DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est4 and cest-17

DIOPT Version :9

Sequence 1:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_505114.1	Gene:	cest-17 / 179198	WormBaseID:	WBGene00019477	Length:	571	Species:	Caenorhabditis elegans

Alignment Length:	565	Identity:	153/565 - (27%)
Similarity:	242/565 - (42%)	Gaps:	143/565 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PVVQTTHGKVRGILLKS-LYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPW-HGIRDCSKPLSKC 72
            |.|.|.:|.:.|...|| :...:::.|.||.|..||....||::|..::.| |...|.:...:.|
Worm    22 PKVTTPYGPIVGFEHKSTVTGSKYHVFLGIRYGNPPDHIYRFQKPEPVEKWPHINHDATHFRASC 86

  Fly    73 LQV--STLTKEVEGSEDCLYLNI-SVKTLNGDPMPVMVYIHGGAFKGGDSSRRAW--GPDYFMKE 132
            :..  |.|.::|..|||||:||| :........:||:|:||||.|:.||:|...:  ..|.|:.:
Worm    87 IPSLRSELEEQVNYSEDCLFLNIVTPPDAKEKKLPVLVFIHGGGFQFGDTSMIGYQKAADNFVSK 151

  Fly   133 NVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITIFGHSSGS 197
            :::::||.:|||||||.:..|.  |:|||.||.|..|||:::.....:|.|||:|||:.|||:|:
Worm   152 DIIFVSIQYRLGPLGFFTTGDS--EIPGNMGLWDQTLALQFLHEVLPDFGGDPDRITLAGHSAGA 214

  Fly   198 MTVQLLLASPQSEGLFHRAILLAG--FS-MELNR-LPQMEYRLAKHLGYE-------GDNVDSQV 251
            .:|..||.||.|:.||.:||.|:|  || ..|:| :.....:|||..|..       .|.::.:.
Worm   215 ASVSALLYSPHSDHLFSQAIQLSGSIFSESNLDRNVVDDSRKLAKAAGCPQEDSKELRDCIEIRT 279

  Fly   252 LEFLLKADPAL--------------IVSADFFTPLEKRQGHNMPFK------PSIES-YSTPNAV 295
            ::.||.|..::              ....|||....::.....|.|      .|:|| .|....|
Worm   280 VDELLDAMESIGELLPGPRTKKFHPYFDKDFFPYDIEKMSRKAPKKRTMQGLVSLESGLSVLYPV 344

  Fly   296 LLAEPIDLQRTTWSNRIPIILGANSGEGMSIFSFVKMNPSWLKEFQCNPERVLPWTLRNRCDPGQ 360
            .||:.:.:.:.:||          :....::..|::...:..:||.....|.
Worm   345 KLAKLLGVPKESWS----------TYSKDNLVDFIRSQVAVEQEFGTASARF------------- 386

  Fly   361 RRQLGQALIHHFCEAHGHELTVDHTNGLVE-------------LFTHGFVHAMDRL--------- 403
                                     :||||             .:.:.|.:.:..|
Worm   387 -------------------------SGLVEEFYLSGPMTGNSSFYLNAFANLLSDLQYNIPTLHE 426

  Fly   404 IQSRLTYGQAPTYLYRFDFDS-----PDFNFYRIRFMGKEQRGVGHVDELGYIFK------LPAT 457
            ::.:|.:|. .||||..|:||     |....          :|..|..||.|:|.      :|..
Worm   427 VELKLQHGW-DTYLYIIDYDSETTKDPTHPI----------KGPFHASELRYLFNFNGMDTIPFN 480

  Fly   458 FKLDKSRPEFTAIRRLVAMFVQFAATSDPNAPLTKSLVDWKPVTR 502
            .| ||....:     .|...|.|..|..|:   ||:|: |..|::
Worm   481 DK-DKKFENY-----FVNAIVNFINTGTPS---TKALL-WPAVSK 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	153/565 (27%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	54/116 (47%)
cest-17	NP_505114.1	COesterase	20..542	CDD:278561	153/565 (27%)
cest-17	NP_505114.1	Aes	<109..>225	CDD:223730	49/117 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28578
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.830