DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est4 and Ces3b

DIOPT Version :9

Sequence 1:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_653094.2	Gene:	Ces3b / 13909	MGIID:	3644960	Length:	571	Species:	Mus musculus

Alignment Length:	555	Identity:	158/555 - (28%)
Similarity:	233/555 - (41%)	Gaps:	113/555 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PVVQTTHGKVRG--ILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLSKC 72
            |.|.|..|:|||  :.:|.. |.....|.|||:|..|:|.|||..|...:||.|:||.|.....|
Mouse    37 PEVDTPLGRVRGRQVGVKDT-DRMVNVFLGIPFAQAPVGPLRFSAPLPPQPWEGVRDASINPPMC 100

  Fly    73 LQ-VSTLTKEVEG----------SEDCLYLNISVKT--LNGDPMPVMVYIHGGAFKGGDSSRR-- 122
            || |..:.....|          |||||.|||...|  ..||..||||:||||:...|.|:.:
Mouse   101 LQDVEKMINSRFGLNEKIKIFPISEDCLTLNIYSPTEITAGDKRPVMVWIHGGSLLVGSSTSQDG 165

  Fly   123 ----AWGPDYFMKENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNG 183
                |:|       :||.:::.:|||..||||..|.  .:|||.|..||:.||||::.|.|.|.|
Mouse   166 SALAAYG-------DVVVVTVQYRLGIFGFLSTGDK--HMPGNRGFLDVVAALRWVQGNIAPFGG 221

  Fly   184 DPERITIFGHSSGSMTVQLLLASPQSEGLFHRAILLAG----FSME-LNRLPQMEYRLAKHLGYE 243
            ||..:||||:|:|.|.|..|..||.|.|||||||..:|    ..|| :...|            |
Mouse   222 DPNCVTIFGNSAGGMIVSSLFLSPISAGLFHRAISQSGIVTTIMMEDMKPWP------------E 274

  Fly   244 GDNVDSQVLEFLLKADPALIVSADFFTPLEKRQGHNMPFKPSIE-SYSTPNAVLLAEPIDLQRTT 307
            ..|..:.|.  ...|.||.:|..     |.:::|.::..:.::. ||...::.....|..|....
Mouse   275 AQNFANSVA--CGSASPAELVQC-----LLQKEGKDLIKQKNVNISYIVNDSFFPQRPEKLLADQ 332

  Fly   308 WSNRIPIILGANSG----------------EGMSIFSFVKMNPSWLKEFQCNPERVLPWTLRNRC 356
            ....:|.:||..:.                |.:|....::::..:|...:..|| ::|..:....
Mouse   333 QFPTVPYLLGVTNHEFGWLLLKSLNILDKLEHLSREDLLEISRPFLAIMEVPPE-IMPTVIDEYL 396

  Fly   357 DPGQRRQLGQALIHHFCEAHGH-ELTVDHTNGLVELFTHGFVHAMDRLIQSRLTYGQAPTYLYRF 420
            |.|..:   .|..:.|.|..|. ...:...|                 ....|.....|.:||.|
Mouse   397 DNGSDQ---SATRYAFQELLGDISFIIPTLN-----------------FSKYLRDAGCPVFLYEF 441

  Fly   421 DFDSPDFNFYRIRFMGKEQRGVGHVDELGYIFKLPATFKLDKSR----PEFTAIRR-----LVAM 476
            ......|..::..::..:     |..|..::|..|  |..|:|.    ||.|...:     ::|.
Mouse   442 QHTPSSFAKFKPAWVKAD-----HASENSFVFGGP--FLTDESSLLAFPEATEEEKQLSLTMMAQ 499

  Fly   477 FVQFAATSDPNAPLTKSLVDWKPVTRFGKRMVLNI 511
            :.|||.|.:||.   |.|..|..:.:..:.:.:.:
Mouse   500 WSQFARTGNPNG---KGLPPWPQLNQLEQYLEIGL 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	158/555 (28%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	57/120 (48%)
Ces3b	NP_653094.2	COesterase	36..547	CDD:278561	158/555 (28%)
		Aes	75..>245	CDD:223730	73/178 (41%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832494
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740