DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est4 and cest-4

DIOPT Version :9

Sequence 1:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_501043.1	Gene:	cest-4 / 177445	WormBaseID:	WBGene00015930	Length:	592	Species:	Caenorhabditis elegans

Alignment Length:	506	Identity:	118/506 - (23%)
Similarity:	191/506 - (37%)	Gaps:	101/506 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VVQTTHGKVRGILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLSKCLQV 75
            :|.|:.|::.|..:.|     |:.|..||.|.||:|.|||::|...:.|.|:|:.......|:..
Worm    28 IVSTSLGQIDGDQIGS-----FHLFKHIPLAKPPIGKLRFQKPEPPEKWTGVRNAKAYGPACISN 87

  Fly    76 STLTKEVEG--SEDCLYLNI--SVKTLNGDPMPVMVYIHGGAFKGGDSSRRAWGPDY----FMKE 132
            |:::...:.  .||||::||  |.|.|......|:.|.|||...  ..|...:...|    |:.:
Worm    88 SSVSTSPQKWIDEDCLHINIFTSDKCLKSKDCAVVTYFHGGGLM--YDSAVMFNDTYLLGTFVNQ 150

  Fly   133 NVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITIFGHSSGS 197
            :|:......|||......:.|..: .|.|..|.|::|.:.:::....||.|:.::.||.|||.|.
Worm   151 DVIIAIPAFRLGIFSHFVVEDQSI-APTNLALYDILLGVEFVKNEIHNFGGNNQKNTIMGHSYGG 214

  Fly   198 MTVQLLLASPQSE---GLFHRAILL-AGFSMELNRLP-QMEYRLAKHLGYEGDNV---------- 247
            ..|.:|..|.:..   .||.::|.: :|...|...:. |...|.|||.|....::
Worm   215 SIVNILTFSSKINHDLSLFQQSICMSSGHDFETLEIQIQKTNRFAKHAGCTVPSIIEKKMTTRQS 279

  Fly   248 DSQVLEFLLKADPALIVSADFFTPLEKRQGHNMPFKPSIESYSTPNAVLLAEPIDLQRTTWSNRI 312
            |...::.|...|...::.....  ||.            |.|.|...::..||:       ...|
Worm   280 DLYRMKCLQNKDALELLRVQRL--LED------------EGYPTYGYLVQREPL-------IQEI 323

  Fly   313 PIILGANSGEGMSIFSFVKMNPSWLKEFQCNPERV--LPWTLRNRCDPGQR-RQLGQALIHHFCE 374
            |                       .:||..:|:::  |....|...|.... :.:||||.....|
Worm   324 P-----------------------YQEFMKSPKKIPMLTGCTRYEMDHSPAPKPIGQALGFENPE 365

  Fly   375 AHGHELTVDHTNGLVELFTHG----FVHAMDRLIQSRLTYGQAPTYLYRFDFDSPDFNFYRIRFM 435
            ....:...|..:.:.|...|.    .:....|:..:.|.....|.|||.:.:.
Worm   366 EVYMKFRKDWDDEVYEFGNHSDETQAIMVQVRVRVNNLLSKNVPAYLYEYTYP------------ 418

  Fly   436 GKEQRGVGHVDELGYIFKLPATFKLDKSRPEFTAIRRLVAMFVQFAATSDP 486
             |..|   |.|:|   |.|....:.:|...|....:....:|:.||...||
Worm   419 -KHAR---HTDDL---FYLMGVHRFEKDENEIELGKVYETIFMNFAKFGDP 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	118/506 (23%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	33/121 (27%)
cest-4	NP_501043.1	Abhydrolase	28..503	CDD:389770	118/506 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810