LLHAQLSMQQNS-----TFYFGSPR 313

  Fly   321 GEGMSIFSFVKMNPSWLKEFQCNPERVLP---------WTLRNR---CDPGQRRQLGQALIHHFC 373
            .:|    .|:...|..|..|    ..:.|         ..||:.   .||...| :.:.|:.:.|
 Worm   314 VDG----DFITDYPDNLFNF----NTIYPINTFIGTTTGELRDSLYITDPKNDR-IKEQLLKNMC 369

  Fly   374 EAHGHELTVD-----------HTNGLVELFTHGFVHAMDRLIQSRLTYGQA--PTYLYRFDFDSP 425
            |..|:||...           :.||....|....:......|:....:.:|  ..::|.:|:...
 Worm   370 EHVGYELFEKPEEFTKKCGNYYKNGTDAQFLSDDMEFYSGAIKVANAHKRANSKVFMYSYDYKGA 434

  Fly   426 DFNFYRIRFMGKEQRGVGHVDELGYIFKLPATFKLDKSRPEFTA----IRRLVA-MFVQFAATSD 485
            ...|::.    .|.....|.::|.|.|        ..||..|.|    |.|:.: |...|....|
 Worm   435 GTAFHKY----LEAPSPHHSEDLIYTF--------GTSRGPFVAKDYVIERIYSGMLANFINFED 487

  Fly   486 PNAPLTKSLVDWKPVTRFGKRMVLNISEELKFIPQPEMPKLKFFDRLYEMA 536
            |:...|:   .|:..|: .||....|..:..|    .||.:|  |..|..|
 Worm   488 PSPSKTQ---QWRQYTQ-EKREYFLIDFDKNF----TMPGMK--DHYYTRA 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	alpha/beta hydrolases	8..529	CDD:473884	134/562 (24%)
cest-2.3	NP_506510.2	alpha/beta hydrolases	17..532	CDD:473884	137/571 (24%)