Protein Alignment alpha-Est4 and cest-35.1

DIOPT Version :10

• Sequence 1: NP_524266.1
• Gene: alpha-Est4 / 40906
• FlyBaseID: FBgn0015572
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_504400.1
• Gene: cest-35.1 / 178912
• WormBaseID: WBGene00015067
• Length: 545
• Species: Caenorhabditis elegans
• Alignment Length: 589
• Identity: 155/589 - (26%)
• Similarity: 254/589 - (43%)
• Gaps: 125/589 - (21%)

  Fly     1 MSDDYNEDAPVVQTTHGKVRGILLKSLYDEQFYAFD---GIPYAVPPLGTLRFKEPHDLKPWHGI 62
            :..::|.:  |:..:.|.:||    ::|:......|   |||:|..|:|.||||:..:.:.|...
 Worm     8 LKPEHNTE--VLNASCGPIRG----NIYEHDDKIVDGYLGIPFAKAPIGELRFKKSVEAEKWTEP 66

  Fly    63 RDCSK-----PLSKCL------QVSTLTKEVEGSEDCLYLNI------SVKTLNGDPMPVMVYIH 110
            .||.|     |.|..|      |.|.:.:..|  ::||.||:      |.:..||  :||:||.:
 Worm    67 LDCYKYGPGCPQSGALGAMIVPQASAIREFAE--DNCLTLNVFAPKWKSAEFPNG--LPVIVYFY 127

  Fly   111 GGAFKGGDSSRRAWGPDYFMK-----ENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILA 170
            ||.|:.|.||   ...||.:.     ::|:.::..:|:|||||.:..| |:. .||.||.|..||
 Worm   128 GGGFEVGFSS---MFDDYSLTGTLPLKDVILVTPNYRIGPLGFFATGD-DVS-RGNWGLWDQALA 187

  Fly   171 LRWIRANAANFNGDPERITIFGHSSGSMTVQLLLASPQSEGLFHRAILLAG-----FSMELNRLP 230
            |:|::.:..:|.|||..:||.|.|:|..:|..|..||.:...||:.|.::|     |.:....:.
 Worm   188 LQWVQKHIKSFGGDPSNVTISGTSAGGASVDFLSLSPHANKYFHKFIPMSGAATCPFGIRSKDVE 252

  Fly   231 QMEYR-LAKHLGYEGDNVD-------SQVLEFLLKADPALIVSADFFTPLEKRQGHNMPFKPSIE 287
            .:.:| .|||.||.|::.:       ||..|..|||:.....::..|:           |.|:.:
 Worm   253 GLIFREFAKHHGYAGNDSESLLHWYQSQDAEIFLKAEGFKYPASGMFS-----------FVPNYD 306

  Fly   288 SYSTPNAVLLAEPIDLQRTTWSNRIPIILGANSGEGMSIFSFVKMNPSWLKEFQCNPERVL---- 348
            ....|      :|.|..|.. :.::..|:.....||:   .|.:..|.     |.:|:.||
 Worm   307 GDFFP------KPFDELRKE-APKLDAIVSVAEYEGL---GFEEFYPG-----QKSPQEVLTAAL 356

  Fly   349 -PWTLRNRCDPGQRRQLGQALIHHFCEAHGHELTVDHTNGLVELF-THGFVHAMDRLIQSRLTYG 411
             |..:|||.:..::..  :|.:.:..:..|.::    ...|||:| .:.|...:...::|...||
 Worm   357 GPEVVRNREEVVKKAV--EAYLENIEDKSGEKI----GKKLVEIFGDYYFSVGVFDTVRSLAKYG 415

  Fly   412 QAPTYLYRFDFDSPDFNFYRIRFMGKEQR---GVGHVDELGYIFKLPATFKLDKSRPEFTAIRRL 473
            . ..||..|::.:|:     ...|..|.|   ...|..::.||        |.....||:...|.
 Worm   416 N-NVYLSSFNYFNPE-----TPIMFGENRPFNAASHGCDIRYI--------LGDGIGEFSKEDRK 466

  Fly   474 V-----AMFVQFAATSDPNAPLTKSL-VDWKPVTRFGKRMVLNISEELKF-IPQPEMPKLKFFDR 531
            |     .....||...:||.   |.: :.|:      |..:.|.....|. .|:.||.. .|.|.
 Worm   467 VMDMMGTYLTNFAKYGNPNG---KGVSIPWE------KYSLDNPGRYFKIDYPKCEMAD-NFLDG 521

  Fly   532 LYEM 535
            .|::
 Worm   522 RYKI 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	alpha/beta hydrolases	8..529	CDD:473884	151/574 (26%)
cest-35.1	NP_504400.1	COesterase	16..523	CDD:395084	153/575 (27%)