Protein Alignment alpha-Est4 and cest-25

DIOPT Version :9

• Sequence 1: NP_524266.1
• Gene: alpha-Est4 / 40906
• FlyBaseID: FBgn0015572
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_497609.1
• Gene: cest-25 / 175390
• WormBaseID: WBGene00022178
• Length: 550
• Species: Caenorhabditis elegans
• Alignment Length: 604
• Identity: 152/604 - (25%)
• Similarity: 236/604 - (39%)
• Gaps: 160/604 - (26%)

  Fly    12 VQTTHGKVRGILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLSKCLQVS 76
            |.|::|.:.|..|....::|..||.|||||.||:|.|||..|...:.|..:|:.....::.:|..
 Worm    19 VLTSYGPIEGRRLIHEGEKQVDAFQGIPYAAPPIGNLRFALPQPHEKWTEVRETKSFGARGIQKD 83

  Fly    77 TL--TKEVEGSEDCLYLNISVKT---LNGDPMPVMVYIHGGAF------KGGDSSRRAWGPDYFM 130
            .:  .|....|||.|.|||....   .|....||::|||||.|      |.||.|.    ..:.:
 Worm    84 HVLSPKTSPQSEDNLTLNIFTPVWTPKNETGFPVILYIHGGGFVSDSAHKYGDMSI----CQHLV 144

  Fly   131 KENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITIFGHSS 195
            .::||.::|.:|||.|||.:..|.  .:|.|..|.|::.||:|::.|...|||||..||:.|.|:
 Worm   145 TKDVVVVTIQYRLGFLGFWTTGDS--SIPDNVALHDMVFALKWVKENIGLFNGDPNNITLMGQSA 207

  Fly   196 GSMTVQLLLASPQSEGLFHRAILLAG---------------------------------FSMELN 227
            |..:|..|..||.|..||.:.|.:.|                                 :..:|.
 Worm   208 GGASVDFLSISPVSRDLFQKVIPMGGNASCSWAIHPRPLNACRNRAQEIGVFDGMNTLDWVEKLR 272

  Fly   228 RLPQMEYRLAKHLGYEGDNVDSQVLEFLLKADPALIVSADF---FTP---LEKRQGHNMPFKPSI 286
            .||..::..|.::    :.||:       |.||.|::...:   |.|   :|.|:  ..|.||.
 Worm   273 ELPADKFASALNM----EAVDT-------KTDPELLIGPKYDNLFIPRPVMELRK--EAPMKPR- 323

  Fly   287 ESYSTPNAVLLAEPIDLQRTTWSNRIPIILGANSGEGMSIFSFVKMNPSW-LKEFQCN-----PE 345
                                        :||....||: :|:|..:|... |...|.:     .|
 Worm   324 ----------------------------LLGCAKSEGL-VFAFFGLNTKHPLHAVQQDVSAILSE 359

  Fly   346 RVLPWTLRNRCDPGQRRQLGQALIHHFCEAHGHELTVDHT-----NGLVELFTHGFVHA--MDRL 403
            ::.|...|:.    |.:.|.:.:          |:..||:     ..:|:|....|::.  ...:
 Worm   360 KLFPLKARDY----QEKALEKLI----------EIGTDHSKEEWQRAMVDLKGDSFLNVGIQQNV 410

  Fly   404 IQSRLTYGQAPTYLYRFDFDSPDFNFYRIRFMGKEQRGVGHVDELGYIFKLPATFKLDKSRPEFT 468
            :....|....|.|:|.||:.:|  ..|.|.......:...|..::.|:.........|.:..::.
 Worm   411 LDVLETQPSTPIYMYSFDYCNP--KAYGIMGFKLPFKDATHCTDISYVVGNHIVNSFDFNEEDYK 473

  Fly   469 AIRRLVAMFVQFAATSDPN------APLTKSLVDWKPVTRFGKRMVLNISEELKFIPQPEM---- 523
            .|.....::..||...:||      |.|.:.   |:|.|         |..     ||..|
 Worm   474 MIEITTRLWTNFAKYGNPNGEGDDVAHLEEK---WEPAT---------IES-----PQTHMALTL 521

  Fly   524 -PKLKFFDRLYEMAGVPLF 541
             |||   ..:|:. |.|||
 Worm   522 QPKL---HHVYKQ-GRPLF 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	147/590 (25%)
		Aes	<104..>219	CDD:223730	48/120 (40%)
cest-25	NP_497609.1	COesterase	18..536	CDD:365897	150/602 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28578
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm14771
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.820