Protein Alignment alpha-Est4 and cest-2.2

DIOPT Version :10

• Sequence 1: NP_524266.1
• Gene: alpha-Est4 / 40906
• FlyBaseID: FBgn0015572
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_001256567.1
• Gene: cest-2.2 / 179917
• WormBaseID: WBGene00013874
• Length: 672
• Species: Caenorhabditis elegans
• Alignment Length: 574
• Identity: 142/574 - (24%)
• Similarity: 228/574 - (39%)
• Gaps: 124/574 - (21%)

  Fly    17 GKVRGILLKSLY----DEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLSKCL--QV 75
            |.:.|..|.:.|    ::....|.|:||..||:|.|||::|...|||.|:.:..:..:.|:  |.
 Worm    27 GTIEGRTLTASYSPLGNQTGIVFFGVPYVEPPVGNLRFRKPRPPKPWDGVLEAKEYKAACMSDQK 91

  Fly    76 STLTKEVEG--SEDCLYLNISVK--TLNGDPMPVMVYIHGGAFKGGDSSRRAWGPDYFMK----- 131
            .|....|.|  ||||||.|:...  .|......||:.||||.|.  ..|..|:.|:..:.
 Worm    92 KTYKNGVGGPVSEDCLYANVFTNQYCLEHKNCSVMLTIHGGRFV--IESASAYDPEIIINNFVGQ 154

  Fly   132 -ENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITIFGHSS 195
             .|:|.::..:|||..|...||..:.:.  |.||.|::..:||.|....||.||.:|||:.|||:
 Worm   155 GRNIVVVTFNYRLGLFGLGMLNGDNQDT--NFGLYDILEVVRWTRKEIKNFGGDKDRITMQGHSA 217

  Fly   196 GSMTVQLLLASPQSEGLFHRAILLAGFSMELNRLPQMEYR--LAKHLGYEGD--------NVDSQ 250
            |::.......||.|:||.|:.|:::.....|::...::..  :|:.:|...|        ||:.:
 Worm   218 GAVFTAAFSTSPLSKGLIHQQIIMSASMSNLSKKSNVKELTVVARIVGCLPDEHGFPKLSNVEVE 282

  Fly   251 VLEFLLKADPA-LIVSADFF----TPLEKRQGHNMPFKPSIESYSTPNAVLLAEPIDLQRTTWSN 310
            .....|::..| .|:.|..:    |.....|||            ......:..|.:|..|....
 Worm   283 KAYTCLRSKSAQQILDAQLYMLRNTTYYIGQGH------------IDGIYQVDYPDNLYATNSIY 335

  Fly   311 RIPIILGANSGEGMSIFSFVKMNPSWLKEFQCNPERVLPWTLRNRCDPGQRRQLGQALIHHFCEA 375
            .|..::|..:.|.|.            ..:..:|:           :.|::    :.|:.:.||.
 Worm   336 PINTMIGTTTAELMD------------SRYIVDPK-----------NTGKK----EILLQNLCEH 373

  Fly   376 HGHELTVD-----------HTNGL--------VELFTHGFVHAMDRLIQSRLTYGQAPT--YLYR 419
            .|:||..:           :.||.        :| |.:|       .||....:....|  ::|.
 Worm   374 IGYELYKEPEEFSQKCRNFYKNGEDAKSLGDDME-FYYG-------AIQLANVHSSKDTNVFVYS 430

  Fly   420 FDFDSPDFNFYRIRFMGKEQRGVG--HVDELGYIFKLPATFKLDKSRPEFTAIRRLVAMFVQFAA 482
            ||:.... |.|:     |..:.:.  |.::..|.|   .|.:.:.|..::........||..|..
 Worm   431 FDYKEAG-NAYK-----KYDKSLSPKHGEDFAYAF---GTNRGNFSTKDYVIEYIYSGMFADFVN 486

  Fly   483 TSDPNAPLTKSLVDWKPVTRFGKRMVLNISEELKFIPQPEMPKLKFFDRLYEMA 536
            ..|| :||...  :|...|. .||....|..:..|    .||.:|  |..|..|
 Worm   487 FGDP-SPLEDQ--EWAQYTP-EKREYFLIDFDKNF----TMPGMK--DHYYPKA 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	alpha/beta hydrolases	8..529	CDD:473884	139/565 (25%)
cest-2.2	NP_001256567.1	alpha/beta hydrolases	25..534	CDD:473884	142/574 (25%)