Protein Alignment alpha-Est4 and Ces1e

DIOPT Version :10

• Sequence 1: NP_524266.1
• Gene: alpha-Est4 / 40906
• FlyBaseID: FBgn0015572
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_598421.1
• Gene: Ces1e / 13897
• MGIID: 95432
• Length: 562
• Species: Mus musculus
• Alignment Length: 546
• Identity: 159/546 - (29%)
• Similarity: 235/546 - (43%)
• Gaps: 112/546 - (20%)

  Fly    10 PVVQTTHGKVRG--ILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLSKC 72
            |:|.|..|||.|  |.|:. :.:....|.|:|:|.||||:|||..|...:||..:::.:.....|
Mouse    25 PMVDTVQGKVLGKYISLEG-FTQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSSVKNATSYPPMC 88

  Fly    73 LQ----------VSTLTKE---VEGSEDCLYLNI--SVKTLNGDPMPVMVYIHGGAFKGGDSSRR 122
            .|          :.|..||   ::.|||||||||  .......|.:||||:||||....|.:|..
Mouse    89 FQDPVTGQIVNDLLTNRKEKIPLQFSEDCLYLNIYTPADLTKSDRLPVMVWIHGGGLVLGGASTY 153

  Fly   123 AWGPDYFMKENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPER 187
            . |......||||.:.|.:|||..||.|..|....  ||.|..|.:.||.|::.|.|.|.|||..
Mouse   154 D-GLVLSTHENVVVVVIQYRLGIWGFFSTGDEHSR--GNWGHLDQVAALHWVQDNIAKFGGDPGS 215

  Fly   188 ITIFGHSSGSMTVQLLLASPQSEGLFHRAILLAGFSM-----ELNRLPQMEYRLAKHLGYEG--- 244
            :||||.|:|..:|.:|:.||.::.||.|||..:|.::     :.|..|..| ::|...|.:.
Mouse   216 VTIFGESAGGESVSVLVLSPLAKNLFQRAISESGVALTAGLVKKNTRPLAE-KIAVISGCKNTTS 279

  Fly   245 --------DNVDSQVLEFLLKADPALIVSADFFTPLEKRQGHNMPFKPSIESYSTPNAVLLAE-P 300
                    ...:.::|...||.:   :...|...  :.||.|  ||.|::     .:.|||.: |
Mouse   280 AAMVHCLRQKTEEELLGTTLKLN---LFKLDLHG--DSRQSH--PFVPTV-----LDGVLLPKMP 332

  Fly   301 IDLQRTTWSNRIPIILGANSGE-GMSIFSFVKMNPSWLK-------------EFQCN-PERVLPW 350
            .::......|.:|.|:|.|..| |..:.:.:...||.:|             .|..| ||..:..
Mouse   333 EEILAEKNFNTVPYIVGINKQEFGWILPTMMNYPPSDVKLDQMTAMSLLKKSSFLLNLPEDAIAV 397

  Fly   351 T----LRNRCDPGQRRQLGQALIHHFCEAHGHELTVDHTNGLVELFTHGFVHAMDRLIQSRLTYG 411
            .    ||::...|:.:                       :.|:||. ...|..:..:|.||   |
Mouse   398 AIEKYLRDKDYTGRNK-----------------------DQLLELI-GDVVFGVPSVIVSR---G 435

  Fly   412 Q----APTYLYRFDFDSPDFNFYRIRFMGKEQRGVG-HVDELGYIFKLPATFKLDKSRPEFTAIR 471
            .    ||||:|.|.: ||.|:...     |....|| |.||:..:|..| ..:...|..|....:
Mouse   436 HRDAGAPTYMYEFQY-SPSFSSEM-----KPDTVVGDHGDEIYSVFGAP-ILRGGTSEEEINLSK 493

  Fly   472 RLVAMFVQFAATSDPNAPLTKSLVDW 497
            .::..:..||...:||.   :.|..|
Mouse   494 MMMKFWANFARNGNPNG---QGLPHW 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	alpha/beta hydrolases	8..529	CDD:473884	159/546 (29%)
Ces1e	NP_598421.1	COesterase	23..546	CDD:395084	159/546 (29%)
		Prevents secretion from ER. /evidence=ECO:0000255	559..562