DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est4 and cest-5.1

DIOPT Version :9

Sequence 1:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_501022.3	Gene:	cest-5.1 / 177429	WormBaseID:	WBGene00015279	Length:	580	Species:	Caenorhabditis elegans

Alignment Length:	602	Identity:	141/602 - (23%)
Similarity:	245/602 - (40%)	Gaps:	145/602 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DAPVVQTTHGKVRGILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLSKC 72
            |:.::.|:.|.:.|..:     ..::.|..||:|.||:|.|||::|.....|.|||...:....|
Worm    17 DSLIIHTSFGHLEGAEI-----GDYHLFKKIPFAKPPVGNLRFQKPEAAGKWDGIRSAIEYGPAC 76

  Fly    73 LQVSTLTKEVEG--SEDCLYLNI--SVKTLNGDPMPVMVYIHGG------AFKGGDSSRRAWGPD 127
            :..|:.||..:.  .||||::||  |.|.|......:.||||||      |....|:...    |
Worm    77 MSNSSKTKSPQKWVDEDCLHVNIFTSKKCLKSRNCAIAVYIHGGGLTYDSAVMFNDTVLL----D 137

  Fly   128 YFMKENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITIFG 192
            .|:|.:|:.:..|.|||.....::::.:: .|.|..|.|:.|||.::::...:|.|:.::||:||
Worm   138 TFVKRDVILVIPGFRLGIFSHFTVHNQNV-APNNLALYDITLALEFVKSEIHSFGGNSQKITLFG 201

  Fly   193 HSSGSMTVQLLLASPQSE---GLFHRAILLAG--FSMELNRLPQMEYRLAKH------LGYEGDN 246
            ||.|.....::..|.:..   .||.:||:::|  :..||....:...|..::      |..|...
Worm   202 HSYGGGLASMMTFSSEINRDLSLFQQAIVMSGGFYFEELKDHIEGTKRFVEYANCSVPLKLERKM 266

  Fly   247 VDSQVLEFLLKADPALIVSADFFTPLEKRQGHN-MPFKPSIESYSTPN--AVLLAEPI--DLQR- 305
            ..||...:::|.             |:|..|.. :..:..:|....|:  .|:|.||:  |:::
Worm   267 ERSQQEMYMMKC-------------LQKLSGMELLRIQRLLEDKGYPDFGGVILREPLFPDVKKF 318

  Fly   306 --TTWSNRIPIILGANSGEGMSIFSFVKMNPSWLK--EFQCNPERVLPWTLRNRCDPGQRRQLGQ 366
              ......||::.|..:.|    |....:...:.|  ||: ||:         .||...|..:..
Worm   319 ELLKSPKNIPMLTGCTNLE----FDHESIKVPFGKYLEFE-NPD---------ECDEKYRNDVES 369

  Fly   367 ALIHHFCEAHGHELTVDHTNGLV---ELFTHGFVHAMDRLIQSRLTYGQAPTYLYRFDFDSPDFN 428
            .:     |..|:.  .|.|.|::   :|       .::.|:::.:|     .|||.:.:.
Worm   370 GV-----ENRGNH--TDKTQGIILPLKL-------QINNLLENNVT-----AYLYEYTYP----- 410

  Fly   429 FYRIRFMGKEQRGVGHVDELGYIFKLPATFKLDKSRPEFTAIRRLVAMFVQFAATSDPNAPLTKS 493
                    |..|   |.|:|.||..:.| |:.|::......:.:  .|.:.|....:|.....||
Worm   411 --------KHGR---HTDDLSYIMGVHA-FEKDENEVHLEQVYK--DMVINFIKLGEPGMGFEKS 461

  Fly   494 L--------VDW---------------KPVTRFGKRMVLNISEE------------LKFIPQPEM 523
            .        :.|               |.||.:..:.::...::            ||.:|..|.
Worm   462 EQNESTYFDIYWNETTGERPRMRKYFEKEVTDYWLKEMIEFDQKVTETKKKLKQISLKTVPFIEK 526

  Fly   524 PKLKFFDRLYEMAGVPL 540
            | |:..|....:.||.|
Worm   527 P-LEQNDEAGTLIGVSL 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	137/589 (23%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	37/123 (30%)
cest-5.1	NP_501022.3	Abhydrolase	19..495	CDD:389770	130/550 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156914
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740