Protein Alignment alpha-Est4 and cest-33

DIOPT Version :10

• Sequence 1: NP_524266.1
• Gene: alpha-Est4 / 40906
• FlyBaseID: FBgn0015572
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_504621.1
• Gene: cest-33 / 179020
• WormBaseID: WBGene00017431
• Length: 554
• Species: Caenorhabditis elegans
• Alignment Length: 592
• Identity: 157/592 - (26%)
• Similarity: 247/592 - (41%)
• Gaps: 132/592 - (22%)

  Fly     1 MSDDYNEDAPVVQTTHGKVRGILLKSLYDEQFY-AFDGIPYAVPPLGTLRFKEPHDLKPWHGIRD 64
            ::.:.|.:|  ::.:.|.|||.:.|  :|:... .:.|||||.||:|.||||:|..:..|..|:|
 Worm     8 LTPEQNVEA--LKASCGPVRGNIYK--HDDVIVDGYLGIPYAKPPVGELRFKKPVTVDVWTEIKD 68

  Fly    65 CSKPLSKCLQVS---------TLTKEVEGSEDCLYLNI------SVKTLNGDPMPVMVYIHGGAF 114
            |.|....|:|..         |.|.|..|   ||.||:      |.:..||  .|||||||||.:
 Worm    69 CYKYGPACVQTGGFEQIAGPRTPTPEEAG---CLTLNVFTPRNASSEFKNG--RPVMVYIHGGGY 128

  Fly   115 KGGDSSRRAWGPDY--------FMKENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILAL 171
            :...||      |:        ...::||.:||.:|||..|||:..|.  ..|||.||.|..|||
 Worm   129 ELCASS------DFCAYSLSGTLPLKDVVVVSINYRLGVFGFLTTGDN--VCPGNFGLWDQTLAL 185

  Fly   172 RWIRANAANFNGDPERITIFGHSSGSMTVQLLLASPQSEGLFHRAILLAG-----FSMELNRLPQ 231
            :|::.:.::|.|||..:|:||.|:|..:..||..||.|..||.|.|.::|     |::..:....
 Worm   186 KWVQKHISSFGGDPNCVTVFGQSAGGASTDLLSLSPHSRDLFQRFIPISGTAHCDFAIRASENQA 250

  Fly   232 MEYR-LAKHLGYEGDNVDSQVLEFLLKADPALIVSADFFTPLEKRQGHNMPFKPSIESYST--PN 293
            ..:| .|:..|:.|.: .|.:.::..:..|         ..|...:|    :|.||..:.|  ||
 Worm   251 KIFREFAEFHGFSGRD-SSALFKWYQEQSP---------ETLSNVKG----YKKSISGFLTFIPN 301

  Fly   294 --AVLLAEPIDLQRTTWSNRIPIILGANSGEGMSIFSFVKMNPSWL---------------KEFQ 341
              .....:|:|..|.. :.:..::.|....||:.:.|   |||::.               |:..
 Worm   302 LDGDFFPKPLDELRKE-APKKQMMTGVTEYEGLMLAS---MNPAFSPADVGLTLMPQGIYGKDVV 362

  Fly   342 CNPERVLPWTLRNRCDPGQRRQLGQALIHHFCEAHGHELTVDHTNGLVELFTHGFVHAMDRLIQS 406
            .||:.:.. ....:...|..:....|:....|||.|.           |.|..|.:.|    .::
 Worm   363 SNPDEIQK-IFYEKYVEGVDKSDELAMRKKLCEALGD-----------EFFNVGVIQA----AKN 411

  Fly   407 RLTYGQAPTYLYRFDFDSPD-FNFY--RIRFMGKEQRGVGHVDELGYIFKLPATFKLDKSRPEFT 468
            ...:|. ..|.|.|::.:|| |..:  .:.|     :...|..||.|:.......|.:.:..:..
 Worm   412 AAKHGN-EVYFYTFEYVNPDSFGMWDGMMPF-----KAAVHCTELRYLLGEGVYSKFEPTEEDRK 470

  Fly   469 AIRRLVAMFVQFAATSDPNAPLTKSLVDWKPVTRFGKRMVLNISEELKFIPQPE------MPKLK 527
            .:.....:|..||...:||                ||.....|.|:.. :.:||      .||.:
 Worm   471 VMETTTTLFSNFAKYGNPN----------------GKGATAEIWEKYS-LNRPERHYRISYPKCE 518

  Fly   528 FFDRLYE 534
            ..|..:|
 Worm   519 MRDVYHE 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	alpha/beta hydrolases	8..529	CDD:473884	154/578 (27%)
cest-33	NP_504621.1	Esterase_lipase	16..521	CDD:238191	154/578 (27%)