Protein Alignment alpha-Est4 and cest-1.2

DIOPT Version :10

• Sequence 1: NP_524266.1
• Gene: alpha-Est4 / 40906
• FlyBaseID: FBgn0015572
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_506504.2
• Gene: cest-1.2 / 179914
• WormBaseID: WBGene00011364
• Length: 676
• Species: Caenorhabditis elegans
• Alignment Length: 601
• Identity: 143/601 - (23%)
• Similarity: 220/601 - (36%)
• Gaps: 165/601 - (27%)

  Fly    12 VQTTHGKVRGILLKSLY----DEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLSKC 72
            ||.:.|.:.|..|.|.|    ::...||.||||..||:|.|||::|...|.|.|:.:..|....|
 Worm    21 VQLSTGIIEGKQLNSTYSPFGNQSAIAFLGIPYVEPPIGDLRFRKPRPQKTWSGVLETKKFKPAC 85

  Fly    73 LQVSTLTKEVEG-----SEDCLYLNISVK--TLNGDPMPVMVYIHGGA----------------- 113
            :..||.|.:..|     ||||||||:...  .|......|::.:|||.
 Worm    86 MSNSTKTYKNGGIGGPISEDCLYLNVLTNQYCLENKNCSVVIIVHGGGYLFESAATFNHEILVNN 150

  Fly   114 FKGGDSSRRAWGPDYFMKENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANA 178
            |.|.|             .|:|.::|.:|||..||..||  ..|...|.|:.|.:.|::|:|...
 Worm   151 FVGQD-------------RNIVVVTINYRLGIFGFGHLN--GFEGDKNVGIFDTLEAVKWVRREI 200

  Fly   179 ANFNGDPERITIFGHSSGSMTVQLLLASPQSEGLFHRAILLAGFSMELNR------LPQMEYRLA 237
            ..|.|:.:|||:.|||:|:..|.....||.::||.|:.|:::|....:::      :..|..|:.
 Worm   201 KQFGGNKDRITLAGHSAGAGVVAAFTISPLTKGLIHQQIVMSGPMTNMSKKSNFKGMTAMAERVG 265

  Fly   238 KHLGYEGDNVDSQVLEFLLKADPALIVSADFFTPLEKRQGHN-MPFKPSIESYSTPNAVLLAEPI 301
            .|                                 .|:.|.| :|.....:.||........|.:
 Worm   266 CH---------------------------------SKKYGFNKLPEHEVEQVYSCLRKKPAQELL 297

  Fly   302 D-----LQRTTWSNRIPIILGA-------NSGEGMSIFSFVKMNPSWLKEFQCNPERVLPWTLRN 354
            |     ||.:|:....|.:.|.       |.....||||.               ..:|..|.|.
 Worm   298 DAQLWLLQNSTFYFGAPPVDGEFITDYPDNLYSEKSIFSI---------------NTLLGTTTRE 347

  Fly   355 RCDPG-------QRRQLGQALIHHFCEAHGHELTVD-----------HTNGL--------VELFT 393
            ..|.|       .:.:..:..:.:.|:..|.|:..:           :.||.        :|.:|
 Worm   348 LQDTGYISNSNYSKFETKETFLKNLCDQIGIEIYKESEDFSSKCQKWYINGSDSKSLSDDMEFYT 412

  Fly   394 HGFVHAMDRLIQSRLTYGQAPTYLYRFDFDSPDFNFYRIRFMGKEQRGVGHVDELGYIFKLPATF 458
            .....|.....:.:..|    .|.|.:....|.|..|      .:.:...|.::|.|      ||
 Worm   413 QAINLADAHARKGKKVY----MYSYAYSGAGPAFKKY------MKVKSPHHSEDLIY------TF 461

  Fly   459 KLDKS--RPEFTAIRRLVA-MFVQFAATSDPNAPLTKSLVDWKPVTRFGKRMVLNISEELKFIPQ 520
            ...:.  .|:...|..:.: ||..|....|| :|.|..  .|...|:..|...|     :.|...
 Worm   462 GTHRGVFAPKDYVIEYIYSGMFADFINFEDP-SPSTDQ--PWLQYTKENKEYFL-----VDFDQN 518

  Fly   521 PEMPKLK--FFDRLYE 534
            ..||.:|  ::.:.||
 Worm   519 LTMPGMKKNYYAKAYE 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	alpha/beta hydrolases	8..529	CDD:473884	141/594 (24%)
cest-1.2	NP_506504.2	COesterase	18..536	CDD:395084	143/601 (24%)