DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est4 and cest-2.1

DIOPT Version :9

Sequence 1:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_506508.2	Gene:	cest-2.1 / 179916	WormBaseID:	WBGene00013875	Length:	675	Species:	Caenorhabditis elegans

Alignment Length:	588	Identity:	136/588 - (23%)
Similarity:	223/588 - (37%)	Gaps:	150/588 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VQTTHGKVRGILLKSLY----DEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLSKC 72
            ||.:.|.:.|.:|.|.|    :.....|.|||:..||.|.|||::|....||.||.:..:....|
Worm    21 VQLSTGTIEGKILTSTYSPLGNHTGIGFLGIPFVEPPAGNLRFRKPRPPIPWDGILETKEYKPAC 85

  Fly    73 LQ--VSTLTKEVEG--SEDCLYLNI-----SVKTLNGDPMPVMVYIHGGAFKGGDSSRRAWGPDY 128
            :.  ..|....|.|  ||||||.|:     .:|..|   ..||:.:|||...  ..|..|:.|:.
Worm    86 MSDAKKTYKNGVGGPISEDCLYANVFTNQYCMKRKN---CSVMIVVHGGRIL--TESASAFNPEI 145

  Fly   129 FMK------ENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPER 187
            .:.      .|:|.::..:|||..||..||..  :...|.|:.|::.|::|.|....||.|:.::
Worm   146 LVNNFVGQGRNIVVVTFNYRLGTFGFGVLNGE--KGDSNVGMFDMLEAVKWTRKEVHNFGGNKDK 208

  Fly   188 ITIFGHSSGSMTVQLLLASPQSEGLFHRAILLAGFSMELNRLPQMEYRLAKHLGYEGDNVDSQVL 252
            :|:.|||:|...|....:||.|:|:.::.|:::|          ..|::.|...::|
Worm   209 LTMVGHSAGGSLVGAFTSSPLSKGMLNQQIIMSG----------ALYQMGKLANFKG-------- 255

  Fly   253 EFLLKADPALIVSADFFTPLEKRQGHNMPFKPSI------------ESYSTPNAVLLAEPID--- 302
                            .|.:.::.|    ..|.:            ::||....:...|.:|
Worm   256 ----------------MTAMAQKAG----CLPEVFGFRKLSQVRIDKTYSCLRNISAQEVLDAQL 300

  Fly   303 --LQRTTWSNRIPIILGANSGEGMSIFSFVKMNPSWLKEFQCNP-ERVLPWTLRNRCDPGQRRQL 364
              ||.||:...:|.|    .||.:..:|     ...|.....:| ..::..|.....||.....|
Worm   301 WVLQNTTYYISVPHI----DGEFLLNYS-----DEILASGTIHPINSMIGTTTAELRDPIYINDL 356

  Fly   365 GQA-----LIHHFCEAHGHELTVD-----------HTNGLVELFTHGFVHAMDRLIQSRLTYGQA 413
            ..|     |:.:.||..|:||..:           :.||....|....:...|..|:....:...
Worm   357 KNADKKEELLKNLCEHIGYELYTEPEEFSRKCQKFYGNGDDAQFLADDMEFYDGSIKVANAHASK 421

  Fly   414 PTYLYRFDFD----SPDFNFYRIRFMGKEQRGVGHVDELGYIFKLPATFKLDKSRPEFT----AI 470
            .|.::.:.:|    .|.|..|      .:.....|.::|.|:|        ..||..||    .|
Worm   422 NTKVFMYSYDYKDAGPAFKKY------AQAPPPHHSEDLIYVF--------GTSRGNFTEKDYVI 472

  Fly   471 RRLVA-MFVQFAATSDPNAPLTKSLVDWKPVTRFGKRMVLNISEELKFIPQPEMPKLKFFDRLYE 534
            .::.: ||..|....:|:....:.   ||                 ::.|:.....|..||:.:.
Worm   473 EQIYSGMFADFVNFGNPSPSKEQK---WK-----------------EYSPEKREYFLIDFDKNFT 517

  Fly   535 MAG 537
            |.|
Worm   518 MPG 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	132/578 (23%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	37/120 (31%)
cest-2.1	NP_506508.2	COesterase	21..533	CDD:365897	136/588 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157078
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740