DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est4 and Ces2c

DIOPT Version :9

Sequence 1:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_598270.2	Gene:	Ces2c / 171118	RGDID:	621510	Length:	561	Species:	Rattus norvegicus

Alignment Length:	606	Identity:	170/606 - (28%)
Similarity:	256/606 - (42%)	Gaps:	150/606 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YNEDAP---VVQTTH-GKVRGILLKSLYDEQ--FYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIR 63
            :.:|:|   .::||| |:||| .|..:.|.:  .:.|.|||:|..|:|.|||..|.|.:||.|:|
  Rat    25 WGQDSPESSSIRTTHTGQVRG-KLDHVRDTKAGVHTFLGIPFAKAPVGPLRFAPPEDPEPWSGVR 88

  Fly    64 DCSKPLSKCLQ------------VSTLTKEVEGSEDCLYLNI--SVKTLNGDPMPVMVYIHGGAF 114
            |.:...:.|||            :..:...:..|||||||||  ......|..:||||.|||||.
  Rat    89 DGTSHPAMCLQNIDMLDEVGLTDMKMILSSIPMSEDCLYLNIYTPAHAHEGSNLPVMVCIHGGAL 153

  Fly   115 KGG-----DSSRRAWGPDYFMKENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWI 174
            ..|     |.|..|      :.|::|.::|.:|||.|||.|..|.  ...||.|..|.:.||||:
  Rat   154 VIGMASMCDGSLLA------VNEDLVVVAIQYRLGVLGFFSTGDE--HARGNWGYLDQVAALRWV 210

  Fly   175 RANAANFNGDPERITIFGHSSGSMTVQLLLASPQSEGLFHRAILLAGFSMELNRLPQM------- 232
            :.|.|:|.|:|.|:||||.|:|..:|...:.||.|:||||.||:.:|.::    ||.:
  Rat   211 QQNIAHFGGNPNRVTIFGVSAGGTSVSSHVISPMSQGLFHGAIMESGVAL----LPDLISETSET 271

  Fly   233 -EYRLAKHLGYEGDNVDSQVLEFLLKADPA---LIVSADFFTPLEKRQGHNMPFK--PSIESYST 291
             ...:||..|.|.  .||:.|...|:|...   |::              |..||  |::    .
  Rat   272 VSTTVAKLSGCEA--TDSETLVRCLRAKSGAEILVI--------------NKVFKMIPAV----V 316

  Fly   292 PNAVLLAEPIDLQRTTWSNRIPIILGANSGEGMSIFSFVKMNPSWLKEF-QCNPERVLPWT---- 351
            ....|...|.:|..:...:.:|.|:|.|:.|.......|......:||. :.|.:.||..|
  Rat   317 DGEFLPRHPKELLASEDFHPVPSIIGVNTDEYCCTIPMVMGTAQIIKELSRENLQAVLKDTAAQM 381

  Fly   352 --------------LRNRCDPGQRRQLGQALIHHFCEAHGHELTVDHTNGLVELFTHGFVHAMDR 402
                          :.|..||       |.|...:.|..|                 .|:..:..
  Rat   382 MLPPECGDLLMEEYMGNTDDP-------QTLQIQYAEMMG-----------------DFLFVIPA 422

  Fly   403 LIQSRLTYGQAPTYLYRFDFDSPDFNFYRIRFMGKEQRGVGHVDELGYIFKLPATF----KLDKS 463
            |..:......||.|.|.|. .:|.: |..:|   .......|.||:.::|   .:|    |:|.:
  Rat   423 LQVAHFQRSHAPVYFYEFQ-HAPSY-FKNVR---PPHVKADHADEVPFVF---GSFFWGIKVDFT 479

  Fly   464 RPEFTAIRRLVAMFVQFAATSDPNAPLTKSLVDWKPVTRFGKRMVLNISEE-LKFIPQPEMP--- 524
            ..|....||::..:..||...:||   ::.|..|.         ||:..|: |:...||.:.
  Rat   480 EEEKLLSRRMMKYWANFARHGNPN---SEGLPYWP---------VLDHDEQYLQLDTQPAVDRAL 532

  Fly   525 ---KLKFF-----DRLYEMAG 537
               :|:|:     .::.|:.|
  Rat   533 KARRLQFWTKTLPQKIQELNG 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	167/589 (28%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	54/119 (45%)
Ces2c	NP_598270.2	COesterase	32..540	CDD:395084	165/584 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820