Protein Alignment alpha-Est4 and cest-6

DIOPT Version :10

• Sequence 1: NP_524266.1
• Gene: alpha-Est4 / 40906
• FlyBaseID: FBgn0015572
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_501070.1
• Gene: cest-6 / 177459
• WormBaseID: WBGene00020688
• Length: 583
• Species: Caenorhabditis elegans
• Alignment Length: 554
• Identity: 124/554 - (22%)
• Similarity: 211/554 - (38%)
• Gaps: 125/554 - (22%)

  Fly     8 DAPVVQTTHGKVRGILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLSKC 72
            :|.|:.|:.|.:.|..:.|     :..|..||:|.||:|.|||::|...:.|.||.:.::....|
 Worm    22 EAGVITTSLGSINGNQIGS-----YQTFKKIPFAKPPIGKLRFQKPMAAEKWEGILNATEYGPAC 81

  Fly    73 LQVSTLTKEVEG--SEDCLYLNI--SVKTLNGDPMPVMVYIHGG--AFKGGDSSRRAWGPDYFMK 131
            :..|:.:|..:.  .||||::||  :...|:.....|:.|:|||  .:.........:..|.|..
 Worm    82 MSNSSTSKSPQKWIDEDCLHINIFTTDTCLSSKNCSVVFYVHGGELVYDSAVMFEDKYLFDTFSS 146

  Fly   132 ENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITIFGHSSG 196
            .:|:.:....|||......:.|.:: .|.|..|.|::|||.::::...||.|..:|:|.||||.|
 Worm   147 RDVILVIPAFRLGLFSHFVVEDQNV-APNNLALYDILLALEFVKSEIHNFGGSSDRVTAFGHSYG 210

  Fly   197 SMTVQLLLASPQSE---GLFHRAILLAGFSMELNRLPQMEYRLAK---HLGYEGDNV-------- 247
            ...|.::..|.:..   ..|.|.|.::    .:|....:|:.:.|   .:.|...:|
 Worm   211 GHVVSVMAFSTEINTDLSYFQRVICMS----SVNVWDSLEFEIEKTMRFIQYANCSVPQDLKSRM 271

  Fly   248 -----DSQVLEFLLKADPALIVSADFFTPLEKRQGHNMPFKPSIESYSTP--NAVLLAEPIDLQR 305
                 ||.::|.|...|...:                :..:.|:|....|  :.::|.||: :|.
 Worm   272 TSFEQDSYMMECLQDIDSMEL----------------LRIQRSLEDEGHPIYSGLVLREPL-IQN 319

  Fly   306 TTWSN------RIPIILGANSGEGMSIFSFVKMNPSWLKEFQC--NPERVLPWTLRNRCDPGQR- 361
            ....:      .||.:.|....|              |.:|..  |....|.:.....||...|
 Worm   320 VLVQDFYEKPKNIPTLTGCTYKE--------------LDKFHAYHNIVETLGYENYKECDDKYRD 370

  Fly   362 -RQLGQALIHHFCEAHGHELTVDHTNGLVELFTHGFVHAMDRL-IQSRLTYGQAPTYLYRFDFDS 424
             |:.|:      .:.:.|   .|.|.|::         |..:| :..:|..| .|||.|.:.:
 Worm   371 DRKYGR------FDLNKH---ADETFGIL---------AQTKLKVDKQLDKG-IPTYFYEYSY-- 414

  Fly   425 PDFNFYRIRFMGKEQRGVGHVDELGYIFKLPATFKLDKSRPEFTAIRRLVAMFVQFAATSDPNAP 489
                          .:...|.|:|.||..:.|   .:|...|....:....||:.|....:|...
 Worm   415 --------------PKHPSHTDDLSYIMGVHA---FEKDENEIHLAKSYQEMFMNFVKFGEPGGG 462

  Fly   490 LTKSLVD--------WKPVTRFGKRMVLNISEEL 515
            ...|..:        |...|.....|..|..:|:
 Worm   463 FEMSTFENSSYFNFYWNETTGEKSSMKTNFEKEI 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	alpha/beta hydrolases	8..529	CDD:473884	124/554 (22%)
cest-6	NP_501070.1	alpha/beta hydrolases	25..500	CDD:473884	123/551 (22%)