Protein Alignment alpha-Est4 and cest-34

DIOPT Version :9

• Sequence 1: NP_524266.1
• Gene: alpha-Est4 / 40906
• FlyBaseID: FBgn0015572
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_001360105.1
• Gene: cest-34 / 179057
• WormBaseID: WBGene00019652
• Length: 550
• Species: Caenorhabditis elegans
• Alignment Length: 535
• Identity: 145/535 - (27%)
• Similarity: 225/535 - (42%)
• Gaps: 117/535 - (21%)

  Fly    11 VVQTTHGKVRGILLKSLY---DEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLSKC 72
            |:.|:.|.|.|    :||   |::.:.:.|:|||.||.|.:||.:|.....|...|||:|...:|
 Worm    16 VLNTSCGPVLG----NLYRHGDKEVHGYLGMPYAKPPTGEMRFAKPVPADDWTETRDCTKYGPRC 76

  Fly    73 -----------------------LQVSTLTKEVEGSEDCLYLNISVKTLNGDPMPVMVYIHGGAF 114
                                   |.|:......|.||   |.|         ..|||||:|||.|
 Worm    77 PPSGQGLEKGMFVNPDEPDEANGLSVNVFVPGWESSE---YKN---------ARPVMVYVHGGGF 129

  Fly   115 KGGDSSRRAWGPDYFMK-----ENVVYISIGHRLGPLGFLSLNDPDLEV-PGNAGLKDVILALRW 173
            :  .||.|.: .||.:.     ::|:.:::.:|||.|||.:..|   || |||.||.|..|||:|
 Worm   130 E--ISSSREF-CDYSISSTLPMKDVILVTMNYRLGILGFFTTGD---EVCPGNFGLWDQTLALQW 188

  Fly   174 IRANAANFNGDPERITIFGHSSGSMTVQLLLASPQSEGLFHRAILLAG-----FSMEL--NRLPQ 231
            ::.:.|:|.|||..:|:||.|:|...|.||..||.|..||.:.:.::|     |:|..  |....
 Worm   189 VQKHIASFGGDPNNVTLFGQSAGGACVDLLTLSPHSRDLFQKVVPMSGSAMCEFAMRTAENEAHV 253

  Fly   232 MEYRLAKHLGYEGDNVDSQVLEFLLKADPALIVSADFFTPLEKRQGHNMPFKPSIESYSTPNAVL 296
            .:..||: ||:.|.. ..:.|||:.......|.....:|   .:|...|...|:.:....|
 Worm   254 FDDILAR-LGFTGSG-SKERLEFMRSLPCDKITGKTGYT---YKQSGFMSLCPNYDGDFFP---- 309

  Fly   297 LAEPIDLQRTTWSNRIPIILGANSGEGMSIFSFVKMNPSWLKEFQCNPERVLPWTLRNRCD---- 357
              :|:|..|...|.|| ::.|....||: :|:|.:..|  .|::..        .||.:.:
 Worm   310 --KPLDELRKDASKRI-LMTGIVGNEGL-LFAFDRNTP--YKDYTD--------LLRLKIEEDYK 360

  Fly   358 -------PGQRRQLGQALIHHFCEAHGHELTVDHTNGLVELFTHGFVHAMDRLIQSRLTYGQAPT 415
                   .|.|:::.:....:..|.....:.......:.:...|..|.|   ..|:...:|. ..
 Worm   361 EDVVDDVEGIRKEIFEYYTKNISEGDEEAIMRKAAEFVGDSIFHTGVRA---TAQNAAEHGD-EV 421

  Fly   416 YLYRFDFDSPDFNFYRIRFMGKEQRGVG--------HVDELGYIFKLPATFKLDKSRPEFTAIRR 472
            :||.||:.:|| .|..::         |        |..||.|:|......|.:.:..|...:.:
 Worm   422 WLYNFDYCNPD-GFAPLK---------GYLPYIEPTHGMELRYLFGDGIISKFEPTEEELKMLDK 476

  Fly   473 LVAMFVQFAATSDPN 487
            ...||..||...:||
 Worm   477 FTTMFANFAKYGNPN 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	145/535 (27%)
		Aes	<104..>219	CDD:223730	52/120 (43%)
cest-34	NP_001360105.1	COesterase	15..530	CDD:365897	145/535 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28578
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm14726
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.820