DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est4 and cest-24

DIOPT Version :9

Sequence 1:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_504613.1	Gene:	cest-24 / 179017	WormBaseID:	WBGene00020891	Length:	658	Species:	Caenorhabditis elegans

Alignment Length:	570	Identity:	163/570 - (28%)
Similarity:	245/570 - (42%)	Gaps:	108/570 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 NEDAPVVQTTHGKVRGILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSK--- 67
            :|:| :|:...|.:.|..:|:...:....|.|||||.||:|.|||::|...|.|.|||.|:|
Worm    93 SENA-IVRVQQGLLEGFRVKTAKGDLCDVFHGIPYAEPPVGELRFQKPQPPKAWEGIRKCNKYPN 156

  Fly    68 -------PLSKCLQVSTLTKEVEGSEDCLYLNISVKTLNGD-PMPVMVYIHGGAFKGGDSSRRAW 124
                   |..|.|      .....||||||||:....:..| ..||:.|||||.:. .||:.|..
Worm   157 RSIHKEMPWDKAL------PSANQSEDCLYLNVFAPKIREDKKYPVLFYIHGGGYV-MDSAERYT 214

  Fly   125 GPD---YFMKENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPE 186
            ..:   ..:...::.::..:|||.|||||..| |: .|||.||.|::.|:||:.||.::|.||||
Worm   215 AKNICKLLVSREIIVVTFHYRLGFLGFLSTGD-DV-CPGNYGLFDMLEAMRWVHANISSFGGDPE 277

  Fly   187 RITIFGHSSGSMTVQLLLASPQSEGLFHRAILLAGFS----MELNRLPQMEY--RLAKHLGYEGD 245
            .||:.|.|:|:....||..||.::|||.|.|::.|.|    ...:.....||  :.||.||::..
Worm   278 NITLSGQSAGAAAADLLSFSPLTKGLFKRKIVMGGNSYCHWATTSNHDIREYCKKWAKRLGWKPQ 342

  Fly   246 NVDSQVLEFLLKADPALIVSADFFTPL-EKRQGHNMPFKPSI-ESYSTPNA-VLLAE--PIDLQ- 304
                  |.:..|.:.::.: .:||..| ..:.|..|.|..:| :....|.| |:..|  |.||:
Worm   343 ------LNYANKREESVDI-FNFFNGLPTSKLGMTMFFSNTIFKECQLPLAPVIDGEILPHDLKV 400

  Fly   305 -RTTWSNRIPIILGANSGEGMSIFSFVKMNPSWLKE------------------FQCNPERVLPW 350
             |.| ...:|.::|....|.: :|..:.:.....||                  .:...|:|...
Worm   401 LRET-QEHVPSLVGGGEYEAL-LFCAIGLLRGTEKEINSAIDVLSRKNRLSRSKIEAMTEKVYGD 463

  Fly   351 TLRNRCDPGQRRQLGQALIHHFCEAHG-HELTVDHTNGLVELFTHGFVHAMDRLIQSRLTYGQAP 414
            :...|.|...|:.....||......:| :....|.....||.:.:.|.|      ||:..:|...
Worm   464 SPALRADSKARKMFFVQLISDIFANYGNYRFMRDCQQRGVECYGYSFDH------QSKQMWGWLQ 522

  Fly   415 TYLYRFDFDSPDFNFYRIRFMGKEQRGVGHVDELGYIF-----KLPATF-KLDKSRPEFTAIRRL 473
                           :.:.|.|..     |..||.|:|     ..|... |.||.....||  ..
Worm   523 ---------------HVVPFTGGT-----HTSELSYLFDCNYMSAPLGMNKTDKVVSGMTA--DY 565

  Fly   474 VAMFVQFAATSDPNAPLTKSLVDWKPVTRFGKRMVLNISEELKFIPQPEM 523
            ...||:|...:.||:.|.|    |:.::...:.|.|     :...|:|||
Worm   566 FTNFVKFGTPNGPNSQLPK----WERISPDDEHMKL-----ISIKPEPEM 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	163/569 (29%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	50/117 (43%)
cest-24	NP_504613.1	COesterase	97..608	CDD:278561	161/565 (28%)
cest-24	NP_504613.1	Aes	<183..>285	CDD:223730	40/104 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	222	1.000	Domainoid score	I1478
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	226	1.000	Inparanoid score	I2231
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm14771
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.970