DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est4 and cest-32

DIOPT Version :9

Sequence 1:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_504397.1	Gene:	cest-32 / 178909	WormBaseID:	WBGene00016862	Length:	545	Species:	Caenorhabditis elegans

Alignment Length:	588	Identity:	156/588 - (26%)
Similarity:	247/588 - (42%)	Gaps:	144/588 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VVQTTHGKVRGILLKSLYDEQFY-AFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLSKCLQ 74
            |:..:.|.|.|.:.:  :|::.. .:.|||:|..|:..||||:|.:.:.|....:|.|....|.|
Worm    16 VLNASCGPVIGNIYR--HDDKIVNGYLGIPFAKAPICELRFKKPVEAEKWTKPLNCHKYGPGCPQ 78

  Fly    75 VSTLTKEV------EGSED-CLYLNI------SVKTLNGDPMPVMVYIHGGAFKGGDSSRRAWGP 126
            ...:...:      |.:|| ||.|||      |.:..||  :|:|||.|||.|:.|.||   ...
Worm    79 SGHMISNLLPPGYREFAEDNCLNLNIFAPSWKSEEFPNG--LPIMVYFHGGGFEIGFSS---MFD 138

  Fly   127 DYFMK-----ENVVYISIGHRLGPLGFLSLNDPDLEVP-GNAGLKDVILALRWIRANAANFNGDP 185
            ||.:.     ::|:.::..:|:|||||::..|   ||. ||.||.|..|||:|::.:..:|.|:|
Worm   139 DYSLSGTLPLKDVIVVTANYRVGPLGFMTTGD---EVSRGNYGLWDQTLALKWVQEHIKSFGGNP 200

  Fly   186 ERITIFGHSSGSMTVQLLLASPQSEGLFHRAILLAG-----FSMELNRLPQMEYR-LAKHLGYEG 244
            ..:|:.|.|:|.::..||..||.|..||||.:.::|     ||:.........:| .|||.||||
Worm   201 NIVTVCGTSAGGVSAGLLALSPHSNKLFHRFMAMSGSAFCEFSIRTKEQEAEIFRNFAKHHGYEG 265

  Fly   245 DNVDSQVLEFLLKADP--ALIVSADFFTPLEKRQGHNMPFKPSIESYSTPNAVLLAEPID-LQRT 306
            ::.:| :||: .|:.|  ....:|.|    ||:....:.|.|:.:....|      :|.| |.|.
Worm   266 EDSES-LLEW-YKSQPLSKFQETATF----EKKASGFLTFIPNFDGDFFP------KPFDELSRE 318

  Fly   307 TWSNRIPIILGANSGEGMSIFSFVKMNPSWLKEFQCNPERVLPWTLRNRCDPGQRRQLGQALIHH 371
              :.::..:...:..||:          .:|..||         :.||..|. .:...|..::
Worm   319 --APKLDAMATVDEYEGL----------GFLTMFQ---------SRRNDMDI-IKSSFGSDVV-- 359

  Fly   372 FCEAHGHELTVDHTNGLVELFTHGFVHAMDRLIQSRL---------------------TYGQAPT 415
                   |..||....::|.:........|:.::.||                     .|| :..
Worm   360 -------ENAVDVQKRIMEFYMKNIDKNDDKAVEKRLIQLISDSWFNIGALETVKTSTKYG-SNA 416

  Fly   416 YLYRFDFDSPDFNFYRIRFMGKEQ--------RGVGHVDELGYIFKLPATFKLDKSRPEFTAI-- 470
            ||..||:    :|      ||...        :...|..||.|:.. ....|......||..|
Worm   417 YLGSFDY----YN------MGSNDPYATWFPFKAANHGSELKYMLG-EGMGKFSPIEEEFKVIDM 470

  Fly   471 -RRLVAMFVQFAATSDPNAP-LTKSLVDWKPVTRFGKRMVLNISEELKFIPQPEM------PKLK 527
             ..|.|.||::...:..|.| |.|.....||.:.|          ::.: |:.||      .:||
Worm   471 MGTLTANFVKYGNPNGINGPELWKKYTPEKPYSYF----------KIDY-PKSEMRDNFQDGRLK 524

  Fly   528 FFD 530
            .|:
Worm   525 LFE 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	155/585 (26%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	48/120 (40%)
cest-32	NP_504397.1	COesterase	15..516	CDD:278561	153/575 (27%)
cest-32	NP_504397.1	Aes	<104..>227	CDD:223730	48/130 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157258
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.740